ID A0A151P7A4_ALLMI Unreviewed; 4284 AA.
AC A0A151P7A4;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Cytoplasmic dynein 2 heavy chain 1 {ECO:0000256|ARBA:ARBA00023902};
GN ORFNames=Y1Q_0023013 {ECO:0000313|EMBL:KYO44952.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO44952.1};
RN [1] {ECO:0000313|EMBL:KYO44952.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO44952.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO44952.1}.
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DR EMBL; AKHW03000640; KYO44952.1; -; Genomic_DNA.
DR STRING; 8496.A0A151P7A4; -.
DR eggNOG; KOG3595; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR049400; DYNC2H1_AAA_dom.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF22; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF21264; DYNC2H1_AAA_dom; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 1636..1782
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1923..2078
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2235..2383
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 2892..2929
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3055..3145
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4284 AA; 489598 MW; C2277FC17F2C8174 CRC64;
MALPDDRRRR FLAATAANFF GLEPGAAAAS LGASEPLARF LDDGGEFLLA LRPAGACLAA
SNQVEAGDSK DKVLVFFKLR PQVITEDNLH SNIFVSSMLD SPITTLYQAV RQVFAPVLLK
DEKWSKEFDP KLQNLLSELE AGLGTVLRRS DPHYQGTKFS EDDVRAILTP SDEFQFWIER
AHRGSKLCSK ERASHFRDLF ETIAKDYYNL DSLSLYEAVD LVETTRDTVD DVWRQTEYDP
YPQPRMQNLL DVIGGSLENL KTGIMICEQW VAACHHLTGQ LWQHYAPHPW KNDKFSPEAL
DKLQKRLDEV LTIRTLYEKL TYFLPTGEQK ALLHLAQVFE PFAGLNPVHY NPYTEPLWKA
AVSQYERIIA PAEQKIASKL KAFISDIQDS PQQLLQAFQK YKELVKRPSI SKELLFERET
LLARLQDSIK DFCTDFEARC HGVPGDISGP LSGKNLSEVV NNIVWVRQLE LKVDDAIRIS
EALLSDLSGF RSFRRNADNL LEQLKLYEQD QFDDWSRDIQ TTLSDPRSGL CIQASSPVME
LDHSDGSLKI HYSDRLVTLL REVRQLAALG FIIPAKIQQV ANTAQKFCKQ AVILKQVAHF
YNSIDQQMIQ SQKPMMLQSA LAFEQIIKHS KVGSGEKTQI TWDNPKELEA YIQKLQTAAE
RLSTENRKLR KWHTSFIEKV IALMNIDLLR HQQHWKDGLQ ELRSGFTSAE MQGVHSCDMK
AWRQHWNHQL YKALEHQYQM GLEALNENLT EINIDLTFKQ GRLQFRPPFE EVRARYYREM
KRFISIPNQF RGVSETEEES IFAVMTERNA SGFLTTFSKA EDLFRRLGEV SNQFKEWVVF
GQVDMEILVE KHLSSEQDWE KNFKALKVRG KEAERLPSTI KIDCLIVNCN PVKTVIDDFI
QKLYDVLVLS LRKSIQAHLH DVSSFLTDAM EALIVRPHSV EELAEDNLKY KKLQEKKEEI
FLRFQEAEGK NKLLRTVAGG GLDTMSNLRA TWDKFELMME SHQLMIKDQI EVMKGDVMAH
VNVYLQELEK FKARWDQLKP SDDVIETGHR DMLEKSAQII KEKKTEFDEL EVTKNKLIED
CHHFEIEEPD FSLAKTVCKD IESCAEVWTL YEEFHQGFQE KAKEDWITFR SKTYLFEEFL
FNWHDKLRKM EEHTIMTVKL QKEVDKYKMT LPVLKYVRGE HLSPDHWLDL FRLLGLPRGT
SLENLLFGDL LKVADVIVEK AAELKDLNGR AQDYEDSQGR TIVLIKDWKD IVNQVGDNRC
LLQSLKDSPY YKGFEDKVSI WEKKLAELDE YLQNLNQIQR KWVYLEPIFG RGALPKEQAR
FNRVDEDFRS IMLDIKRDNR ITSLNARAGI RNTLMTILDQ LQRCQKSLNE FLEEKRSAFP
RFYFIGDDDL LEILGQSTNP LVIQSHLKKL FAGINSVNFD EEFKHIIAMK SLEGEIVPLK
NKILLSNDVE VWLNNLALEM KETLKQLLFD CVTAGRSSQC SIDPSLFPSQ ILSLAEQIQF
TEDVENAIKE HNLQQIELEL MAKLEHYTSI DTSMEDPGSR ESGILELKLK ALILDIIHNL
