ID A0A151NFC5_ALLMI Unreviewed; 699 AA.
AC A0A151NFC5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Receptor-interacting serine/threonine-protein kinase 1 {ECO:0000313|EMBL:KYO35487.1};
GN Name=RIPK1 {ECO:0000313|EMBL:KYO35487.1};
GN ORFNames=Y1Q_0008053 {ECO:0000313|EMBL:KYO35487.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO35487.1};
RN [1] {ECO:0000313|EMBL:KYO35487.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO35487.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO35487.1}.
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DR EMBL; AKHW03003201; KYO35487.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NFC5; -.
DR STRING; 8496.A0A151NFC5; -.
DR eggNOG; KOG0192; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:UniProt.
DR GO; GO:0031349; P:positive regulation of defense response; IEA:UniProt.
DR GO; GO:0032103; P:positive regulation of response to external stimulus; IEA:UniProt.
DR GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR GO; GO:0006950; P:response to stress; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR025735; RHIM_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR23257:SF983; RECEPTOR INTERACTING SERINE_THREONINE KINASE 1; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF12721; RHIM; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Kinase {ECO:0000313|EMBL:KYO35487.1};
KW Receptor {ECO:0000313|EMBL:KYO35487.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transferase {ECO:0000313|EMBL:KYO35487.1};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 6..281
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 611..697
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 314..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 699 AA; 79436 MW; 92757958DFAABF80 CRC64;
MNSKDLLKKE QLDAGGFGIV SLCLHKTQGL VVLKTVYTGP QRTEFNASLL EEGKIMRKLK
HDRVVKLLGV ILEDGNYSLV MEYVHRGSLM HMLKTSTIPM PLKGRFILEI IEGMVYLSEQ
GLVHKDLKPE NILVDNDFHI KIADLGVACF KNWSRLTKEE TNRQRKLKSA SKNASQSNAG
TLFYMAPEHL ISLNIKPVEK SDVYSFGIVL WAIFANKEPY EHGINEEQIY YGITNGSRPD
TDEIKGSCPE TIISLMKQCW EQKPETRPTF KEISSVYKPF YYNCLEQDVE DEVRKIKIEY
PAPPEKIQRM QSLQIDAVSE SPSTTSPDQP TSLHSSQGLS AGNVNEAMFA ACPDHHPVES
CETSLEPFMN LERKLQDEYN YHKYGSRMDK SESQPIMYTH EMKEEERRRR VSHDPFAKPS
FAPQMKESHV KTENTGPKAS PFNKTTNYSH FRQQPPAGMP TQEYLPYTPN VTYGARAADF
TAGSTEDLYG SGSANTFSLN KPPVPESGLD HQPQTSPAWF PKSLQTEPGK IQPSQFKRKT
FEYFSAVPVV QPKSIEGDIY IHNSAGIQIG RNNHMKIEDQ NLYVKSCSVS AQNSSADYER
TGIFDSTTIL SEEHLNLVRE NLAKQWKDCA RRLGFTNPDI EVIDHDYERD GLKEKVYQML
QNWLMREGSQ GTTVGKLARA LYGCRRLDLL NALIKMNQR
//
