ID A0A151NJW6_ALLMI Unreviewed; 706 AA.
AC A0A151NJW6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Centromere protein T {ECO:0000256|ARBA:ARBA00016401};
GN Name=CENPT-1 {ECO:0000313|EMBL:KYO36979.1};
GN ORFNames=Y1Q_0000856 {ECO:0000313|EMBL:KYO36979.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO36979.1};
RN [1] {ECO:0000313|EMBL:KYO36979.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO36979.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CENP-T/CNN1 family.
CC {ECO:0000256|ARBA:ARBA00010137}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO36979.1}.
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DR EMBL; AKHW03002899; KYO36979.1; -; Genomic_DNA.
DR RefSeq; XP_019344517.1; XM_019488972.1.
DR AlphaFoldDB; A0A151NJW6; -.
DR GeneID; 102567576; -.
DR CTD; 80152; -.
DR OrthoDB; 2919543at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051382; P:kinetochore assembly; IEA:InterPro.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR028255; CENP-T.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR032373; CENP-T_N.
DR InterPro; IPR009072; Histone-fold.
DR PANTHER; PTHR46904; CENTROMERE PROTEIN T; 1.
DR PANTHER; PTHR46904:SF1; CENTROMERE PROTEIN T; 1.
DR Pfam; PF15511; CENP-T_C; 1.
DR Pfam; PF16171; CENP-T_N; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 39..250
FT /note="Centromere kinetochore component CENP-T N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16171"
FT DOMAIN 598..694
FT /note="CENP-T/Histone H4 histone fold"
FT /evidence="ECO:0000259|Pfam:PF15511"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..533
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 706 AA; 78567 MW; FBBE81DD92EFD82D CRC64;
MPDPAAAPRT SASAGLGHDS GVSPSAVPRR AAEEWARPAP RRKHLSDSRK QKPTMAPDLE
TATPRLLLRK IFQTQPEVSP VVPKITEPWE PRESGSETHS ERLSNTSMKI QLPDLVSEDT
AIITFHTSRN KRKLSISEFE RAVDKRSSQN LAKSMSDDKS STRSLQASFS TPVPPNTIEK
RGLLRRPKNR KTVNVDSFEG GVEQNLLQIK DAENYLVDSQ AVSMIGTTVM MNDTKIALNN
TELFVQPQLS EKSQGRLSAL EPQLLARNVL ERGSRAFNTA EPESQKEHLA SNVDPEEEMV
PEDHEDSALD HADRSGPASV GKAGSPPRDH QDYAQQSSYA EQVSGLVSGI QKEPLTLNVN
PEEEMVQGDH EDSALYHTDR SSPASMGKAG SLPKDQQDCT QQSSYAEQVS GLVSGITELQ
SNMEYSEKLG EKLRKQTTSH INEKRQARTP VTPVEEEVMI EDAENQNSGK DVVEFPENAG
ARRLSRQSSA AFTRYSEPTR KKSIEPVEQT VDMDDGAVVE DTSELEEHKT EEEELSEDGA
KSEELSMEMP AFVHAMADQV SLSLSTPRSL KMAVPKLSPK PPPAKQAPKK NRTEQRRKRE
PALPSSLVKK IFRHYVKMPV ARDVFKVVEK CSEQYFKQLS NDLEAYTKHA GRKTVERADL
ELLMRRQGLV TDEMPLNVLI ERHLPLEYRK LLIPVATSGN KVIPSK
//
