ID A0A151PB91_ALLMI Unreviewed; 215 AA.
AC A0A151PB91;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Cystatin kininogen-type domain-containing protein {ECO:0000259|PROSITE:PS51647};
GN ORFNames=Y1Q_0018110 {ECO:0000313|EMBL:KYO46387.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO46387.1};
RN [1] {ECO:0000313|EMBL:KYO46387.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO46387.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000256|ARBA:ARBA00004239}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO46387.1}.
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DR EMBL; AKHW03000505; KYO46387.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151PB91; -.
DR STRING; 8496.A0A151PB91; -.
DR eggNOG; ENOG502RYAC; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR CDD; cd00042; CY; 2.
DR Gene3D; 3.10.450.10; -; 2.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR027358; Kininogen-type_cystatin_dom.
DR InterPro; IPR018073; Prot_inh_cystat_CS.
DR PANTHER; PTHR13814; FETUIN; 1.
DR PANTHER; PTHR13814:SF12; KININOGEN-1; 1.
DR Pfam; PF00031; Cystatin; 2.
DR SMART; SM00043; CY; 2.
DR SUPFAM; SSF54403; Cystatin/monellin; 2.
DR PROSITE; PS00287; CYSTATIN; 1.
DR PROSITE; PS51647; CYSTATIN_KININOGEN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Vasoactive {ECO:0000256|ARBA:ARBA00022858};
KW Vasodilator {ECO:0000256|ARBA:ARBA00022429}.
FT DOMAIN 30..132
FT /note="Cystatin kininogen-type"
FT /evidence="ECO:0000259|PROSITE:PS51647"
SQ SEQUENCE 215 AA; 24014 MW; 2B8EF584A1D4F98A CRC64;
MLMLGGEFKT SIDYELSTHV CAGCKHPIGS DSPDLLPILK LAVQNFNKRS ERHFLYALGE
IIKATSQVVA GINYEVEYKI KETNCSKHEY QDLHAECKPI FGVLEGRCEA KAFVDLSNTI
ASITEKCMFP DPPVCAGCPV PIPVDSPELE EVLKVSMEKY NSESNSDFYF KIRSVFHATV
QQDTLIKILT DETHIQGKNA HLIGKETKRI SLYAA
//
