ID A0A151P2H9_ALLMI Unreviewed; 527 AA.
AC A0A151P2H9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
GN ORFNames=Y1Q_0017447 {ECO:0000313|EMBL:KYO43109.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO43109.1};
RN [1] {ECO:0000313|EMBL:KYO43109.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO43109.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO43109.1}.
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DR EMBL; AKHW03001210; KYO43109.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151P2H9; -.
DR STRING; 8496.A0A151P2H9; -.
DR eggNOG; KOG3594; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 3.
DR Gene3D; 2.60.40.60; Cadherins; 3.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF96; CADHERIN-12; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 3.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 3.
DR SUPFAM; SSF49313; Cadherin-like; 3.
DR PROSITE; PS50268; CADHERIN_2; 3.
PE 4: Predicted;
KW Calcium {ECO:0000256|PROSITE-ProRule:PRU00043,
KW ECO:0000256|RuleBase:RU003318};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transmembrane {ECO:0000256|RuleBase:RU003318, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 339..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..117
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 118..222
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 222..340
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 527 AA; 58604 MW; 2C2372EA8AE3BD48 CRC64;
MSRGGIFHLK VPESSPVGSA IGRIRAVDPD FGENAEIEYN IVPGDGGNLF DITTDENTQE
GVIKLKKPLD FETKKAYTFK VEASNLHLDH RFHSVGPFKD TATVKINVLD VDEPPIFSKP
MYTMEVYEDT PVGTIIGAVT AQDLDVGSSS VKYFIDWKSD VDSYFTIDAT EGTIATNELL
DRESTAQYNF SIIASKVSNP LLASKVNVII NVLDVNEFPP EISVPYETSV CENAKPGQVI
QTVSAADKDL SPAGQRFSFR LSPEASTKPN FTVHDYRNNT AGIETRRSGY SRRQQELYFL
PVVIEDSSYP VQSSTNTMTI RVCRCDSDGT ILSCNVEAIF LPVGLSTGAL IAILLCIVIL
LVIVVLYVAL RRQKKKDTLM TSKEDIRDNV IHYDDEGGGE EDTQAFDIGA LRNPKVIEDN
KIRRDIKPDT LCFPRQRPPV EDNRDIRDFI NQRLQENDVD PTAPPYDSLA TYAYEGNGSV
AESLSSIDSL TTEADQDYDY LSDWGPRFKV LAEMFGEEES YNPDKVT
//
