ID A0A151PHE0_ALLMI Unreviewed; 1124 AA.
AC A0A151PHE0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=RAS protein activator like-3 {ECO:0000313|EMBL:KYO48372.1};
GN Name=RASAL3 {ECO:0000313|EMBL:KYO48372.1};
GN ORFNames=Y1Q_0017133 {ECO:0000313|EMBL:KYO48372.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO48372.1};
RN [1] {ECO:0000313|EMBL:KYO48372.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO48372.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO48372.1}.
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DR EMBL; AKHW03000209; KYO48372.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151PHE0; -.
DR STRING; 8496.A0A151PHE0; -.
DR eggNOG; KOG3508; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR PANTHER; PTHR10194:SF96; RAS PROTEIN ACTIVATOR LIKE-3; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 370..489
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 547..739
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 981..1085
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 9..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 909..944
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1124 AA; 125563 MW; 61411E17E8F8C1F0 CRC64;
MGTRRQPSAA ERKPSRELRS QEVTARRREA KMEVEKPPPT AESPSLLKSY KWRMGPQGGE
KELERALPTP GPSRWSKLHT WKRAYSHPET DTPEESTARS GQSPGPPGPT GSSRAAARRS
MFQRAFSAPA KAPKEPRGQE GGKLNLRKYL RSMSHRRSPE NGAKAERTPL EVAREAPRPV
QRIPLTPSPE VPVWDVSNFS LMDGQLVLAA RDEEVLFRSR SRTGSSISDT HVQHPLGGRR
EPDLSSEGRG SPGPRAPGRG TESDTSTNSQ FGNVKGLLWK RLKERKGRVV AKADAPTTPP
ADSDRLPSRH GSHESLLPPP TVAELDLSGD DVVIRPLHGS LLGEKFCFQI INAEGSRCFG
CTSVAERDRW IENLRRTVQP NKDNCERVEN TLSLWVYEAR DLPPKRRYLC QLHLDGTLYA
RTTAKAVGPS GTLFWGEHFA LDTLPPAREL RVSVLREDEG RRRDSAPLGI ITVPLAELAT
SRQPLERWYS LAGPAKDRGP MPGLRLRGRY QEIQVLPIVR YKEFAEYITF HYRELCARLE
PAIPVRHKEE LASALVHVLQ STGKAKEFLI DLGVAELDRF DDREALIFRE NTLATKAIDE
YMKLVGARYL LDMLGEAVAQ LYQSEDCCEV DPSKCAPQDL SDNQNNLRQA CEEVFQRITA
SCDAFPAELN EIFAAWQEEC QERAKDGIGQ RLISASLFLR FLCPAIMSPS LFGLIQEYPS
DTTARTLTLV AKVIQNLANF TTFGEKEAYM GFMNEFLEQN WSSMTSFLQS VANPDSSAHL
DTYDGYVDLA LELATLHLLL CDIFSSLDQR TQKQLEPLPT ILDAIQKGTP VPVSIHLNPS
RPAAEKPGFV PPRELSKHSP LIKSPSLSSI QKGRGQEEEA TVLLRPPRDR HHVQRTQSVP
AQSKATRRPR KQSSLEHVAE SVKEESRKGS PCHGPQDNRS HSGRSKLRQS ASLPRKSTVP
WQRYSGEAAK AQTELYTMRP LEKHGKQIEE LQKELAEARE TLGRFESQMA VLAAQNEVLR
EEQAELRMQE EQLRNQLEEA AAHLASLSAR VTSAEGSRKK DLEKLKASEE KTKGLERRLS
AMERKQAELC SALLGHALKQ PHVLLQPGPC GETQNGDEAH VTSV
//
