ID A0A151PD99_ALLMI Unreviewed; 567 AA.
AC A0A151PD99;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=5'-AMP-activated protein kinase subunit gamma-2 {ECO:0000313|EMBL:KYO46960.1};
GN Name=PRKAG2 {ECO:0000313|EMBL:KYO46960.1};
GN ORFNames=Y1Q_0014519 {ECO:0000313|EMBL:KYO46960.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO46960.1};
RN [1] {ECO:0000313|EMBL:KYO46960.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO46960.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBUNIT: AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1
CC or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic
CC subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.
CC {ECO:0000256|ARBA:ARBA00025878}.
CC -!- SIMILARITY: Belongs to the 5'-AMP-activated protein kinase gamma
CC subunit family. {ECO:0000256|ARBA:ARBA00006750}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO46960.1}.
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DR EMBL; AKHW03000487; KYO46960.1; -; Genomic_DNA.
DR RefSeq; XP_014464480.1; XM_014608994.2.
DR AlphaFoldDB; A0A151PD99; -.
DR STRING; 8496.A0A151PD99; -.
DR GeneID; 102566003; -.
DR KEGG; amj:102566003; -.
DR CTD; 51422; -.
DR eggNOG; KOG1764; Eukaryota.
DR OrthoDB; 880743at2759; -.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04618; CBS_euAMPK_gamma-like_repeat1; 1.
DR CDD; cd04641; CBS_euAMPK_gamma-like_repeat2; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR PANTHER; PTHR13780:SF122; 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-2; 1.
DR PANTHER; PTHR13780; AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT; 1.
DR Pfam; PF00571; CBS; 3.
DR SMART; SM00116; CBS; 4.
DR SUPFAM; SSF54631; CBS-domain pair; 2.
DR PROSITE; PS51371; CBS; 4.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Kinase {ECO:0000313|EMBL:KYO46960.1};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Transferase {ECO:0000313|EMBL:KYO46960.1}.
FT DOMAIN 273..333
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 355..415
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 428..490
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 502..560
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 1..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 567 AA; 62272 MW; 93F88C463514C207 CRC64;
MGSAAMDPAG KEAAGAGGRK GPGHKKRALR VHIPDLSSFA MPFLDGDVES SDKNASRKVE
ESSNAGSPSK GLFSKGLQNR PSSPVSAPVR SKHSPGSPKT VFPFPYQESP PRSPRRMSFS
GIFRSSSKES SPSSNPSTSP GGIKFFSRSR KTSGLSSSPS TPTQVTKQPA FLLESYKHEP
ERLEARIHCS PPDTGQRFSL PPPQSAAKPP TVTPTLCATS KIAAAAAAAP PQPAAAPEGM
LEKLELDEEA LEESESDIYV RFMRSHKCYD IVPTSSKLVV FDTTLQVKKA FFALVANGVR
AAPLWESKKQ SFVGMLTITD FINILHRYYK SPMVQIYELE EHKIETWREL YLQETFKPLV
NISPDASLFD AVYSLIKNKI HRLPVIDPVS GNALYILTHK RILKFLQLFV SEMPKPAFMK
KNLDELGIGT YHNIAFIHPD TPIIKALNIF VDRRISALPV VDESGKVVDI YSKFDVINLA
AEKTYNNLDI TVTQALQHRS QYFEGVVKCS MLETLETIVD RIVKAEVHRL VVVNEADSIV
GIISLSDILQ ALVLTPAGAK QKESEAE
//