DVVKQLNEVQ VHSVDDWAWK KQLRFYMKDK KCYVQMVDAE LQYTYEYQGN SPKLVYTPLT
DKCYLTLTQA MKIGLGGNPY GPAGTGKTES VKALGGLLGR QVLIFNCDEG IDVKSMGRIF
VGLVKCGAWG CFDEFNRLEE AVLSAVSMQI QTIQHALKKH SPVCELLGKE VEMDHNSGIF
ITMNPAGKGY GGRQKLPDNL KQLFRPVAMT RPDNELIAEV ILYSEGFKDA KTLGRKLVAI
FNLARELLTP QQHYDWGLRA LKTALRGCGN LLHHLKRNGI KEIINESHIV VQALRLNTMS
KLTFADCAQF DALVKDVFPG IDFKDVEYAE LATGLQQVFK EANMEIINTQ IKKALELYEQ
LRQRMGVVIV GPSGAGKSTL WRMLRSALGK IGKVVKQYTM NPKAMPRHQL LGHIDMDTRE
WSDGVLTNSA RQVVREPQDI NSWIICDGDI DPEWIESLNS VLDDNRLLTM PSGERIQFGP
NVNFIFETHD LSCASPATIS RMGMIFLSDE DTDLHSLLKS WLRNQPEECR HNLENWIGDY
FEKALNWVLK QNDYVVETSL VGTVMNGLSH LHGCTDRGQF IISLMRGLGG NLNMKSRQEF
TKEIFNWARE SPPDPRKPLD TYYDPDTGHL MTYQLKKTEN LIADDFSNLQ TLPVIQTPDM
QRSLDYFRPW LNFDNKQPFL LVGPEGCGKG MLLRYAFSQL RSTQIATVHC SAQTTSQHLL
QKLSQTCMVI STNTGRVYRP KDCERLVLYL KDINLPKPDK WGTSTLVSFL QQVLTYQGFY
DENLEWVGLE NIQIVASMSA GGTLGRHKLT SRFTSIVRLC AIDYPERDQL QTIYSGYLEP
VLHKNLKNHS IWGSLPKIHQ LAGSMVQVYE QVRAKFTVDD HSHYLFTPCI LTQWVLGLFR
YDLAGGSSTH TIDYVLEIVA YEACRLFRDK IVGAKELHVF DNILMKVFQG DWGSDILHNM
TDIFYVTWGA SSEAFIAPGT TLPPHGRPLG RLNSADLKNV IKKGIIHYGR DNKEIEILLF
SEVLEYMSRI DRVLSFPGGS LLLAGRSGVG RRTATSLVSH MHGAVLITPK ISRGYEVKQL
KNDLKHVMEL AGIEAQQVVL LLEDYQFVHS TFLEMINSLL SSGEIPGLYT IEELEPLLSP
LKDQASQDGF TGPIFNYFTY RIQQNLHVVL IMDSSNLNFT INCESNPALH KKCQVLWMES
WSESSMKKIP EMLFTDSDEQ QKTDRAHIEP KKICSGDSDF FKSFLPIHES CKTYGATPSR
YMTFLRMYST INSSKRAELI KRQNHLQAGV SKLNEAKALV DELNRKAGEQ SVLLKTKQDE
ADAALQEITV SMQNASEQKT EMEKIKHKIA EEAAEIEERK RQIDDELKEV QPLVNEAKLA
VGNIKPESLS EIRSLRVPPD IIRDILEGVL RLMGIFDTSW VSMKSFLAKR GVREDIATFD
ARYIPKEIRE SVEELLSKNK ASFDPKNAKR ASAAAAPLAA WVKANVKYSY VLERIQPLEK
EQAGLQANLK KTEDRKQKLE DLLNSVGQKV SELKDKFQSR TTEAAKLEAE LAKAQKTLKA
AEVLINQLDR EHKRWNIQVA EITDELSTLP KRAQLAAAFI TYLSAAPEDQ RKASLDEWTK
SAGLEKFDLR RFLCTESEEL IWKSEGLPSD DLSIENALVI LQSQICPFLI DPSSRATEWL
KTHLKELRLE VINQQDTNII TVLELAVRFG KTLIIQEMDG VEPVLYPLLR KDLVAQGPRY
AVEIGDKMID YNEEFRLFLS TRNPNPLIPP DAASIVTEIN FTTTRSGLRG QLLALTIQHE
KPDLEEQKTK LLQHEEDKKI QLAKLEESLL ETLATSQGNI LENKDLIESL NQTKASSALI
QESLSESHRL QSFLDQERDA YLPLAESASK MYFIISDLSK INNMYRFSLA AFLRLFQRAL
QNKQESESTE ERIKSLISSL THMVYEYVCR CLFKADQLMF ALHFVRGMHP ELFQDNEWDT
FTGVIIGDTL RKSDSQRNIR DQIPSWIEQE RAWAVASLKI SFPALYQTLS FEDADLWRTF
SQSSVCEQDF PTCIAKKISL FQQVLVVQAV RPDRLQSAMA LFACRTVGIK ELSPPPLNLK
RLYKETLEIE PILIIISPGA DPSQELQELA SVERNAECYH QVAMGQGQAD LAIQTLKECA
RNGEWLCLKN LHLVVSWLPK LEKELNSLQP KPDFRLWLTA EVHPHFTPNL LQSSLKIAYE
APPGLKKNLM RTYESWTPEQ ISKKGNLSRA HALFSLAWFH AVCQERRNYI PQGWTKFYEF
SLSDLRAGYD IIDRLFDGAK HFQWEFVHGL FENAIYGGRI DNYFDMRVLR SYLEQLFNST
IIGGSHLRGK KMTRFPCSIS LPNSCSILDY RDTIESLPED DKPDFFGLPA NIARSSQRMI
SSQVISQLRI LSRSVTAGCK FDREIWSSEL SPVLNLWKKL NQNSNLIHQK VSPPSERQGS
PILSFIILEQ YNAILLVQSV HQSLAALSKV IRGTSLLSSE VQRLASALLN QKCPLAWQNK
WEGPEDPLQY LRGLVSRALA IQNWVDKAEK QTLLSDTLDL SELFHPDTFL NALRQETARV
MGFSVDSLKF TASWKGRIQE AKLQVKISGL QLEGCSFDGN RLSENQHDSP SVSSVLPCYM
AWIAQDAYGP YSPEECISLP VYTSAERDRV MTNIDVPCGQ NQDQWIQSGA ALFLKNQFLS
SDIEGPPQRV DLNNLENIRY LAAC
//
