ID A0A151PES3_ALLMI Unreviewed; 1348 AA.
AC A0A151PES3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Hepatocyte growth factor receptor {ECO:0000256|ARBA:ARBA00019839};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
DE AltName: Full=HGF/SF receptor {ECO:0000256|ARBA:ARBA00033136};
DE AltName: Full=Proto-oncogene c-Met {ECO:0000256|ARBA:ARBA00033117};
DE AltName: Full=Scatter factor receptor {ECO:0000256|ARBA:ARBA00030820};
DE AltName: Full=Tyrosine-protein kinase Met {ECO:0000256|ARBA:ARBA00033031};
GN ORFNames=Y1Q_0019695 {ECO:0000313|EMBL:KYO47586.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO47586.1};
RN [1] {ECO:0000313|EMBL:KYO47586.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO47586.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO47586.1}.
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DR EMBL; AKHW03000416; KYO47586.1; -; Genomic_DNA.
DR STRING; 8496.A0A151PES3; -.
DR eggNOG; KOG1095; Eukaryota.
DR eggNOG; KOG3610; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd05058; PTKc_Met_Ron; 1.
DR CDD; cd11278; Sema_MET; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016244; Tyr_kinase_HGF/MSP_rcpt.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625:SF61; HEPATOCYTE GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 3.
DR PIRSF; PIRSF000617; TyrPK_HGF-R; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000617-
KW 2};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR000617-3};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00023137};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRSR:PIRSR000617-2}; Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 898..921
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..481
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 1045..1312
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 1171
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-1"
FT BINDING 1051..1059
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2"
FT BINDING 1077
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 1124..1127
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2"
FT BINDING 1175
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2"
FT MOD_RES 1201
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT MOD_RES 1202
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT MOD_RES 1316
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT MOD_RES 1323
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT DISULFID 63..66
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 98..106
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 138..141
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 264..329
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 486..504
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 492..527
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 495..511
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 507..517
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
SQ SEQUENCE 1348 AA; 151524 MW; 7DD0053073E4EA73 CRC64;
MNMSAKYHLP NFIAETPIQN IILYDHHIYI GAVNKIYVLN ETLHNISVYK TGPVLENPDC
APCEDCKDKA NLSSSIWKDN VNMALLLETY YDDQLISCGS VSRGICHRHI IHLDNPADIE
SEVHCMYSKQ MDGESYNCPD CVVSTLGTKV LVTEKDRFVN FFVGNTMKSS FQPQHTLHSV
SVRRLKETQD GFEFLTDQSY IDVLPQYRDS YPIKYVHAFE NDHFVYFLTV QRESLDSQAF
HTRIIRFCSL DSELRSYMEM PLECIFTEKR RKRSIRREIF NILQAAYVSK PGAALAHEMG
LGVNDDILYG VFAQSKPDSS EPTNRSAVCA VSVKTINEFF NKIVDKQNMK CLQHFYGKDS
KYCLNRIFSR NASYCRTRDD EYRVEVTTPL QRVDLFMGQF NSILLTSISV FTKGNLTVAN
LGTSEGRFMQ IVISRSELTA PYVSFRLDSH PVSPQVIIEH SLVADGSTLV VTGRKITKIP
LNGPGCDHFK SCSQCLSAPT FMQCGWCSDQ CVRPQECVKG VWTQETCLPR VYEIFPNSAP
LEGGTRLTLC GWDFGFSRNN RLNLKHTEIL IGGKLCTLEE KASNKNKLEC SVAAANSTSL
NISSSVSSGH GTSLFNTFSY VNPVITHISP TYGPKSGGTL LTVAGKYLNT GKNRRILIGG
KQCTLKRVSD SIVECYTPAQ KIPSEYPVKM EIDLAIRKTK DHFTYREDPI VLKIHPTKSF
LSGGSTITAH GINLNSVCFP QMVITVPKLG KNFTVACNHR SNSEIICCTT PSLKSFNLQL
PFVTKVFFIF DGVTPLYFDF DYVNNPVFKH FEKPVVISRG SQNVIEIKGS YIDSEAVNGE
VLKVGNKSCE NIFSQSESVF CTVPSELLKT NSELNIEWKQ EVLSTVIGKV LVQQDPDYTG
LTVGVVSISI VLLLFVGLFL WMKKKKQIKD LGGDLVRYDG RVHTPHLDRL VSARSVSPTT
EMVSSESVDY RSTFLEDQFP SLSQNGSCRP IQYPHTDLSP ILSSGDSDLA SPLLQTNVHI
DISALNPDLV KEVEHVVIGA DSLIVHFNEV IGRGHFGCVY HGTLLDNDSR KIHCAVKSLN
RITDLEEVAQ FLKEGIIMKD FSHPNVLSLL GICLPNEGSP LVVLPYMKHG DLRNFIRNET
HNPTVKDLIG FGLQVAKGMK YLASKKFVHR DLAARNCMLD EKFTVKVADF GLARDVYDKE
YYSVHNKTGA KLPVKWMALE SLQTQKFTTK SDVWSFGVLL WELMTRGAPP YPDVNSFDIT
VYLLQGRRLL QPEYCPDPLY EVMLKCWHPK PELRPAFSEL VSKISTIFST FIGEHYVHVN
ATYVNVKCIA PYPSLLSSQD NIDRDVDT
//
