ID A0A151NYP3_ALLMI Unreviewed; 3663 AA.
AC A0A151NYP3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Laminin subunit alpha-5 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Y1Q_0002648 {ECO:0000313|EMBL:KYO41992.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO41992.1};
RN [1] {ECO:0000313|EMBL:KYO41992.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO41992.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO41992.1}.
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DR EMBL; AKHW03001485; KYO41992.1; -; Genomic_DNA.
DR eggNOG; KOG1836; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 19.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 16.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009254; Laminin_aI.
DR InterPro; IPR010307; Laminin_dom_II.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR PANTHER; PTHR10574:SF365; NETRIN-A-RELATED; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 20.
DR Pfam; PF00054; Laminin_G_1; 2.
DR Pfam; PF02210; Laminin_G_2; 3.
DR Pfam; PF06008; Laminin_I; 1.
DR Pfam; PF06009; Laminin_II; 1.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 14.
DR SMART; SM00180; EGF_Lam; 22.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00282; LamG; 5.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 19.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01248; EGF_LAM_1; 9.
DR PROSITE; PS50027; EGF_LAM_2; 14.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
DR PROSITE; PS51115; LAMININ_IVA; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 13..266
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 396..440
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 462..508
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 509..554
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 555..599
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 600..644
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 645..690
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 742..794
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1400..1445
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1490..1538
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1539..1589
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1610..1788
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT REPEAT 1802..1850
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 1802..1850
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 1822..1871
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1928..1981
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1982..2028
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2029..2075
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 2907..3083
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3090..3258
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3312..3477
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 3484..3660
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 3257..3294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2162..2210
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2266..2417
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2519..2647
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 416..425
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 462..474
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 485..494
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 509..521
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 511..528
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 530..539
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 555..567
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 575..584
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 600..612
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 620..629
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 645..657
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 647..664
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 666..675
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 765..774
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1400..1412
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1402..1419
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1421..1430
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1514..1523
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1539..1551
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1541..1558
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1560..1569
