ID A0A151PFA5_ALLMI Unreviewed; 3805 AA.
AC A0A151PFA5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Ankyrin-2 isoform A {ECO:0000313|EMBL:KYO47455.1};
GN Name=ANK2 {ECO:0000313|EMBL:KYO47455.1};
GN ORFNames=Y1Q_0001248 {ECO:0000313|EMBL:KYO47455.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO47455.1};
RN [1] {ECO:0000313|EMBL:KYO47455.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO47455.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO47455.1}.
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DR EMBL; AKHW03000422; KYO47455.1; -; Genomic_DNA.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08804; Death_ank2; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 5.
DR Pfam; PF13637; Ank_4; 4.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 78..110
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 111..143
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 144..176
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 239..271
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 272..304
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 305..337
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 338..370
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 371..403
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 404..436
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 437..469
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 470..502
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 503..535
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 536..568
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 569..601
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 602..634
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 635..667
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 668..700
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 701..733
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 734..766
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 767..799
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 975..1130
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1132..1278
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 3358..3442
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1431..1459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1648..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1754..1914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1931..1956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2020..2102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2120..2384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2401..2425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2449..2658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2693..2755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2839..2877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2909..3007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3045..3249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3338..3358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3477..3503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3537..3677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3780..3805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1435..1449
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1671..1696
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1832..1847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1875..1889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1890..1907
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1931..1946
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2061..2075
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2155..2189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2192..2214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2312..2359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2401..2419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2450..2464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2489..2504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2514..2534
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2555..2572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2624..2646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2699..2715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2716..2732
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2737..2751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2842..2873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2956..2978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3093..3112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3114..3128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3167..3220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3222..3249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3477..3501
