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Database: UniProt
Entry: A0A151WNX3_9HYME
LinkDB: A0A151WNX3_9HYME
Original site: A0A151WNX3_9HYME 
ID   A0A151WNX3_9HYME        Unreviewed;       836 AA.
AC   A0A151WNX3;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   22-FEB-2023, entry version 22.
DE   RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891, ECO:0000256|RuleBase:RU362092};
DE            EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891, ECO:0000256|RuleBase:RU362092};
GN   ORFNames=ALC60_11420 {ECO:0000313|EMBL:KYQ49491.1};
OS   Trachymyrmex zeteki.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmicinae; Trachymyrmex.
OX   NCBI_TaxID=64791 {ECO:0000313|EMBL:KYQ49491.1, ECO:0000313|Proteomes:UP000075809};
RN   [1] {ECO:0000313|EMBL:KYQ49491.1, ECO:0000313|Proteomes:UP000075809}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tzet28-1 {ECO:0000313|EMBL:KYQ49491.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KYQ49491.1};
RA   Nygaard S., Hu H., Boomsma J., Zhang G.;
RT   "Trachymyrmex zeteki WGS genome.";
RL   Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Introduces a single-strand break via transesterification at a
CC       target site in duplex DNA. Releases the supercoiling and torsional
CC       tension of DNA introduced during the DNA replication and transcription
CC       by transiently cleaving and rejoining one strand of the DNA duplex. The
CC       scissile phosphodiester is attacked by the catalytic tyrosine of the
CC       enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme
CC       intermediate and the expulsion of a 3'-OH DNA strand.
CC       {ECO:0000256|RuleBase:RU362092}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC         passage and rejoining.; EC=5.6.2.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000213,
CC         ECO:0000256|RuleBase:RU362092};
CC   -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC       {ECO:0000256|ARBA:ARBA00009446, ECO:0000256|RuleBase:RU362092}.
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DR   EMBL; KQ982905; KYQ49491.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A151WNX3; -.
DR   STRING; 64791.A0A151WNX3; -.
DR   Proteomes; UP000075809; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   CDD; cd00186; TOP1Ac; 1.
DR   CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR   Gene3D; 3.40.50.140; -; 1.
DR   Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR   Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR   Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR   InterPro; IPR000380; Topo_IA.
DR   InterPro; IPR003601; Topo_IA_2.
DR   InterPro; IPR023406; Topo_IA_AS.
DR   InterPro; IPR013497; Topo_IA_cen.
DR   InterPro; IPR013824; Topo_IA_cen_sub1.
DR   InterPro; IPR013825; Topo_IA_cen_sub2.
DR   InterPro; IPR013826; Topo_IA_cen_sub3.
DR   InterPro; IPR023405; Topo_IA_core_domain.
DR   InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR   InterPro; IPR006171; TOPRIM_domain.
DR   InterPro; IPR034144; TOPRIM_TopoIII.
DR   PANTHER; PTHR11390:SF20; DNA TOPOISOMERASE 3-BETA-1; 1.
DR   PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR   Pfam; PF01131; Topoisom_bac; 1.
DR   Pfam; PF01751; Toprim; 1.
DR   PRINTS; PR00417; PRTPISMRASEI.
DR   SMART; SM00437; TOP1Ac; 1.
DR   SMART; SM00436; TOP1Bc; 1.
DR   SMART; SM00493; TOPRIM; 1.
DR   SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR   PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR   PROSITE; PS50880; TOPRIM; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU362092};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362092};
KW   Reference proteome {ECO:0000313|Proteomes:UP000075809};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029,
KW   ECO:0000256|RuleBase:RU362092}.
FT   DOMAIN          3..148
FT                   /note="Toprim"
FT                   /evidence="ECO:0000259|PROSITE:PS50880"
FT   REGION          804..825
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   836 AA;  93831 MW;  D49420748E43BBA5 CRC64;
     MKTALMVAEK PSLAASLANI LSSGRCSTRK GLNGSCSVHE WVGQFRSETV NFKMTSVCGH
     VMTLDFIGKY NNWDKVDPAE LFSCSTEKKE AVPKLKIPYF LAKEGAHCDY LVLWLDCDKE
     GENICFEVDI WRARFSAITE KDIKSALANL IKPNENEAKS VDARQELDLR IGCAFTRYQT
     KFFQGKYGDL DVSLISYGPC QTPTLGFCVQ RHDEIQTFKP DPYWVLQVTV KSPDGQDIVL
     SWNRVRSFDK EVASMFLSHV KEHDQATVVS VQSTEKSKSR PIALNTVELM RVASSGLGMG
     PQHAMQIAER LYTQGYISYP RTETTSYPEN FDLLSTLKQQ QSNSEWGEEV RKIIAAGINR
     PKKGHDAGDH PPITPMKHAT RNELDGDLWR LYDYITRHFI ATLARDCRYL STTVKFEIGI
     EIFTVTGHSL LSPGYTSILT WQALGNSDTL PKFMSDEKVN IQEAKLVECY TQPPDYLTEA
     ELISLMEKHG IGTDASIPVH INNICIRNYV TVAAGRKLIP TSLGIVLVHG YQKIDPELVL
     PTMRSAVEEQ LNLIALGRAD FYAVLQHTVE IFKQKFHYFV QSIEAMDQLF EVSFSPLSAS
     GKAHSRCGKC RRYMKYIQTK PSRMHCAHCN ETYNLPQNGN IRIYKELKCP LDDFELLSWS
     TGTRGKSYTF CPYCYNNPPF RDMKKGMSGC NSCTHPTCPH GMNSNGLSSC LECDLGILVL
     DPSAAPKWKL GCNRCDVIIH LFENAHKVTV DTDTCDCGAQ LVTVEYKQDK SKLPNEATEM
     SGCVFCTPAF AALVEKHRAV ASKPVVTRGR GHAKSRNRGK PKPPKDKMAQ LAAYFV
//
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