ID A0A151NST2_ALLMI Unreviewed; 1240 AA.
AC A0A151NST2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Tumor necrosis factor ligand superfamily member 6 {ECO:0000256|ARBA:ARBA00018020};
DE AltName: Full=Fas antigen ligand {ECO:0000256|ARBA:ARBA00030913};
GN Name=SUCO-1 {ECO:0000313|EMBL:KYO39813.1};
GN ORFNames=Y1Q_0006691 {ECO:0000313|EMBL:KYO39813.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO39813.1};
RN [1] {ECO:0000313|EMBL:KYO39813.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO39813.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- FUNCTION: Cytoplasmic form induces gene transcription inhibition.
CC {ECO:0000256|ARBA:ARBA00003149}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle lumen
CC {ECO:0000256|ARBA:ARBA00004321}. Lysosome lumen
CC {ECO:0000256|ARBA:ARBA00004227}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO39813.1}.
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DR EMBL; AKHW03002184; KYO39813.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NST2; -.
DR eggNOG; KOG1396; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0060205; C:cytoplasmic vesicle lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR028326; FASL.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR045120; Suco/Slp1-like.
DR InterPro; IPR012919; SUN_dom.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR12953; MEMBRANE PROTEIN CH1 RELATED; 1.
DR PANTHER; PTHR12953:SF0; SUN DOMAIN-CONTAINING OSSIFICATION FACTOR; 1.
DR Pfam; PF07738; Sad1_UNC; 1.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01681; FASLIGAND.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS51469; SUN; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 931..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 229..391
FT /note="SUN"
FT /evidence="ECO:0000259|PROSITE:PS51469"
FT DOMAIN 1105..1240
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 16..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1071..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1240 AA; 138801 MW; BE51AAD4C91DA376 CRC64;
MCQSWLPSWH VFCKESSSPT LRYSPDDCAL ANEDENIQEK EEMGRPTGTQ SLEHVDSSVQ
SYPREDVFGD TKYDQTTEMG ELSLPEAETP LPSVDLNEAA SSIAASIENI SSPSTSEISP
VSHPDAIENS SADIPVVSSN EAEQSEPDCD IGGALEADPQ SEPSSFVSPP EGLVGQHIEN
ISSSHGKGKK TKSEFESEVS ATEKSADEQK SALNASDNLK REKDYKAGEV DPKDPGDIPT
FDEWKKQVME VEKEKSQSMH PSSNGGQHST KKSTSAILME NMDLYMLNPC STKIWFVIEL
CEPIQVKQLD IANHELFSST PKDFLVSISD RYPTSKWIKL GTFHARDERN VQSFPLDEQM
YAKYVKVELV SHFGSEHFCP LSLIRVFGTS MVEEYEEIAD SQYQSERQEL FDEDYDYPLD
YNTGEEKSSK NLLGSATNAI LNMVNIAANI LGAKTEEISE AEGKKSLSEN TTAINATSTV
APKLPEPTPV PSPELVTTEI PEIEKEQPTL ATTQSPIVQL VQEYEEEASQ STVTLLPSDE
QEEETTPWFE SETQTYCYDL ANVCCISSFS EYLYKWCSVI VALHRQHSKT DGKQEGEYSA
IVQYPQLVPT ESLHVAVEEP LPEKLDGKIM DRLPGSTIAN ELNVILEDVS NQTVESIELE
PSLPQTVSQS LLVEVTSEVK PLPTIEVSLE STKKEVGQAV SPVTPQEDTV EMIDEAEKRV
DGSFTVEKHS VVSETNTVTE FQETSTKYMT PVQIISKPTE TVPQPEYTTT AIPVTIAEIK
EDEQTPEEAF LAIPVSGGQQ RAATDFYAEL QNSTDLGYAN GNLVHGSNQK ESVFMRLNNR
IKALEVNMSL SSRYLEELSQ RYRKQMEEMQ KAFNKTIIKL QNTSRIAEEQ DQRQTEAIQL
LQMQLNNMTQ IVSNLSTTVA ELKREVSDRQ SYLVIALVLC LILVLILCMQ RCRNASQFSE
DYHSKIPQSN NYPSPKRCFS SYDDMNLKRR TSLPLVRSQS FQLTGKEVDP GDLYIVEPLK
FSPEKKKKRC KYKSEKIETI KPAAEPLHPI ANGEIKGGKP FTNQRDFSNI GEATSPGHLP
PAAEKHTGLP NATEKIMEKK EVRKAVHLTG KSGQKGLPLE WEAIYGHAFT SSIQYKQGSL
MINETGLYFV YSSVFFRGEV CNNQPLDHTV YKRNPGYPGN QVLMEDRRMN YCATQKMWAG
NSYLGALFNL TRMDRLYVNV SRIALVHFEE SKTFFGVFKL
//