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1841..1850
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1953..1962
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1965..1979
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2001..2010
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2049..2058
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 3663 AA; 403381 MW; 47B1F34247E15872 CRC64;
MKNRTRDSAI AFICGRKAPG SDDDDGLRTR IAATATCGED GGALEDLYCK LVGGPVAGGD
PHHTIQGQYC DICSSANSNK AHPISNAIDG TERWWQSPPL SRGLEFNEVN VTLDLGQLFH
VAYVLIKFAN SPRPDLWVLE HSTDFGLTYE PWQYFASSRR DCIEKFGPRT VERVTKDDDA
ICTTEYSRIV PLENGEIVVS LVNGRPGAMN FTYSPLLRNF TKATNIRLRF LRTNTLLGHL
MGKALRDPTV TRRYYYSIKD ISIGGRCVCH GHADVCDAKD PNDPYRLQCD CQHNTCGGSC
DRCCPGFNQV PWKPATSDSA NECQPCNCNG HAYDCYYDPE VDHHKASKSH EDMYEGGGVC
IDCQHHTTGI NCERCISGYY KSPDHPIDSP YICYRCNCDS EFTDGTCEDL TGRCYCKPNY
TGERCDACAE GYIDFPHCYP VPAFSHNDTG EQVLPAGQII NCDCYAAGTE GNACRKDSRT
GVCVCKPNFQ GAHCDQCAPG HYGPSCQPCQ CSGPGQYEGT CDSETGQCLC RSGFEGQSCN
QCAPGYFSYP LCQLCGCSAV GTLPGGCDSV GRCFCKPEFD GPHCDRCSTG YHSYPHCHAC
SCDPRGSVDN TCSPAGQCRC HLNFAGHTCS QCAPGFYGYP SCTPCQCSAE GSLHGTCDQE
MGQCSCRPKV TGLRCDTCVP GAYGFPHCEV GSCNPAGLES TDPSLPLGSC ACRAYVEGPA
CDRCKPLYWN LTPENPYGCT SCQCNTKGTI SGVAECQQGS GQCFCKPNIC GQLCSTCKDG
YFKLNRASYF GCQGCQCDVG GSVGPSCEKT GACHCRPNTR GPTCTQPAKD HYFPDLHHLK
LELEEGTTPD GRAVRFGYNP LEFENFSWRG YAQMSPIQNK VRVTVAVKEA ELSLFHVILR
YINSGGATVY GKITAFQPRR RGTEQTKQIV FAPSTEPAFV TVPQNSFGEP FVLNPSVWSL
IVEAEGILLD YLVLLPSSYY EAPILQLKVT EACTYRPSPE QASRNCLLYK YLSADGFPSA
SGADAVCRID NNLPRPCPVE LITPSHPRMV LCSGSDVEVQ VRLPIPQPGK YVVLVEYANT
DGQQTAGVAV TSPQQAPQQG TSTFYTCDYS FLCRGMVVDS ENRLATFELR REATVRFTAD
RAHVFLHKVY LIPHRRFTME FVEPKVHCIS LHGTFSPNSS SCVPSRFPKL SQSIVLEGGQ
PVLIPLDLPL THAFSVTPTG PTTGPPPRPP TAVDSSAELI LLQPPQTAVV FNTRIQTLGR
YTFILHCYQP NHPTFPVEVL INGGRIWQGQ ANATFCPHGY GCRSLVVAEN HIVLDVTDND
LSVIIRVPED RQLWLDYILV VPEDSYSSQY LQEEPLDKSY DFISTCGVNG FYINPATSPR
FCKDSAISLS LFYNNGAQPC RCHEVGAVSR QCEPFGGQCT CKSNVIGREC SRCATGYWGF
PNCRPCDCGL RLCNEVTGQC ICPPHTIKPE CVVCEPQTFG CHPLVGCEDC NCSRPGVQEL
TEPGCDVDSG QCRCKPNVIG RRCNLCAPGY YHFPDCRSCN CHPAGTEASV CDPVTGQCHC
KENVEGPRCD QCRLGTFLLD ADNPKGCTKC FCFGATDRCH SVEKYRVEFS DMNGWRLLSS
DRQEVGTSLR AEEDLVHADL KYLLEVYQEL YWQAPSSYLG DRVSSYGGHL RYELHSDARR
GDVFVPMESR PDVILKGNQM SIMFREDTYP PPGDVHRGQL QLVEGNFRHT ETHNPVSREE
LMMVLASLEQ LQIRALFSQI SSSIFLRRVI LETVTDSAVG IRASNVELCL CPANYRGDSC
QECAPGYYRD TKGLFLGKCV PCHCNGHSDQ CLPGSGICIN CQHNTEGNRC ERCKDGYVDS
YSPEGLLQCV GCPCPLSVAS NNFAVGCIRK GSTMQCLCKT GYAGAMCERC APGYYGNPLV
IGSFCQPCDC SGNTDPNMLF SDCDPLTGAC SGCMHHTAGP RCELCAPGYH GDAVEAKNCT
LCSCSPCGTE SCDPRTGRCL CKAGVTGQHC DRCQEGYYGY DSCSGCRRCD CDVGSLGASC
HTQTGQCSCQ PGVNGARCHQ CAPGYWGLGE NGCTKCQCKG GSCDPRTGEC TCPSGLTGKQ
CDTCIQQYEI PVASGPDSVR CEVCDTCVLL LLEDLRKIEA SFPTIRNQLI NLNASSIAWA
RLHGLKNTME TLANHLREHQ RSMSGVRQRA EELVEENRDL TQDLNALQHK MTMTHRKANS
LDEHTKNTYQ RVQQLLLNIR SIQNSIQELG HQMDMFGTGN VSATSTEEFR QKMAEVERML
KEMRERDFSS QRGLAENEEE EAQKLLHRVQ NELHSKGEAN RALVNNIRDR LTQYNSELMD
LRDALNEAVN KTRQTEDLNS MNLNNLEESQ RKKKELQKQH GLVQDTLRMA EDSLAQVSDL
LQMIERAKED YEKLAALLDG AKHPLTERVK KFSPASSKIP VVEAAEEHAR FLDELARNLS
SIIRSTNQDG FIQRAIDASN AYASIIEAVK KAETAAADAA DAASEALMGV VSGDLAAIAK
KLKRNSSALE EAVRQEQRKL SGPIKGTLQA AREKVTDLRA RKDRLVTRLR AVQDMLEVDQ
DGTKEAIQNA KDAAAKANET AARVQDTLNS MKKNLDEWKD QYGDLRNEDL HQAVQDAKKS
VSSLESTIPL LLGKLSNLEN RKNKNATVSE NIVRIRQLIT QARNAASKVK VPMKFNGQSG
VQVRSPSDLP DLAAYTSLKF YIQNPEPSSA SAPARRQGGP DEGRFVLYLG SKEGTGDYMG
VVLKDRKVQW VYQLGDEEPT FLTIDEEIGE QFAVVSINRI LQYGHMSVTM EKKTLHETKG
DSVAKGEQGL FNFDLHSVVF YVGGYPSSFM PPATLHYPGY QGCIELDTLN EEVVSLYNFH
HTFHLDTATE KPCARSKSTG DPWLTDGSYF DGTGYAEIKF ESQIGPTKRF EQEMRMVSYN
GILFFLEHEG QFLCLAVQDG KLVLYYDFSD GLKVAESNNN LALLTVSSTT NKAVQIYLLK
MDNKKRILVR LERLTIFIVE QENSLENAVS YYLGGVPLSV LPESLKAIFP KGGSIRGCMK
GLKALGKYVD LKRMTTTGVS YGCTSDLLVA RSVKLHGHGY LTLSLKNVPP LQDFYTGFSF
RTSQSDGLLY YHATAEGKCQ VSLKSGQLAL EVLRTALTTQ NTYADDSSHY VAVYSDASGV
RLYVDDELQE ATQAAEGASR QGLQEEQLRF QLGGLPETGA LSNLTGCIGN VFVRRKSDPQ
MVVDLQQNVE SFNVTMSCPR DQQPQQMQVS PKKDRRKPKG PSRPSRLALK GRRQSQEMTC
LLPRHPRAAR GAFQFGGFSM SRLEFDDIPE SFQEKSYFSM EVRLNATSGL LFYVASEQPG
SFMAVLVSNG RFVLLADLGG NKLRIQSKDK YHDRRWHTVF FSRDGRRAQL VIDGLKAQDA
TMATAGQFLX XXXLTWPRGA QLSWDTSVTS FSGCLRNLKL DQHPLPSPSR TFGVTRCYEG
ALESGVFFAA EGGHVTLANA VSLEQDISLK LEVRPRSAAG LIFHIGRTRS YLSLSMDDKK
VLLKANSGAG EFSTWVAHPA LCDGQWHAIT VTKQRNMIHV AVDRVGNNTV GPSQTHWAEH
KEPLHVGRMP ETTKLGAASP SPLTPLPHYI GCIRNLMIDQ HLIDLPGTAT VRGSVGLRGC
PVL
//
