ID A0A151NYJ8_ALLMI Unreviewed; 901 AA.
AC A0A151NYJ8;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Potassium voltage-gated channel subfamily KQT member 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Y1Q_0002616 {ECO:0000313|EMBL:KYO41952.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO41952.1};
RN [1] {ECO:0000313|EMBL:KYO41952.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO41952.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO41952.1}.
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DR EMBL; AKHW03001485; KYO41952.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NYJ8; -.
DR STRING; 8496.A0A151NYJ8; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:UniProt.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR020969; Ankyrin-G_BS.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR003947; K_chnl_volt-dep_KCNQ2.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735:SF4; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2; 1.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF16642; KCNQ2_u3; 1.
DR Pfam; PF03520; KCNQ_channel; 2.
DR Pfam; PF11956; KCNQC3-Ank-G_bd; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01461; KCNQ2CHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 93..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 95..322
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 456..603
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT DOMAIN 614..676
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 435..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 681..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..762
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 901 AA; 99795 MW; D88E0CBF8F3C5284 CRC64;
MVQKSRNGGV YPGPAGEKKL KVGFVGLDPG APDSSRDGAL LIAGSDSTKR GSILSKPRSG
GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIDEYQN
SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI
AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELITAWYIGF
LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI
GVSFFALPAG ILGSGFALKV QEQHRQKHFE KRRNPAAGLI QAAWRFYATN LSRTDLRSTW
QYYERTVTVP MYRLIPPLNQ LELLRNLKSK SGLTFRKEQQ PEPSPSKSKP CRESFCGCCS
GNSSQKVSLK DRVFSSPRGA GAKGKGSPQA QGVRRSPSAD QSIEDSPSKV PKSWSFGDRS
RARQAFRIKG AASRQNSEEA SLPGEDIPDD NKSCNCEFVT EDLTPGLKVS IRAVCVMRFL
VSKRKFKESL RPYDVMDVIE QYSAGHLDML SRIKNLQSRI DMIVGPPPPS TPRHKKYPTK
GPMFSSKESP QYSPRVDQIV GRGPSMTDKD RTKGPAEGEL PEDPSMMGRL GKVEKQVQSM
EKKLDFLVNI YMQRMGIPPT ETEAYFGSKE PDPAPPYHSP EESREHIDKN GCIIKIIRST
SSMGQKNFSA PPAPTMPTNT CPPSTSWQHQ PYQRQSHGSS PVGDPGSLVR IPPPPSHERS
LSAYGSGHRA SAEYLRNDDV TTKHHESAMR DSDTSISIPS VDHEELERSF SGFSISQSKE
NLDILNNGCY ASVAPCAKIR PYIAEGESDT DSDLCTPCGP PPRSATGEGP FSDMGWSAPR
Q
//
