ID A0A151TG56_CAJCA Unreviewed; 659 AA.
AC A0A151TG56;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Long-chain-fatty-acid--CoA ligase {ECO:0000256|ARBA:ARBA00026121, ECO:0000256|RuleBase:RU369030};
DE EC=6.2.1.3 {ECO:0000256|ARBA:ARBA00026121, ECO:0000256|RuleBase:RU369030};
GN ORFNames=KK1_012312 {ECO:0000313|EMBL:KYP66032.1};
OS Cajanus cajan (Pigeon pea) (Cajanus indicus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Cajanus.
OX NCBI_TaxID=3821 {ECO:0000313|EMBL:KYP66032.1, ECO:0000313|Proteomes:UP000075243};
RN [1] {ECO:0000313|EMBL:KYP66032.1, ECO:0000313|Proteomes:UP000075243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Asha {ECO:0000313|Proteomes:UP000075243};
RX PubMed=22057054; DOI=10.1038/nbt.2022;
RA Varshney R.K., Chen W., Li Y., Bharti A.K., Saxena R.K., Schlueter J.A.,
RA Donoghue M.T., Azam S., Fan G., Whaley A.M., Farmer A.D., Sheridan J.,
RA Iwata A., Tuteja R., Penmetsa R.V., Wu W., Upadhyaya H.D., Yang S.P.,
RA Shah T., Saxena K.B., Michael T., McCombie W.R., Yang B., Zhang G.,
RA Yang H., Wang J., Spillane C., Cook D.R., May G.D., Xu X., Jackson S.A.;
RT "Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop
RT of resource-poor farmers.";
RL Nat. Biotechnol. 30:83-89(2012).
CC -!- FUNCTION: Catalyzes the conversion of long-chain fatty acids to their
CC active form acyl-CoAs for both synthesis of cellular lipids, and
CC degradation via beta-oxidation. {ECO:0000256|RuleBase:RU369030}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-
CC CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560,
CC ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3;
CC Evidence={ECO:0000256|RuleBase:RU369030};
CC -!- PATHWAY: Lipid metabolism; fatty acid metabolism.
CC {ECO:0000256|RuleBase:RU369030}.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432, ECO:0000256|RuleBase:RU369030}.
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DR EMBL; CM003608; KYP66032.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A151TG56; -.
DR STRING; 3821.A0A151TG56; -.
DR OMA; VICHTSG; -.
DR OrthoDB; 22305at2759; -.
DR UniPathway; UPA00199; -.
DR Proteomes; UP000075243; Chromosome 6.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004467; F:long-chain fatty acid-CoA ligase activity; IEA:InterPro.
DR CDD; cd05927; LC-FACS_euk; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR045311; LC-FACS_euk.
DR PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR PANTHER; PTHR43272:SF94; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU369030};
KW Fatty acid metabolism {ECO:0000256|RuleBase:RU369030};
KW Ligase {ECO:0000256|RuleBase:RU369030};
KW Lipid metabolism {ECO:0000256|RuleBase:RU369030};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU369030};
KW Reference proteome {ECO:0000313|Proteomes:UP000075243}.
FT DOMAIN 72..479
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 659 AA; 73925 MW; 95A0D8D8BE7C3D8E CRC64;
MAGVYTVKVE EARPATPEKP SAGPAYRCIF AKDALTNLPS LFESPWDFFR DTKTRCPSNP
MLGRRKKTGS KVDPYEWITY QEAYDAAIQI GSAMKSRGVN PGDRCGIYGS NCPEWIIAME
ACNGYAVTYV PLYDTLGPNA VEFIINHAEV SIAFVQDNKI PSVLSCLDRC SNLKTIVSFG
NVSSSQKKEA EELGASCFTW GEFLQLGNTD FDVPLKKKTN ICTIMYTSGT TGEPKGVIIK
NEAFMTQVLS IDQILYITDV VGTEDDVYFS FLPLAHIYDQ IMETYCIYKG SSIGFWQGDV
RFLMEDIQAL KPTLFCGVPR VYDRVYAGIS SQISSGGALR STLFQYAYNY KLGYLEKGLP
QDKAAPLFDR LVFDKIRQAL GGRVRLLLSG AAPLPRQVEE FLRVTFGANM SQGYGLTESC
GGCFTAISNV FSMMGTIGVP MTTIEARLES VPEMGYDALS SEARGEICLR GNTLFSGYHK
RQDLTEEVLV DGWFHTGDIG EWQPNGSMKI IDRKKNIFKL SQGEYVAVEN IENKYLQCPL
VTSIWVYGNS FEPFLVAVVV PERNALEDWA MKHNSNVDFK SLCGNLKARK YILDELNRTG
QKHQLRGFEM LKAVHLEPIP FDMERDLVTP TFKLKRSQLL KHYKDYIDQL YKEAKAQKV
//
