ID A0A151NHC3_ALLMI Unreviewed; 279 AA.
AC A0A151NHC3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Sesquipedalian {ECO:0000256|RuleBase:RU369082};
DE Short=Ses {ECO:0000256|RuleBase:RU369082};
DE AltName: Full=PH domain-containing endocytic trafficking adaptor {ECO:0000256|RuleBase:RU369082};
GN Name=FAM109B {ECO:0000313|EMBL:KYO36221.1};
GN ORFNames=Y1Q_0024011 {ECO:0000313|EMBL:KYO36221.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO36221.1};
RN [1] {ECO:0000313|EMBL:KYO36221.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO36221.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- FUNCTION: Plays a role in endocytic trafficking. Required for receptor
CC recycling from endosomes, both to the trans-Golgi network and the
CC plasma membrane. {ECO:0000256|RuleBase:RU369082}.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|RuleBase:RU369082}.
CC Recycling endosome {ECO:0000256|RuleBase:RU369082}. Golgi apparatus,
CC trans-Golgi network {ECO:0000256|RuleBase:RU369082}. Cytoplasmic
CC vesicle, clathrin-coated vesicle {ECO:0000256|RuleBase:RU369082}.
CC -!- SIMILARITY: Belongs to the sesquipedalian family.
CC {ECO:0000256|RuleBase:RU369082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO36221.1}.
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DR EMBL; AKHW03002956; KYO36221.1; -; Genomic_DNA.
DR RefSeq; XP_019345076.1; XM_019489531.1.
DR RefSeq; XP_019345077.1; XM_019489532.1.
DR RefSeq; XP_019345078.1; XM_019489533.1.
DR AlphaFoldDB; A0A151NHC3; -.
DR STRING; 8496.A0A151NHC3; -.
DR GeneID; 102560813; -.
DR CTD; 150368; -.
DR eggNOG; ENOG502QQ94; Eukaryota.
DR OrthoDB; 5483476at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:UniProtKB-UniRule.
DR GO; GO:0007032; P:endosome organization; IEA:UniProtKB-UniRule.
DR GO; GO:0001881; P:receptor recycling; IEA:UniProtKB-UniRule.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:UniProtKB-UniRule.
DR CDD; cd13288; PH_Ses; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045188; Boi1/Boi2-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22902; SESQUIPEDALIAN; 1.
DR PANTHER; PTHR22902:SF15; SESQUIPEDALIAN-2; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|RuleBase:RU369082};
KW Endosome {ECO:0000256|RuleBase:RU369082};
KW Golgi apparatus {ECO:0000256|RuleBase:RU369082};
KW Phosphoprotein {ECO:0000256|RuleBase:RU369082};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 29..132
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 157..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 279 AA; 31580 MW; 9C7F70B04837E744 CRC64;
MLEMYREKLA KKMKLNERSV VHYATCDSPA DHAGFLRKRV ERHHHHHHHT TSYHRRWFIL
KGNLLFYFED RDSREPLGLV VLEGCTVELC ESAEEFAFAI HFEDAGAKAY VLVADCHVAM
EAWVKALSRA SFDYMRLVVK ELERQLEDAR KSLAACHKSP RKLSSGRKRH LSNPALPPVQ
EKPPILENGY STWGSSCTPA GASCCDQDGG FSKPPPLPPR RRSAGGSLYI APTSGLSLTL
QESPVSPETA CFSKLHHWYG QEIAEVRREW LESKKSGEL
//
