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Database: UniProt
Entry: A0A151RCP4_CAJCA
LinkDB: A0A151RCP4_CAJCA
Original site: A0A151RCP4_CAJCA 
ID   A0A151RCP4_CAJCA        Unreviewed;       720 AA.
AC   A0A151RCP4;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   28-FEB-2018, entry version 10.
DE   RecName: Full=Delta-1-pyrroline-5-carboxylate synthase {ECO:0000256|PIRNR:PIRNR036429};
DE   Includes:
DE     RecName: Full=Glutamate 5-kinase {ECO:0000256|PIRNR:PIRNR036429};
DE              Short=GK {ECO:0000256|PIRNR:PIRNR036429};
DE              EC=2.7.2.11 {ECO:0000256|PIRNR:PIRNR036429};
DE     AltName: Full=Gamma-glutamyl kinase {ECO:0000256|PIRNR:PIRNR036429};
DE   Includes:
DE     RecName: Full=Gamma-glutamyl phosphate reductase {ECO:0000256|PIRNR:PIRNR036429};
DE              Short=GPR {ECO:0000256|PIRNR:PIRNR036429};
DE              EC=1.2.1.41 {ECO:0000256|PIRNR:PIRNR036429};
DE     AltName: Full=Glutamate-5-semialdehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036429};
DE     AltName: Full=Glutamyl-gamma-semialdehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036429};
GN   ORFNames=KK1_038245 {ECO:0000313|EMBL:KYP40434.1};
OS   Cajanus cajan (Pigeon pea) (Cajanus indicus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae;
OC   Phaseoleae; Cajanus.
OX   NCBI_TaxID=3821 {ECO:0000313|EMBL:KYP40434.1, ECO:0000313|Proteomes:UP000075243};
RN   [1] {ECO:0000313|EMBL:KYP40434.1, ECO:0000313|Proteomes:UP000075243}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Asha {ECO:0000313|Proteomes:UP000075243};
RX   PubMed=22057054; DOI=10.1038/nbt.2022;
RA   Varshney R.K., Chen W., Li Y., Bharti A.K., Saxena R.K.,
RA   Schlueter J.A., Donoghue M.T., Azam S., Fan G., Whaley A.M.,
RA   Farmer A.D., Sheridan J., Iwata A., Tuteja R., Penmetsa R.V., Wu W.,
RA   Upadhyaya H.D., Yang S.P., Shah T., Saxena K.B., Michael T.,
RA   McCombie W.R., Yang B., Zhang G., Yang H., Wang J., Spillane C.,
RA   Cook D.R., May G.D., Xu X., Jackson S.A.;
RT   "Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume
RT   crop of resource-poor farmers.";
RL   Nat. Biotechnol. 30:83-89(2012).
CC   -!- FUNCTION: P5CS plays a key role in proline biosynthesis, leading
CC       to osmoregulation in plants. {ECO:0000256|PIRNR:PIRNR036429}.
CC   -!- CATALYTIC ACTIVITY: ATP + L-glutamate = ADP + L-glutamate 5-
CC       phosphate. {ECO:0000256|PIRNR:PIRNR036429}.
CC   -!- CATALYTIC ACTIVITY: L-glutamate 5-semialdehyde + phosphate +
CC       NADP(+) = L-glutamyl 5-phosphate + NADPH.
CC       {ECO:0000256|PIRNR:PIRNR036429}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       glutamate 5-semialdehyde from L-glutamate: step 1/2.
CC       {ECO:0000256|PIRNR:PIRNR036429}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       glutamate 5-semialdehyde from L-glutamate: step 2/2.
CC       {ECO:0000256|PIRNR:PIRNR036429}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the gamma-
CC       glutamyl phosphate reductase family.
CC       {ECO:0000256|PIRNR:PIRNR036429}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the glutamate 5-
CC       kinase family. {ECO:0000256|PIRNR:PIRNR036429}.
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DR   EMBL; KQ483836; KYP40434.1; -; Genomic_DNA.
DR   UniPathway; UPA00098; UER00359.
DR   Proteomes; UP000075243; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004349; F:glutamate 5-kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004350; F:glutamate-5-semialdehyde dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0055129; P:L-proline biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd07079; ALDH_F18-19_ProA-GPR; 1.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 2.
DR   HAMAP; MF_00412; ProA; 1.
DR   HAMAP; MF_00456; ProB; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR001057; Glu/AcGlu_kinase.
DR   InterPro; IPR005715; Glu_5kinase/COase_Synthase.
DR   InterPro; IPR019797; Glutamate_5-kinase_CS.
DR   InterPro; IPR000965; GPR_dom.
DR   InterPro; IPR005766; P5_carboxy_syn.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PIRSF; PIRSF036429; P5C_syn; 1.
DR   PRINTS; PR00474; GLU5KINASE.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   TIGRFAMs; TIGR01092; P5CS; 1.
DR   TIGRFAMs; TIGR00407; proA; 1.
DR   TIGRFAMs; TIGR01027; proB; 1.
DR   PROSITE; PS00902; GLUTAMATE_5_KINASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR036429};
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR036429};
KW   Complete proteome {ECO:0000313|Proteomes:UP000075243};
KW   Kinase {ECO:0000256|PIRNR:PIRNR036429};
KW   NADP {ECO:0000256|PIRNR:PIRNR036429};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR036429};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR036429};
KW   Proline biosynthesis {ECO:0000256|PIRNR:PIRNR036429};
KW   Reference proteome {ECO:0000313|Proteomes:UP000075243};
KW   Transferase {ECO:0000256|PIRNR:PIRNR036429}.
FT   DOMAIN       15    260       AA_kinase. {ECO:0000259|Pfam:PF00696}.
FT   DOMAIN      290    552       Aldedh. {ECO:0000259|Pfam:PF00171}.
SQ   SEQUENCE   720 AA;  78559 MW;  C1C275C960CEDACD CRC64;
     MEVLDPSRSF MRNVKRVIIK VGTAVVTREE GRLAVGRLGA LCEQIKQLNS LGYDIILVSS
     GAVGIGRQRL RYRKLINSSF ADLQKPQLEL DGKACAAVGQ NSLMALYDTL FTQLDVTSAQ
     LLVTDNDFRD KDFRKQLTET VKSLLALKVI PVFNENDAVS TRKAPYEDSS GIFWDNDSLS
     ALLALELKAD LLVLLSDVEG LYSGPPSDPH SKLIHTYIKE KHQNEITFGD KSRVGRGGMT
     AKVKAAVHAA EAGIPVVITS GFAAENIINV LQGQRIGTLF HKDAHEWVQV KEVDAREMAV
     AARECSRRLQ AISSEERKQI LLKIADALEA NENVIRTENE ADVAMAQEAG YEKSLVARLI
     ASLANNMRII ANMEDPIGQI LKRTELSDGL ILEKTSSPLG VLLIVFESRP DALVQIASLA
     IRSGNGLLLK GGKEAKRSNA ILHKVITEAI PDTVGGKLIG LVTTREEIPE LLKLDDVIDL
     VIPRGSNKLV SQIKSSTKIP VLGHADGICH VYVDKSANVE MARRIVLDAK IDYPAACNAM
     ETLLIHRDLI EKGWLNDIVV DLRNEGVILY GGPRASSLLN IPRAHSFHHE YSSLACTVEI
     VDDVYAAIDH INLYGRHVTV FFLIGNIAHT DSIIAEDKEV ANVFLRQVDS AAVFHNASTR
     FSDGARFGLG AEVGISTSRI HARGPVGVEG LLTTRWILKG GGQVVDGDRG IVYTHTDLAT
//
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