ID A0A151NI15_ALLMI Unreviewed; 395 AA.
AC A0A151NI15;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Solute carrier family 41 member {ECO:0000256|RuleBase:RU369007};
GN Name=SLC41A2 {ECO:0000313|EMBL:KYO36438.1};
GN ORFNames=Y1Q_0024182 {ECO:0000313|EMBL:KYO36438.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO36438.1};
RN [1] {ECO:0000313|EMBL:KYO36438.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO36438.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- FUNCTION: Acts as a magnesium transporter.
CC {ECO:0000256|RuleBase:RU369007}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Co(2+)(in) = Co(2+)(out); Xref=Rhea:RHEA:28578,
CC ChEBI:CHEBI:48828; Evidence={ECO:0000256|ARBA:ARBA00036245};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Fe(2+)(in) = Fe(2+)(out); Xref=Rhea:RHEA:28486,
CC ChEBI:CHEBI:29033; Evidence={ECO:0000256|ARBA:ARBA00036243};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Mg(2+)(in) = Mg(2+)(out); Xref=Rhea:RHEA:29827,
CC ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00034269};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Mn(2+)(in) = Mn(2+)(out); Xref=Rhea:RHEA:28699,
CC ChEBI:CHEBI:29035; Evidence={ECO:0000256|ARBA:ARBA00036173};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ni(2+)(in) = Ni(2+)(out); Xref=Rhea:RHEA:29831,
CC ChEBI:CHEBI:49786; Evidence={ECO:0000256|ARBA:ARBA00036293};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU369007}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU369007}.
CC -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC {ECO:0000256|ARBA:ARBA00009749, ECO:0000256|RuleBase:RU369007}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU369007}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO36438.1}.
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DR EMBL; AKHW03002956; KYO36438.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NI15; -.
DR STRING; 8496.A0A151NI15; -.
DR eggNOG; KOG3788; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030001; P:metal ion transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 2.
DR InterPro; IPR006667; SLC41_membr_dom.
DR InterPro; IPR036739; SLC41_membr_dom_sf.
DR InterPro; IPR045349; SLC41A1-3.
DR PANTHER; PTHR16228; DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41; 1.
DR PANTHER; PTHR16228:SF25; SOLUTE CARRIER FAMILY 41 MEMBER 2; 1.
DR Pfam; PF01769; MgtE; 2.
DR SUPFAM; SSF161093; MgtE membrane domain-like; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU369007};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU369007};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369007};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369007};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369007};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU369007}.
FT TRANSMEM 68..87
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 99..124
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 168..190
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 202..220
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 291..309
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT TRANSMEM 361..384
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369007"
FT DOMAIN 22..155
FT /note="SLC41A/MgtE integral membrane"
FT /evidence="ECO:0000259|Pfam:PF01769"
FT DOMAIN 236..377
FT /note="SLC41A/MgtE integral membrane"
FT /evidence="ECO:0000259|Pfam:PF01769"
SQ SEQUENCE 395 AA; 42637 MW; FCCD4EEFD4EB38D6 CRC64;
MVLDIVQHWK VFKNVSEVFI LVPALLGLKG NLEMTLASRL STAVNVGKMD SPIEKWNLII
GNLALKQVQA TVVGFLAAVA AIILGWIPDG KYRLDHSILL CSSSVATAFI ASLLQGIIMV
GVIVGSKKTG INPDNVATPI AASFGDLITL AILAWISQGL YDCLETYYYI SPLVGAFFLA
LTPMGIVIAA KHPATRTVLH SGWEPVITAM IISSIGGLIL DTTVSDPNLA GIVVYTPVIN
GIGGNLVAIQ ASRISTYLHL HSIPGELPEE AKGCYYPCRT FYGTGVNNKS AQVLLLLVIP
GHLIFLYTIH LMKSGHTSLT PIFIAVYLFA ALLQVFTLLW IADWMVHHFW KKGKDPDSFS
IPYLTALGDL LGTALLAISF HFLWQIGDKD GDVGD
//
