ID A0A151PG19_ALLMI Unreviewed; 3360 AA.
AC A0A151PG19;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=CUB and sushi domain-containing protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Y1Q_0001859 {ECO:0000313|EMBL:KYO48031.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO48031.1};
RN [1] {ECO:0000313|EMBL:KYO48031.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO48031.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO48031.1}.
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DR EMBL; AKHW03000257; KYO48031.1; -; Genomic_DNA.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 27.
DR CDD; cd00041; CUB; 13.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 27.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 13.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656:SF4; PROTEIN BETA CHAIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR Pfam; PF00431; CUB; 12.
DR Pfam; PF00084; Sushi; 27.
DR SMART; SM00032; CCP; 27.
DR SMART; SM00042; CUB; 12.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 27.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 13.
DR PROSITE; PS01180; CUB; 12.
DR PROSITE; PS50923; SUSHI; 27.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3265..3286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 79..140
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 143..254
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 257..314
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 316..424
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 427..488
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 490..598
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 603..660
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 662..772
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 775..834
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 836..944
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 947..1007
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1009..1118
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1121..1181
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1183..1291
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1294..1355
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1357..1465
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1471..1532
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1534..1642
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1645..1704
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1706..1814
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1817..1876
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1878..1985
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1988..2049
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2051..2162
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2162..2224
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2225..2286
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2287..2351
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2352..2409
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2410..2467
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2468..2525
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2562..2624
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2625..2682
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2686..2743
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2744..2802
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2803..2862
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2863..2920
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2921..2978
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2982..3040
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3041..3100
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 285..312
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 631..658
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1009..1036
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 2380..2407
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2438..2465
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2496..2523
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2595..2622
