ID A0A151NLN7_ALLMI Unreviewed; 867 AA.
AC A0A151NLN7;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LATS1 {ECO:0000313|EMBL:KYO37704.1};
GN ORFNames=Y1Q_0022005 {ECO:0000313|EMBL:KYO37704.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO37704.1};
RN [1] {ECO:0000313|EMBL:KYO37704.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO37704.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO37704.1}.
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DR EMBL; AKHW03002600; KYO37704.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NLN7; -.
DR STRING; 8496.A0A151NLN7; -.
DR eggNOG; KOG0608; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd21778; MobB_LATS1; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR049761; LATS1-like_MobB.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR24356; SERINE/THREONINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR24356:SF138; SERINE_THREONINE-PROTEIN KINASE LATS1; 1.
DR Pfam; PF00069; Pkinase; 2.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:KYO37704.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transferase {ECO:0000313|EMBL:KYO37704.1}.
FT DOMAIN 45..86
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 443..748
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 105..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..213
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..258
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..369
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 98217 MW; A928A3D36F15FA1F CRC64;
MSTEDPRQGR NPPKFVMYHK ALQEIRNSLL PFANETNSSA KGTSDVNRQM LQDLQAAGFD
EDMVVQALRQ TNSRSIEAAI EFISKMSYQD PRREQMVAAA ARPVNAGMKP PAGSVQQSVN
RKQSWKGSKE SLVPQRHGPP LGDGVVYRSE SPSSQSDVGR PLSGSGITAF AQAHSVNGQR
VNPPPPPQMR SVTPPPPPPR GQTPPPRGTT PPPSSWEPNS QTKRYSGSME YMISRISPVP
PGAWPDGYPP PPMNPPPINT STQGQRGISS VPIGRQPIIM QSSAGKAPNY QGPPPPYPKH
LLHQTQSISP YESGTKPSKD DQSALPKEDE SEKNYECIDG ADKEKKQITT SPVPVRKNKK
DEERRESRIQ SYSPQAFKFF MEQHVENILK CHQQRLHRKK QLENEMMRVG LSPEARDQMR
KMLCQKESNY IRLRRAKMDK TMFVKIKTLG VGAFGEVCLA RKVDTNALYA TKTLRKKDVL
LRNQVAHVKA ERDILAEADN EWVVRLYYSF QDKDNLYFVM DYIPGGDMMS LLIRMGVFPE
NLARFYTAEL TCAVESVHKM GFIHRDIKPD NILIDRDGHI KLTDFGLCTG FRWTHDSKYY
QSGDHPRQDS MDFSNEWGDP ASCRCGDRLK PLERRAARQH QRCLAHSLVG TPNYIAPEVL
LRTGYTQLCD WWSVGVILFE MLVGQPPFLA QTPSETQMKV INWQTALHIP PQAKLTPEAS
DLIIKLCRGP EDRLGKNGAD EIKVHPFFKT IDFSSDLRRQ PAFYIPKIAY PTDTSNFDPV
DPDKLWSDEK EGNVNDTLNG WYKNGKHPEH AFYEFTFRRF FDDNGYPYNN PKPIEYEYSN
PRNLEQQSDD DNGQAGKGVQ NRDLVYV
//
