ID A0A151P635_ALLMI Unreviewed; 616 AA.
AC A0A151P635;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 4 isoform B {ECO:0000313|EMBL:KYO44473.1};
GN Name=ENTPD4 {ECO:0000313|EMBL:KYO44473.1};
GN ORFNames=Y1Q_0016771 {ECO:0000313|EMBL:KYO44473.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO44473.1};
RN [1] {ECO:0000313|EMBL:KYO44473.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO44473.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO44473.1}.
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DR EMBL; AKHW03000764; KYO44473.1; -; Genomic_DNA.
DR RefSeq; XP_019338008.1; XM_019482463.1.
DR AlphaFoldDB; A0A151P635; -.
DR STRING; 8496.A0A151P635; -.
DR CTD; 9583; -.
DR OrthoDB; 180318at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF29; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 4; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833, ECO:0000313|EMBL:KYO44473.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 222
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 274..278
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 616 AA; 70556 MW; 98B31B61EB0F08B5 CRC64;
MGRISISCLF PASWHFSISP VGCPRILNTT LRQIVVIGIL TAAVSLLYYS LVVIRNKYGR
AYRDKKFHRY LARVTDTEAT DISNPNLNYG IVVDCGSSGS RIFVYCWPRH NGNPHDLLDI
KQMRDKDRKP VVMKIKPGIS EFANSPEKVS DYISPLLSFA AEHVPWAKHK ETPLYILCTA
GMRILPESQQ KAILDDLLTD IPVRFDFLFS DSHAEVISGK QEGVYAWIGI NFVLGRFEHI
DDEDDAVVEV HIPGSENKEA IIRKRTVGIL DMGGVSTQIA YEVPKTVSFA SSQQEEVAKN
LLAEFNLGCD AHQTEHVYRV YVATFLGFGG NAARQRYEDS IFTNTVFRNK LLGKQTSMTS
ESPYLDPCLP LDAEDKIQQN GQTLYLRGTG NFNLCREIIQ PFMNKTNETQ TSLNGVYQPA
VHFQNSEFYG FSEFYYCTED VLRMGGDYSA ARFIKAAKDY CATKWSVLRE RFDRGLYASH
ADLHRLKYQC FKSAWMYEVF HSGFSFPVNY SNLKTALQVY DKEVQWTLGA ILYRTRFLPL
RDIQQETFRG NHSHWRSFSF VYNHYLFFAC FLIVLLSILL YVLRLRRIHW RMLRNGSSAS
LWIEEGLPPQ KIPGAL
//