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2653..2680
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2714..2741
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2773..2800
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2891..2918
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2949..2976
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3011..3038
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 3360 AA; 366006 MW; 3FC914923D003CC0 CRC64;
MLIIRFTGMN LPAPVISSKN WLRLHFTSDG NHRQKGFSAQ YQVKKQIELK SRGVKLMPSK
DNNQKTSVLT QVGVSQGHNM CPDPGIPERG KRIGNDFRLG SSIQFTCNEG YDLQGSKSIT
CKRVSDMIAA WSDQRPVCRA RMCDTYLRGP SGVITSPNYP VQYDNNAYCV WVITALNPAK
VIKLTFEEFE LERGYDTLTV GDGGEVGDQK TVLYVLTGST VPDLIVSTHH QMWLLFQTDS
VSNLLGFKAT YEEIDQGSCG DPGVPAYGKR EGSTFRHGDT LKFECQPAFE LKGQKTITCQ
KSSQWSAQKP VCVFSCFFNF TTPAGIVLSP NYPEEYGSSL HCVWLIIAKP ESRIHLAFND
FDVEPQFDFL AVKDGGTAES PVLGTFSGNQ IPSSLTSSGH VARLEFQTDH SMEKRGFNIT
FTTFRHNECP DPGVPVNGKR FGDSLQLGSS VSFLCDEGFI RTHGSETITC ILKEGNVVWN
NAVLRCEAPC GGHLTSPSGM ILSPGWPGFY KDSLNCVWVI EAQPGYPIKI TFDRFKTEVN
YDTLEVRDGR SYSSPLIGVY DGTQVPQFLI STSNYLYLLF TTDKSHSDIG FQIRYETVKL
QSDHCLDPGI PVNGQRHGND FYVGALVTFS CDSGYTLSDN EALECEPNFQ WSRPLPSCEA
LCGGYIRGSS GTILSPGFPD FYPNNLNCTW TIETSHGKGV FFTFHTFHLE NGHDYLLITE
NGSFTQPLKQ LTGSRLPAPL SAGLFGNFSA QIRFISDFSM SYEGFNITFS EYDLEPCDEP
EVPAYSIRKG LQFGVGDVLT FSCFPGYRLE GVSRITCLGG RRRVWSSPLP RCVAECGSSV
TGTQGVLLSP NYPINYNNNH ECIYSIQTQP GKGIQLKART FELEAGDVLK VYDGSNNSAR
LLGSFSRSEM LGTSINSTSS SMWLEFITNS ENTSKGFELQ FSSFELIKCE DPGIPQFGYK
VHDEGHFAGS SVSFNCDPGY TLRGSRALVC LTGERRAWDQ PLPVCVAECG GTIRGDSSGR
ILSPGYPTPY DHNLNCIWTV EAEAGCTIGL HFIVFHTEEF HDVLRIWDGP VENGILLKEI
SGSSLPNDVH STFNSVILQF NTDFFTSKQG FAIQFSVSTA TSCNDPGIPQ NGTRSGDSKE
AGDSIVFQCD PGYALQGEAK ITCVEIENRF FWQPDPPSCI APCGGILTGP SGVILSPQYP
EPYPPGKECD WKLTVSPDYV IALVFHTFNL EPGYDFLHIY DGPDSLSPLI GSFYGSQLPE
RIESSSNSLF LAFRSDASVS NAGFIIDYTE NPRESCFDPG LIKNGTRVGT DLKLGSTITY
YCDGGYEIEG VSTLTCIMGG DGKPVWNKPR PTCTAPCGGQ YTGSDGVVLS PNYPQNYTSG
QVCLYFVVVP KDYVVFGQFA FFQTALNDVI EVHDGPNQHA RLLSSLSGSH TGESLPLATT
NQILIKFSAK GQATAKGFHF VYQAVPRTSA TQCSSVPEPR YGRRIGSDFS VGAIVRFECS
AGYALQGSRS IECLTMPGAL AQWNVSVPTC VVPCGGNLTE RKGTILSPGF PEPYLNSLNC
VWKITVPEGA GIQIQVISFV TEQNWDSLEV FDGGDNTATM LGSFSGTTVP ALLNSTSNQL
YLHFYSDISV SAAGFHLEYK TVGLSSCPEP AVPGNGLKIG ERYLVNDVVS FQCEPGYALQ
GHSHISCMPG TVRRWNYPPP LCIAQCGGTA EEMEGVLLSP GFPGNYPSNM DCSWRISLPV
GFGAHVQFLN FSTEPNHDFV EIRNGPYDTS NVIGRFSGTE IPGSLLSTSH ETTVYFHSDH
SQNKPGFKLE YQAYELQECP DPEPFANGVV RGAGYNVGQS ISFECLPGYQ LIGHPVLTCQ
HGTNRNWDHP LPRCEVPCGG NITTQNGTVY SPGFPNQYPN SQDCTWILTV PVGYGIHLNF
TLLQTEPYND FITVWDGPQQ TAPQLGVFTG NSAKKSTQSS SNQILMKFHS DAANGGIFAI
YFYAYQLSRC HPPTIVPNAE IITANEEFNI GDIVRYRCLP GFTLVGNEIL TCKLGTHLQF
EGPPPTCEVH CPMNEVLTDS TGVILSQSFL GSYPHFQTCS WVVKVEPGYN ISLIIEYFLS
EKQYDEFEIF DGPSGQSALL LSLSGNYSAP LMVTSTGNRV YLRWSSDHAY NRKGFKIRYS
APYCSLPPPP LHGSILSQAG MQPGSTIRFG CDAGYRLVGH SIATCLRHPQ GYYHWNGAIP
LCQAVSCGVP RPPKNGIVFG KEYTVGTQAV YHCNQGFHLQ AGDESTTECL PTGQWSNGNT
PPPCVAVTCP DINSIAVEHG RWRLTYEIQY QYNAQLMLIC DPGYYYTGQR VIKCQANGTW
SIGDPMPTCK IISCGDLPTP PNGNKIGTLT DYGATAIFSC NTGYTLVGSR VRECMANGLW
SGAEVKCLAG HCGLPDPIVN GQINGENYNY RGSVVYQCNP GFRLIGMSVR ICQQDHHWSG
KTPVCVPITC GHPGNPANGL TQGTQFNLND VAKFVCNTGY HLEGSSQSQC LANGQWSNSL
PTCRTPDSGP VPPLMLMSAA PSMPTLCQDL GIGRTPPIDT VVNCTDPGHL ENSIRQVQPS
GPHRFSFGTT VSYQCSHGYY LLGTHVLTCQ GDGTWDRPLP QCLLVSCGHP GSPPHAQISG
DKYTVGSVVR YSCLGKRTLT GNSTRMCQLD GRWSGSLPHC SGGSQGVCGD PGIPSHGIGL
GDEFGVDSMV RFSCEPGYTL RGSSERICQA NGSWSGTQPE CEVISCGNPG TPSNARVMFN
DGLVFSSSII YQCREGYYST GVLSRHCTVN GTWTGTTPEC TVINCGDPGV PANGIRLGND
FTYNKTVVFQ CTPGYMMESD RASSLTCTKD RTWNGTKPVC KAIICKSPQA LPNGKVVGSD
FSWGSSVSYA CLEGYQLSLP AVLTCEGNGT WSGEIPQCFP VFCGDPGIPA QGRREDRGFT
YRSSVSFSCL APLVLVGSAR RFCQSDGMWS GTQPSCIDPT LTTCVDPGVP LFGMQNNSQG
YQVGSVIFFK CQKGYLLQGS TTRTCLPNLT WSGAQPDCVP HHCKQPETPS HANVGALDLP
SLGYTLIYSC QSGFYLTGGS EHRTCKADGS WTGKPPICLA DIRPSGRPVG TARDPPLAKV
SVPADVFAKN SLWKGSYEYM GKKQSAMLTV TSFDPATSKV NATLIDHSGV KLQVSGIYKR
EDVHLLLQVY QITGPVENFV NKFKNDKWAL DGHVSSESSS GTFVYQGFVR GEGFGQFGLQ
RFDISMIEND PESIGHHFAS NSSSVAAAIL VPFIALIIAG FVLYLYKHRR RPKVPFNGYA
GHENTNVRAT FENPITCPFA RIVQGQVSCC RSCVTSLVFI HDLPSPNPGC GEAAAPLLDC
//
