ID A0A151RA12_CAJCA Unreviewed; 659 AA.
AC A0A151RA12;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=phosphoribosylglycinamide formyltransferase 1 {ECO:0000256|ARBA:ARBA00012254};
DE EC=2.1.2.2 {ECO:0000256|ARBA:ARBA00012254};
GN ORFNames=KK1_039378 {ECO:0000313|EMBL:KYP39329.1};
OS Cajanus cajan (Pigeon pea) (Cajanus indicus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Cajanus.
OX NCBI_TaxID=3821 {ECO:0000313|EMBL:KYP39329.1, ECO:0000313|Proteomes:UP000075243};
RN [1] {ECO:0000313|EMBL:KYP39329.1, ECO:0000313|Proteomes:UP000075243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Asha {ECO:0000313|Proteomes:UP000075243};
RX PubMed=22057054; DOI=10.1038/nbt.2022;
RA Varshney R.K., Chen W., Li Y., Bharti A.K., Saxena R.K., Schlueter J.A.,
RA Donoghue M.T., Azam S., Fan G., Whaley A.M., Farmer A.D., Sheridan J.,
RA Iwata A., Tuteja R., Penmetsa R.V., Wu W., Upadhyaya H.D., Yang S.P.,
RA Shah T., Saxena K.B., Michael T., McCombie W.R., Yang B., Zhang G.,
RA Yang H., Wang J., Spillane C., Cook D.R., May G.D., Xu X., Jackson S.A.;
RT "Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop
RT of resource-poor farmers.";
RL Nat. Biotechnol. 30:83-89(2012).
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-
CC formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-
CC ribosyl)glycinamide (10-formyl THF route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00005054}.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000256|ARBA:ARBA00004575}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004575}; Nucleoplasmic side
CC {ECO:0000256|ARBA:ARBA00004575}.
CC -!- SIMILARITY: Belongs to the NEMP family.
CC {ECO:0000256|ARBA:ARBA00005748}.
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DR EMBL; KQ483917; KYP39329.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151RA12; -.
DR STRING; 3821.A0A151RA12; -.
DR UniPathway; UPA00074; UER00126.
DR Proteomes; UP000075243; Unassembled WGS sequence.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004644; F:phosphoribosylglycinamide formyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd08645; FMT_core_GART; 1.
DR Gene3D; 3.40.50.170; Formyl transferase, N-terminal domain; 1.
DR HAMAP; MF_01930; PurN; 1.
DR InterPro; IPR002376; Formyl_transf_N.
DR InterPro; IPR036477; Formyl_transf_N_sf.
DR InterPro; IPR004607; GART.
DR InterPro; IPR001555; GART_AS.
DR InterPro; IPR019358; NEMP_fam.
DR NCBIfam; TIGR00639; PurN; 1.
DR PANTHER; PTHR31587:SF3; EXPRESSED PROTEIN; 1.
DR PANTHER; PTHR31587; TRANSMEMBRANE PROTEIN (DUF2215); 1.
DR Pfam; PF00551; Formyl_trans_N; 1.
DR Pfam; PF10225; NEMP; 1.
DR SUPFAM; SSF53328; Formyltransferase; 1.
DR PROSITE; PS00373; GART; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW Reference proteome {ECO:0000313|Proteomes:UP000075243};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 340..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 87..269
FT /note="Formyl transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00551"
FT REGION 526..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 659 AA; 72745 MW; 02E5490BFAAE5AE9 CRC64;
MEAQQILPRF CPKSSLAPSV PLVKQSFSLM CPPLPSSSSY PSVQSGAFPA ISIVRREVCS
SSWRRVWCSS SSGAEPKEGH EVTVRRKKLA VFVSGGGSNF RSIHEASKRG SLHGDVLVLV
TNKSECGGAE YARNNGIPVI LFPKAKDESN GLSPADLVDT LRKFEVDFIL LAGYLKLIPA
ELIRAYQKSI LNIHPSLLPA FGGKGYYGMK VHKAVIASGA RFSGPTIHFV DEHYDTGRIL
AQRLVPVLAN DTAEELATRV LNEAKSAISR LSSHTYSWDP SPLPFFSSSL SNHHDPLTLK
GVGIENPVVE VTPSSTPLEH IILWFPWSSI DLMGKTLCRF ILDCIGIFLV IIIILFQGMK
LMPIGRKNIL YLIIYGSVVG AGSFLLHQFS LILNSIFQSL GLSEEMHNSA GAALGYWIVR
RFFISKEDGS VDAGAAQFVK WAMYIVGTTS ILQSTLDPLL AIPLPAIGAL IYCGAACKLF
SAIKLFHGCL YKVLGSRLIV AFGNDDYLLQ RLRRRRGRAE FLSKSTPKGK QWKSPKGKLW
NSPKKSAWSD SPVRGVVLPY SGILSQSSGT QIGQDYYSTF HKTRNRKQFT KQEWDEFTRE
STKQALAEWA ASPEFTDWIV EHANRIKVLP RESSDETMGS ESDSTDLGSG NGYRLFNWQ
//
