ID A0A151NZH3_ALLMI Unreviewed; 997 AA.
AC A0A151NZH3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Insulin-degrading enzyme isoform B {ECO:0000313|EMBL:KYO42296.1};
GN Name=IDE {ECO:0000313|EMBL:KYO42296.1};
GN ORFNames=Y1Q_0022162 {ECO:0000313|EMBL:KYO42296.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO42296.1};
RN [1] {ECO:0000313|EMBL:KYO42296.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO42296.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO42296.1}.
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DR EMBL; AKHW03001467; KYO42296.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151NZH3; -.
DR eggNOG; KOG0959; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 54..189
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 216..394
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 400..680
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 684..867
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 997 AA; 115555 MW; 7112BF9B0C7F04A3 CRC64;
MRQLLLRRLS RLQKEINSKM RSSAIKRITN EIIKSPEDKR EYRGLELANG IKSLLISDPT
TDKSSAALDV HIGSLSDPLN IAGLSHFCEH MLFLGTEKYP KENEYSQFLS EHAGSSNAFT
SGEHTNYYFD VSHEHLEGAL DRFAQFFLCP LFDESCKDRE VNAVDSEHEK NLMNDAWRLF
QLEKATGNPN HPFSKFGTGN KFTLETRPTK EGIDVRQELL KFHSTYYSSN LMSICVLGRE
SLDELTSLVV KLFSEVENKN VPIPEFPEHP FQEEHLQQLY KIVPIKDIRN LYVTFPIPDL
QKYYKSNPGH YLGHLIGHEG PGSLLSELKA KGWVNTLVGG QKEGARGFMF FIINVDLTEE
GLLHVEDIIL HMFQYIQKLC TEGPQEWVFQ ECKDLNAVAF RFKDKERPRG YTSKLAGMLH
YYPIEEVLAA EYLLEEFRPD LIEMVLDKLK PENVRVAIVS KSFEGKTDRT EQWYGTQYKQ
EAISDEVIKK WQNADLNGKF KLPMKNEFIP TNFEILPLEK DAAPYPALIK DTAMSKLWFK
QDDKFFLPKA CLNFEFFSPF AYVDPLHCNM AYLYLELLKD SLNEYAYAAE LAGLNYDLQN
TIYGMYLSVK GYNDKQHILL KKIIEKMATF EIDEKRFEII KEAYMRSLNN FRAEQPHQHA
MYYLRLLMTE VAWTKDELKE ALDDVTLPRL KAFISQLLSR LHIEALLHGN ITKQAALGIM
QMVEDTLIEH AHTKPLLPSQ LVRYREVQLP DRGWFVYQQR NEVHNNCGIE IYYQTDMQST
SENMFLELFC QIISEPCFNT LRTKEQLGYI VFSGPRRANG IQGLRFIIQS EKPPHYLESR
VEAFLKTMEK CIEDMSEEAF QKHIQALAIR RLDKPKKLSA ECAKYWGEII SQQYNFDRDN
TEVAYLKTLT KDDIIQFYKE LLAVHAPRRH KVSVHVLARE MDSCPVVGEF PCQNDVNLAP
APPLPQPSVI ENMTEFKRSL PLFPLVKPHI NFMAAKL
//
