ID A0A151PI60_ALLMI Unreviewed; 1104 AA.
AC A0A151PI60;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN Name=MSH3 {ECO:0000313|EMBL:KYO48642.1};
GN ORFNames=Y1Q_0004043 {ECO:0000313|EMBL:KYO48642.1};
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO48642.1};
RN [1] {ECO:0000313|EMBL:KYO48642.1, ECO:0000313|Proteomes:UP000050525}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO48642.1};
RX PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y., Gongora J.,
RA Dalzell P., Moran C., Bed'hom B., Abzhanov A., Burgess S.C., Cooksey A.M.,
RA Castoe T.A., Crawford N.G., Densmore L.D., Drew J.C., Edwards S.V.,
RA Faircloth B.C., Fujita M.K., Greenwold M.J., Hoffmann F.G., Howard J.M.,
RA Iguchi T., Janes D.E., Khan S.Y., Kohno S., de Koning A.J., Lance S.L.,
RA McCarthy F.M., McCormack J.E., Merchant M.E., Peterson D.G., Pollock D.D.,
RA Pourmand N., Raney B.J., Roessler K.A., Sanford J.R., Sawyer R.H.,
RA Schmidt C.J., Triplett E.W., Tuberville T.D., Venegas-Anaya M.,
RA Howard J.T., Jarvis E.D., Guillette L.J.Jr., Glenn T.C., Green R.E.,
RA Ray D.A.;
RT "Sequencing three crocodilian genomes to illuminate the evolution of
RT archosaurs and amniotes.";
RL Genome Biol. 13:415-415(2012).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KYO48642.1}.
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DR EMBL; AKHW03000179; KYO48642.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151PI60; -.
DR STRING; 8496.A0A151PI60; -.
DR eggNOG; KOG0218; Eukaryota.
DR Proteomes; UP000050525; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000050525}.
FT DOMAIN 932..948
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..58
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1104 AA; 124608 MW; 0FAC6C627A3A7133 CRC64;
MRRGQRPGQA VLSRFFRPAA TQSGQEPPGG GSSESDGKKR RAPPNNELSK KRSKSIQKNS
EEGGSSVKIL DVEEPKKCDG SRLCLKTLDK LREFSSDSGQ SHTRSQVLSF QGSQSAGLEK
CPSIAERTLE TNSSLHSEET GSQISQKEEP CFDLNQFSAS RKSYEKPQNT SDTNINKRTK
TVYTPLELQV IELKKQYKDA ILCVECGYKY RFFGEDAEIA AKELNIFCHL DHNFMTASIP
TFRLFVHVRR LVAKGHKVGV VKQTETAALK AVGENKSSLF SRKLTALYTK STLIGEDIFF
GLITLLVETN LDDPADVEEI TSDVTDNYLL CICENEENSR EKKKGDAVIG IVAIQPTTGE
VVFDSFQDSA SRLELESRVL RLQPVELLLP SNLSDQSERL LKSLTSLSLH DDRIRIERMQ
NIHFEYSHAF QLITDFYARE VLDITGSQKL SVILNLAKPV ICSLAAIITY LKEFNLEKIL
NNPSNFKQLS SEAEYMKLNA TTLKNLEILQ NQTDLKTKGS LFWVLDHTKT CFGRRKLKKW
VTQPLMKSSE INARLDAVSE ILLSESSVFG QIQNHLCKMP DVERGLCSIY HKKCSTQEFF
LIVSTLSRVE AEIEALVPAI RSHVKAPLLQ NALLEIPELL HPMKKYLKIL NEEAAKTGDK
TQLFKDLTDF PTIRKRKEEI QDVLSQIQLH LQEIRRLIKN ASADYVTVSG QEFLIEFKNS
LISSVPSDWV KVSSTKAVSR FHTPFIIENY RHLNQLREQL VLDCSAEWLI FLDSFSEHYH
SMAKAVDHLA AVDCIFSLAK MAKQGDYCRP IVQDKRREII IKNGRHPVID VLLGEQDQYV
PNSTNLSGDG ENVMIITGPN MGGKSSYIKQ VALITVMAQI GSYVPAEESA VGIVDGIFTR
MGAADNIYKG RSTFMEELTD TAEIIRKATS RSLVILDELG RGTSTHDGIA IAHATLEYFI
RDVESLTLFV THYPSVCELE KIYPSNVGNY HMAFLVNEEE SEQKGSEDEE NPEFITFLYQ
ITRGVAARSY GLNVAKLADV PDEILKTAAR KSKELEGLVN MKRKRLKYFA EIWNINDSQE
LQKWKKICET EDDRLFLISH ILLN
//
