ID A0A151NKC6_ALLMI Unreviewed; 2079 AA.
AC A0A151NKC6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
GN ORFNames=Y1Q_0008950 {ECO:0000313|EMBL:KYO37256.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO37256.1};
RN [1] {ECO:0000313|EMBL:KYO37256.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO37256.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO37256.1}.
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DR EMBL; AKHW03002792; KYO37256.1; -; Genomic_DNA.
DR RefSeq; XP_006258807.2; XM_006258745.3.
DR GeneID; 102560129; -.
DR KEGG; amj:102560129; -.
DR CTD; 253959; -.
DR eggNOG; KOG3686; Eukaryota.
DR OrthoDB; 21929at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR046859; RGPA/RALGAPB_N.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR PANTHER; PTHR10063:SF3; RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR Pfam; PF20412; RALGAPB_N; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 1790..1998
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 339..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2028..2079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..386
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..706
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..815
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2050..2079
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2079 AA; 234257 MW; C02E71237B18B741 CRC64;
MFSKKPHGDV RKSTQKVLDT RKDPLTRLKH LRVLIENAES IDLKQFFDLH FSHIYYVFFE
NFVTIEVGLR QKGHKSQREE LDGILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN
SLKIRREGVR LFLLWLQALQ NNCSKEQLWM FSCLIPGFSS PQSEYGPRTL DNLINPPLNV
QETQVTIEEI TPLVPPQSGD KGQEDLTSYF LEALLKYMVI QVKSLEWKNK ENQEKGFSFL
FSNFKKYYLP YIFPNICKET SLYNPVLEIP QMRPKPHYIM IKKDAETNEA ICCTKEPFLK
ARVIVIRWLV SFWLEPKPHA GPHIPGVEGE NVPKNIQRAA ASMASREDSK NDNSDRQDRN
AEPEQSHSNT STLTEREPSS SSLCSMDEEH LTDIEIVRKV FSSKRNNVNF LTEIFRQAFL
LPICEAAAMR KVVKVYQEWI QQEDKPLFMK EPEEIMQSTN IDCDENVAEH NSVETARERE
EEKTTNSSHI QNSSWTRNGC YQNISEVDIE EQSVRAGMQS VLQVFIINSS NIFFLEPANE
MKNLLDEHTD MCKRILNIYR HMVVQVTMDK KTWEQMLLVL LRVTESVLKI PPPTFLQYYG
RKNSTLAGRL AGPLFQTLIV AWIKANLNVY ISRELWDDLL SVMSSLTYWE ELATEWSLTM
ETLTKVLARN LYSLDLSDLP LDKLSEQKQK KHKGKGVGHE FQKSSVDKSF SRGWSRDQPG
QAPMRQRSAT TTGSPGTEKA RSIVRQKTVD IDDAQILPRP SRVRHFSQSE DTPSEVFGTL
NEEQPLPRSS STSDILEPFA VERAKVNRDD LSQKPHPVGS DIGSSNTNVP DLMDEFIAER
LRSGSALNVT RRGSSPGSLE VPKDLPDILN KQNQMRPIDD PGVPSEWTSP ASAGSSDLIS
SDSHSDSFSA FQYDGRKFEN FSFGTDAGTP ASTEIDAISG HQQSAEEQEV ASLTTLHIDS
ETSSLNQQPL SAEAATITGS ESASPIQSAL GSRSQTPSPA TLNADHIEQK DLQLDEKLHH
SVLQTPDDLE TSEFPSECCS VMAGGTLTGW HADVATVMWR RMLGILGDVN SITDPEIHAQ
VFDYLCELWQ NLAKIRDNLG ISTDNLTSPS PPILIPPLRI LTPWLFKATM LTDKYKQGKL
HAYKLICKTM KRRQDVSPNR DFLTHFYNIM HCGLLHVDQD IVNTIIKHCS PQFFSLGLPG
ATMLIMDFIV AAGRVAASSL LNAPRVEAQV LLGSLVCFPN LYRELPALHP NSPDIAVSQF
TDVKELIVKT VLSSAREEPS GPARCVALCS LGIWICEELV HESHHPQIKE ALNVICASLK
FPNKTVAHVA CNMLSMLIHY VHRLQAYQAD LPLKIIQILV ATITHLLPGT EASSYEQDKR
LVVSLLLCLL DWIMALPLKT LLQPVHTTDE NDKTEKSVLH CIFKVLHGCV YGAQCFGTPK
YFPLSFSDLA SMDYDPFMPL ESLKEPEPLH SPDSERSSKL QPVTEVKTHM QQGLISVAAR
TVVTHLVNHL GHYPMSGGPA MLTSQVCENN DNPYSESPEL SPELFESPNL QFFVLNNTSL
VSCIQIQAEE NMPGGGLSAG LVSANPNVRI IVRDLSGKYS WDSAILYGPS SLCGSSQQTA
FALSLYEQEK PDDAPSFSEF VEDVAIRDGI SLHAKRTFRE TVPTWDTIRD EEDALDELLQ
YLGITSPECL QRTGVSLNTP APQPICISEK QENDVINAIL KQDTEEREFV EKHFNDLNMK
AVEQNEPTPQ KPQSAFYYCR LLLSILGMNS WDKRRSFHLL KKNEKLLREL RNLDSRQCRE
THKIAVFYVA EGQEDKHSIL TNTGGSQAYE DFVAGLGWEV DLTNHCGFMG GLQKNKSTGL
TTPYFATSTV EVMFHVSTRM PSDSDDSLTK KLRHLGNDEV HIVWSEHTRD YRRGIIPTEF
GDVLIVIYPM KNHMFSIQIM KKPEVPFFGP LFDGAIVNGK ILPIMVRATA INASRALKSL
IPLYQNFYEE RARYLQTIIQ HHLEPTTFED FAAQVFCPAP YHHLPSDTGS CPETQLGETP
AAATAQVDGT DLASPMSPRT SKSRMSMKLR RSSGSANKS
//
