ID A0A151NF92_ALLMI Unreviewed; 814 AA.
AC A0A151NF92;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Phosphatidylinositol-glycan-specific phospholipase D {ECO:0000256|ARBA:ARBA00015988};
DE EC=3.1.4.50 {ECO:0000256|ARBA:ARBA00012284};
DE AltName: Full=Glycosyl-phosphatidylinositol-specific phospholipase D {ECO:0000256|ARBA:ARBA00029753};
GN Name=GPLD1 {ECO:0000313|EMBL:KYO35444.1};
GN ORFNames=Y1Q_0008017 {ECO:0000313|EMBL:KYO35444.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO35444.1};
RN [1] {ECO:0000313|EMBL:KYO35444.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO35444.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-
CC myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a
CC 1,2-diacyl-sn-glycero-3-phosphate + H(+); Xref=Rhea:RHEA:10832,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57997,
CC ChEBI:CHEBI:58608, ChEBI:CHEBI:58700; EC=3.1.4.50;
CC Evidence={ECO:0000256|ARBA:ARBA00034002};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the GPLD1 family.
CC {ECO:0000256|ARBA:ARBA00008652}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO35444.1}.
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DR EMBL; AKHW03003201; KYO35444.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NF92; -.
DR STRING; 8496.A0A151NF92; -.
DR eggNOG; KOG3637; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004621; F:glycosylphosphatidylinositol phospholipase D activity; IEA:UniProtKB-EC.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 3.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR001028; Gprt_PLipase_D.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR029002; PLPC/GPLD1.
DR PANTHER; PTHR23221; GLYCOSYLPHOSPHATIDYLINOSITOL PHOSPHOLIPASE D; 1.
DR PANTHER; PTHR23221:SF7; PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D; 1.
DR Pfam; PF01839; FG-GAP; 4.
DR Pfam; PF00882; Zn_dep_PLPC; 1.
DR PRINTS; PR00718; PHPHLIPASED.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR PROSITE; PS51470; FG_GAP; 4.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 7..165
FT /note="Phospholipase C/D"
FT /evidence="ECO:0000259|Pfam:PF00882"
FT REPEAT 345..406
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 414..475
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 478..537
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 681..747
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 814 AA; 90610 MW; C42A7A9BE79067F6 CRC64;
MLCGISTHIE IAHRALEFFD KHERNINYRQ LLLNHQDAFQ AGSVYPDAFY PVICKNGIFH
RVSEDTHWTP FLNTSIHYIR RHYPHPWEEA TEKLVAFLFG IASHMVADVN WHSLGIDQGF
LQTMGAIDFH GSYSEAHQVG DFGGDVLSQF ELDFSYLEAD WYIPVKDLIA IYQEFYGEKV
VTEGTIIDCT YLQFLELYGE KLAVAKLFPT YAGKSPFLVE KFHEYFLGGM DDMAFWSNNI
FQLTGHMLEA GTSGCFMPEN PLFIDCNRRH RQSYRIKQSK NEHQENMTSS LAKQVDKNIN
YTERGVYFRQ TWATNSLHFI NGAFATNVQK VLAVTHQHAS NHVTKPTASY FLKSPYARLG
WAMTSADLNQ DGYEDLVVGA PGYSRLGWVQ IGRVYIIYSK QSGLPPVNMN LNKKADQVLE
GHQPSGRFGS AVSVLDFNED GVPDLAVGAP SVGSQLLTYK GAVYIYFGTE GKGFSSWPNI
TITCQYTYCN LGWSLLATDI DGDGRSDLVA GSPYAPGGGK QRGFVVAFYS YFNRSNQGLL
SVEDADWMVK GEKNYAWFGY SLDRHQMENM SLLLIGSPTW KHCISLDCHV SSDSRENVGK
VYAYNPPSAH SWFAVTGDGE MGKLGLSLAS GFVSVAGIPR RVLLVGAPTS DSTSRIVFIH
SVLHQAGTVL MYDLTDNTKP SLLSTFSGDR KFSRFGGAVH LSDLDGDGLD EIVVTSPLRT
TDITSGIFGG EAGRVYIYNG NQTTLGDVTD HCKSWTSPCP EDWAQYVLIS PEERSRFGSS
VITVKSEAKS EVVVAAERSS VKARLGGRLF LYAL
//
