ID A0A151NN27_ALLMI Unreviewed; 1014 AA.
AC A0A151NN27;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Diaphanous-like protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Y1Q_0007291 {ECO:0000313|EMBL:KYO38183.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO38183.1};
RN [1] {ECO:0000313|EMBL:KYO38183.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO38183.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO38183.1}.
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DR EMBL; AKHW03002528; KYO38183.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NN27; -.
DR eggNOG; KOG1924; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR044933; DIA_GBD_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF3; PROTEIN DIAPHANOUS HOMOLOG 2; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 76..449
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 541..941
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 964..994
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 983..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 496..523
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 916..962
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 18..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..1004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1014 AA; 117217 MW; 7B32BA462E3E283D CRC64;
MESAAAEDAP GRAGTRRAGR GAAEEESKNK PKLRDRLTSL RKSAVKKEKP LIQHPIDSQA
SVSELPVAQP LIDERSMNLS EKEVMDLFEK MMEDMNLNEE RKAPLRNKDL TTKREMVVQY
ISATAKSITG SKVLGGLKNS KHECTLSSQE YVHELRSGIT EEKLLNCLES LRVSLTSNPV
SWVNNFGHEG LGLLLDVLER LLDKKQQETI DKKNQNKLIQ CLKAFMNNKY GLQRILGDDR
SLLLLARAID PKQPNMMTET VKILSAICIV GEENVLDKLL EAITTAAERN NRERFSPIVE
GLENHEALQL QVACMQFINA LVTSPEDLDF RIHLRNEFLR CGLKKILPGL KKKENEELDI
QLKVFDENKE EDLIELSHRL NDIRTEMDDM NEVYHLLYNM LKDTSSENYF LSILQHLLLI
RNDYYIRPQY YKIIEECISQ IVLHCSGMDP DFICRGRLDV DFTHLIDVCV DKAKVEESEQ
KAAEFSKKFD EEFSARQEAQ TELQKREEKI KELEIEIQQL RTQGPGLHSR FPVSLPYGMK
EKKKYKPEVT MKRINWSKVE PQEISEHSFW VKANENKYEN PDLLSKLRLT FGTQMKARRA
VEDMEEKKIV MPKKRGKELR ILDGKTAQNL SIFLGSFRMP YEEIKNIILE VDEMKLSESL
IQNLVKNLPE QKELSALAQL KDEYADLCEP EQFGVVMSSV KMLRPRLNGI LFKLMFEEHV
NNIKPGIMAV TLACEELKKS ESFSRLLELV LLIGNYMNSG SRNAQSLGFN VSFLCKIRDT
KSSDQKTTLL HFLAEICEEN YRDILKFPDE LEHVESASKV SAQCLKSSLD TMEHQIQRLE
SDIEKFPKTE DTHDKFVEKM SSFSKNARDH YEKLSNMHNN MIKLYENLGE YFSFDPKATG
IEEFFGDLSS FRTLFLEALK ENNKKKEMEE KIKRAKLAKE KVEREKLERQ QKKKQLMDMN
KEGDETGVMD NLLEALQSGA AFRDRRKRTP RCQDNRRVTL ERSRSRHNGT ITAV
//
