ID A0A151P2V5_ALLMI Unreviewed; 2180 AA.
AC A0A151P2V5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=Y1Q_0013474 {ECO:0000313|EMBL:KYO43401.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO43401.1};
RN [1] {ECO:0000313|EMBL:KYO43401.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO43401.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO43401.1}.
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DR EMBL; AKHW03001146; KYO43401.1; -; Genomic_DNA.
DR RefSeq; XP_019338558.1; XM_019483013.1.
DR GeneID; 102559868; -.
DR OrthoDB; 4199487at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR CDD; cd10571; PH_beta_spectrin; 1.
DR CDD; cd00176; SPEC; 3.
DR Gene3D; 1.20.58.60; -; 4.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF445; PH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00435; Spectrin; 3.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00150; SPEC; 6.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 4.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1878..1986
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 59..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1080..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1333..1415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1611..1640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1750..1777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1809..1834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1849..1873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2048..2085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2145..2180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 212..239
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 285..348
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 926..953
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1014..1041
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 123..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1347..1362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1400..1415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1857..1873
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2050..2080
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2180 AA; 240415 MW; 9E7301555CA19A81 CRC64;
MSGSTVRKVQ PFTISTKLSL PKCAADCPGD PCPDVAMAAL DNRGLRHNLN ERVSLYLAQS
QAAPGPPEGR VQSTSPMEEG VTDEDRLNRN SLARSIKKIT LSNWHGEPGP GEDGVARDPA
HASCQRNHNN NNSRPGKAPF KLSGSHAAAP WKESIKTKEP GGMAWLKTGL RNSTGQANPN
LTPLLAQFNQ EIMQAENWVQ GKLRDLKDGC EIQDWERVAQ NLQRDMKDFE NALIKLNQMG
EQLMGWPSPS VETVRRQLLA LREQWQLLKQ TASNQSKALG GLRSLQEFNT KAEQLEAWIR
QKEEKPMLAA LLQQSLDKIQ LTRRILDLKQ EEQRFHGLHE EMNTLAQRLE KQGRSESRSI
SARRKHLNKM WLRLQGTLKE HHETLQLALE AAAFIQQADM LLKAIHAKWR SLYGVGKQGE
ADPSREQDVR DIASQVMILD VTVSQLISLH PSLVARVTHK HRDVKESWAR LQEVLRNEKS
PVQSLTSSSP REALSPEQTG GSSEGVAGNE AGDKKKRVPG NEVQKDVSGS VTEHVRGEEG
SPGLPGGHLA QGCHSSKRRK LPGHSDAGWG VPQQESQLQN YCQAANMAIS WLKEGAGPGI
QQNQVEDAEN LEALQSHQEI LGNSTGLEAV CQEGQKLFHT CPRGSPEVEG VLRELVGLWE
ELQRKHQENG AVLREIDKAL QLVGELDRAE HWLQGVAGSL SEPAAMKNPE ELRRDLQDIG
SLENQLLLWG IRLQALREEM GREPSTGHEA AGRIQRKVET VEEKLRCVRA ALRRRASDLR
DSLVLSEFLQ NVQQEEVLSQ KSRVQPVTHQ LDPKEPLHLL LVQAGQQLNR EGMSSPLGEL
QEAVEMLNDA VKERERVMEA AAETESLERL LAEVSLHMQA VRCRAETLAR DIAQAERGFA
TVKSEWDLQG LQGLLSRQQD MEREMSEALE GHLEELQRAA THLEKLCATQ RRDLVPEVQE
TLKAGEGLLA LVLENKARME QAGQLRQFFR DYLAMISWTE DTRAQIFSEN LSTHGLLEAQ
CEELERKIED KFMEFEELAA AGQKLVSEEH DLSETIQERM EELQSMLGWV LVRWRAQKHQ
LDPGSKSDGG KGQDNPLDST QSAFPGSQDR HTSSVLPDAK SLLGPNASKG PQPSSCSFLE
PLTPPQDLKA QPQRQEEEVV PPSVLPVPRR ELSWEGPGDS TPLEIGIPKE TLVNPSKTPV
VVVPPRGPSS VGGTVSLILS IGKKGDKRLQ LAQAGAEQGE EALHKVSAYL CVKENEGVGS
ATHKSSTVLH PAKQAPARSH ASLVSSTGAD TAFHTLPKAS SSSLMDSLQR GRKAVVEGAQ
PPWQQRLLTA EPSQLQPWSE EKHNPSNTWP LKCERRKVAG RASSPRLGEL GEEPPGRASN
AECSTIKAAS SGPKAEDLSH SLGPSSSQPA TSKGPCQHLS LGSVLSLELP KDLGLLRNVQ
DSIKIAWKEV AERKKGQQPC GVIQWEVKGP ELEVNNASLS KEMLSHQLTT CPRPGGSIEP
SRKALKSEHS TWFEEVSFNP GYDRQKTQSV AAASSREDGQ SLQVQGSSSG DFLDFQVHQL
SRISMLREQA GQEWNQLTAM LGKPGSPGRV QPEKPVDLKP QVREATRVEL RPSPTKLSSG
ALVRGEPPRE STKLKEVTLE SKLEAAPVSK ASEESPVRLP GGGTDPFPLI NLDLRATPQL
SVLEYDLSYP QQSLASASAG PQDLASAGHM MGLGLSKEAK PPGSVEVCHP DHELFEKDEE
ELQAIWSSVG GHSRQSPRAD PSMCPTMGNG SDEVQNPDVS NRKLILTSEN NVLVAKFMLP
ASAQLLCNPQ TGRGTGEGHK TEGSPSGFWA SLPSQEGHHG VKEVVSLGSV EGTGPQNRQK
HQEEDRDLGK TPHSKMEFQM MEGALERKHV LQTGGRKANY RTWSLFHTVL MRQTLCFYQD
RKDTLKSSVV ALPLNLSGAR CTQDMEYTKK TNCFRLHLRD GSEYLLRAPS QPLMNEWVSK
LQQNSGFPEV DYFQAAVQPA EGTSSPISSH LQGHHQPVTA KSQEITLLPR SSARMHLPFG
NREDLQDSAA SLAGDSQRAN SQMTGHRRFQ WSPTGSPRSR DANYQEEDYA LVTNKRRSYS
FTSATYQKIT PVSVPKEPLE PGSSYSITLY IGEQAMPRAR CHSFVATPGS PREVLGERGQ
GPPPRPKNKS VFKKFFGKKE
//
