ID A0A151NP38_ALLMI Unreviewed; 777 AA.
AC A0A151NP38;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Pendrin {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Sodium-independent chloride/iodide transporter {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 4 {ECO:0000256|RuleBase:RU362052};
GN ORFNames=Y1Q_0023340 {ECO:0000313|EMBL:KYO38616.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO38616.1};
RN [1] {ECO:0000313|EMBL:KYO38616.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO38616.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- FUNCTION: Sodium-independent transporter of chloride and iodide.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO38616.1}.
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DR EMBL; AKHW03002440; KYO38616.1; -; Genomic_DNA.
DR RefSeq; XP_006257881.1; XM_006257819.2.
DR AlphaFoldDB; A0A151NP38; -.
DR STRING; 8496.A0A151NP38; -.
DR GeneID; 102576042; -.
DR KEGG; amj:102576042; -.
DR CTD; 5172; -.
DR eggNOG; KOG0236; Eukaryota.
DR OrthoDB; 1067648at2759; -.
DR PhylomeDB; A0A151NP38; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF33; PENDRIN; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 110..127
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 134..153
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 184..209
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 216..237
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 293..314
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 342..361
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 382..405
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 417..435
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 476..504
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 532..726
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 751..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 85257 MW; A5B490AD9FFD67B3 CRC64;
MAAGDRAEAP AGEPGPYVVA RPVYSEAAFQ EEHERRPPLP PTLRERAQRA CSCSRKKAFQ
ITKSFIPILE WLPNYRVKEW LISDIISGIS TGLVATLQGL AYALLVAVPV GYGLYSAFFP
ILTYFFLGTS RHISVGPFPV VSLMVGSVVL SMAPDENFLL VSSNTTGLNK TLIDTESRDA
QRVLIASTVT FLVGIMQLVL GALQIGFIVR YLADPLVGGF TTAAAFQVFV SQLKIVLNVS
TKNYNGILSI IYTLIEIFER IGTTNIADLV AGLLTIVVCM AVKEINDRFK HKIPIPIPIE
VIVTIVATGI SYGADLEKKY NAGIVKNIPR GFLPPVPPVV SMFSQMAAAA FSIAVVAYAI
AVSVGKVYAT KYDYAIDGNQ EFIAFGISNV FSGAFSCFVA TTALSRTAVQ ESTGGKTQVA
GLISAGIVMI AIVALGKLLE PLQKSVLAAV VIANLKGMFM QVCDVPRLWR QNKVDAMIWV
FTCVASIILG LDLGLLAGLV FGLLTVVVRV QFPSWGGLGN VPGTDLYKNV KEYKNVVEPQ
GVKILQFSSP IFYANIDGLK SSLKSTVGFD AVRVYNKRLK ALRKIQKLIK KGKLKATKNG
IISDSGVANE AFEPDEDPEE SEDLEIPTRE IEIQVDWNSE LPVKVNVPKV PIHSLIFDFG
AVSFLDVVAV RSIRTIVKEF ERIDVRVYFA SHQDSIITKL EQCAFFDDNI RKDIFFLTVH
DAVLHIKSQI MYKDIQDPIF EKISLMQESK EPIEFTETSR PEDELDVQEE AMRRLAS
//