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3537..3572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3576..3591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3640..3664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3805 AA; 420356 MW; 3C89F0E1879E703D CRC64;
MAHAAASIKK VREAELDERE RNLEKERKKQ RKIPRERVDR KRKSDSNASF LRAARAGNLD
KVVEYLKSGI DINTCNQNGL NALHLAAKEG HVGLVQALLE KGSSVNSATK KGNTALHIAS
LAGQAEVVKV LLKEGATINA QSQNGFTPLY MAAQENHIEV VKYLLENGAN QSTATEDGFT
PLAVALQQGH NQAVAILLEN DTKGKVRLPA LHIAARKDDT KSAALLLQND HNADVQSKSG
FTPLHIAAHY GNVNVATLLL NRGAAVDFTA RNGITPLHVA SKRGNTNMVK LLLDRGGQID
AKTRDGLTPL HCAARSGHDQ VVELLLERGA PLLARTKNGL SPLHMAAQGD HVECVKHLLQ
HKAPVDDVTL DYLTALHVAA HCGHYRVTKL LLDKRANPNA RALNGFTPLH IACKKNRIKV
MELLVKYGAS IQAITESGLT PIHVAAFMGH LNIVLLLLQN GASPDVTNIR GETALHMAAR
AGQVEVVRCL LRNGALVDAR AREEQTPLHI ASRLGKTEIV QLLLQHMAHP DAATTNGYTP
LHISAREGQV DVASVLLEAG ALHSLATKKG FTPLHVAAKY GSLDVAKLLL QRRASPDSAG
KNGLTPLHVA AHYDNQKVAL LLLEKGASPH ATAKNGYTPL HIAAKKNQMQ IATTLLSYGA
ETNILTKQGV TPLHLASQEG HADMVTLLLE KGSNIHLATK TGLTSLHLAA QEDKVNVADI
LTKQGANQDA QTKLGYTPLI VACHYGNIKM VNFLLKQGAN VNAKTKNGYT PLHQAAQQGH
THIINVLLQH GAKPNAITTN GNTALAIARR LGYISVVDTL KVVTEEITTT TTTVTEKHKL
NVPETMTEVL DVSDEEGDDT MTGDGGEYLR PEDLKELGDD SLPSSQFLDG MNYLRYSLEG
GRSDSLRSFS SDRSHTLSHA SYLRDSAMID DTVVIPSQQV TNLAKEAERN SYRLSWGTEN
LDNVALSSSP IHSGFLVSFM VDARGGAMRG CRHNGLRIII PPRKCTAPTR VTCRLVKRHR
LATMPPMVEG EGLASRLIEV GPSGAQFLGP VIVEIPHFAA LRGKERELVI LRSENGDSWK
EHFCEYTEDE LNEILNGMDE VLDTPEELEK KRICRIITRD FPQYFAVVSR IKQDSNLIGP
EGGVLSSTVV PQVQAVFPEG ALTKRIRVGL QAQPMHHELV KKILGNKATF SPIVTLEPRR
RKFHKPITMT IPVPKASSDG MMNGYGGDTP TLRLLCSITG GTTPAQWEDI TGTTPLTFVN
ECVSFTTNVS ARFWLIDCRQ IQESVTFASQ VYREIICVPY MAKFVVFAKS HDPIEARLRC
FCMTDDKVDK TLEQQENFAE VARSRDVEVL EGKPIYVDCF GNLVPLTKSG QHHIFSFYAF
KENRLPLFVK VRDTTQEPCG RLSFMKEPKS TRGLVHQAIC NLNIMLPVYT KESESDQEQE
EEADVTSEKN DDETESTETS ILKSHLVNEV PVLASPDLLS EVSEMKQDLI KMTAILTTDP
TDKSGSIKVK DLGKTTEEEP GEPFEIVERV KEDLEKVNEI LRGGTYGGEE HVPQKSPLRR
EVVEEEWVIV SNEEIEEARQ NAPLEVTEPV CIEVRIDKGT TKEEKKDMTG MIDYLTDDLK
TLVSLHDVQP QILQEDLTGE RFEAVVLSRG SEKEEQDYPT AETQGAQEQH KPGLEIKKPV
RRKLKEKQKQ KEGDTQTTEE QSGLTKFSSE ESLDEEPGLM PAAVPEVSAV SPVIEETPIG
SIKDKVKALQ KRVEDEQKIR SKLPVRIQTK GSTTAERPTK RPVQAKKTVH KAQPPVSPSA
KTERLEETMS VRELMKAFQS GQDPSKNISG LFEHKSLKEK QRPPGKEPTQ REAVGLKSKI
AQVHKTDRSD RQPARKSQAS TGLKDSQSKK EAQASLRDVK KGEQVKAQSC KTAEPLSPVF
VEEESVKDAT LVKEKATDEQ GDTDFQISPD RKTSTDFSDV IKEELEDNDK YQQFRHLSVT
EEGELHLEQV LTSPFSIAFP SEHVKDGFLP ALSLQSAAFD GSSESLKHEG VADSPGSLLE
GTPQISSEES YKHEGLAETP ETSPESLSFS PKKTNEQIGE ARETTTAHKT AEVCSPKELS
SAEDDKVIAE KHLAAVTEAI TSLSDQSSEK LVPTASEKEA GKFADSSSAS IMKDVKSDQE
AEDTEHTHLT QSLEGHDTTV EREKDATSEP LSVVVRSPQS LELSLPSRDS ESFSPVADES
LAISHKDSLE ASPVLEDNSS HKTPDSLEPS PMKESPCRDS LESSPVEPRV KAGILTGQAP
VQPVLGKGET CPELASIRSR ILREPEGSTE DDGLEQTSLM ESSGKSPLSP ETPSSEEISY
EITPKTADSQ AQSSISKPVI IPEVSEEPED DPESEPKKRV TPEEEMFKMV TKIKMFDELE
QEAKQKRDYK KDSKQDEYFP VPDSDAACEA EVLEPTTLEG KGIPAVLTSS LEARKSSSSS
ESEPELTQLK KEAESGLFLE PTIRMQPPSP LPSSIDSSSS PEEAGFQPID PKQHAFRMGE
DQEELDKTTE ENSCKVTTEK SNFFHPDADI IAETAESTGY STEESETISP NGPVTHLDDA
LYHAITDETK KEVQVPQPSQ QDDTTEKDKD LTATGAVSEK SGDDPCGHTT SQYSVSQDSD
LTAADSPTHT ALGRDLEKAG KDCEAFQQDF YSKELPTEYS SLTNEKNEFE GCTADTHEDS
APHITSPYEN VSSEHFFTSS ERDARSTEAE KSMVEKVLSG SSLSGHASGC EDQSSEEVYM
EIESKHMDIF EKMPSGTSAS DPTTLDPSAL QNIRDEAEKL ISQVVITKTD VDCDEWSEIR
EDDEAFEARV KEEEQKVFGL MVDRQSQGTT PDTTPARTPT EEGTPTSEQN PFLFQEGKLF
EMTRSGAIDM TKRNYADESF HFFQVGQQLQ DEVSLSEEMK QAAQVESPKV ERSPDSFPPS
ESNETDPREE NAFTAESPVS EPSDKSEEMI STGTTKADLK SRIPIKMGIS ASSKSPKKET
AAFESSEDEC MFRVETDQID SSQVPCPISP EQSVVDVQLD FSTVTRSIYS EQDDESPDSS
PEEQRSVIEI PTAVMETVPS ESKSKIPVRA TAAVSQPFQQ SEQESPHSDG FIDSLQLETK
DDQSKPKSKI PIKATVQRAE QQYAYTETSF YKPESPKAPE MTDYQPTKQD NRSKSESDAS
VPMDPKIKRS IKARSYAEAD AETRERESEM KLELEIDEAT TGRTKVFSSR LPVKSRSATG
ASRSAVSPTS ENREQFFDLY KNSIEFFEEI SDEASKLVER LTQSEREQEL VSDDESSSAL
EVSVIENVPS IETQQSVPED IFDTRPIWDE SIETQIERIP DENVHDHAQD QQDDQERTEE
RLAHIADHLG FSWTELAREL DFTEEQIHQI RIENPNSLQD QSHALLKYWL DRDGKHATDT
SLTQCLTKIN RMDIVHLMET SSLDSLQIHG ARTYAEIEQT IGLDHSEGFS ALQEELYSSR
HKEDKEHSFS KDSDPSDHPP IVSEEDVSVS YSSFHEGTPK TEADLSISEL LRQAQKEHLQ
TEFSGKPQDL PEETSATQQE YFVTTPGTEQ SIPTKAGKEE VIEKSKGSTA APEEHKTPYF
HTPSSSERGD SPIVQEPEDI QLHQEQSPRR TSLVIVESTD EQPEKFERYY EDESLEKADE
IPEMPPETVT EEQYTDEHGH IVMKKVTRKI IRRYVSPDGT EKEEVIMQGA PQEPVTVKEG
DGYSKVVKRV VLKSDSEQSE VTFSEPTVLS SASEFQSEPV EGRKVSKVVK TTLVQGERME
KHLGDASLAT DLPSAKEDFE EDNNE
//
