ID A0A151X600_9HYME Unreviewed; 4735 AA.
AC A0A151X600;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=ALC60_05296 {ECO:0000313|EMBL:KYQ55797.1};
OS Trachymyrmex zeteki.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Trachymyrmex.
OX NCBI_TaxID=64791 {ECO:0000313|EMBL:KYQ55797.1, ECO:0000313|Proteomes:UP000075809};
RN [1] {ECO:0000313|EMBL:KYQ55797.1, ECO:0000313|Proteomes:UP000075809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tzet28-1 {ECO:0000313|EMBL:KYQ55797.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYQ55797.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Trachymyrmex zeteki WGS genome.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; KQ982490; KYQ55797.1; -; Genomic_DNA.
DR STRING; 64791.A0A151X600; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000075809; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR CDD; cd08664; APC10-HERC2; 1.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR006624; Beta-propeller_rpt_TECPR.
DR InterPro; IPR021097; CPH_domain.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR037976; HERC2_APC10.
DR InterPro; IPR010606; Mib_Herc2.
DR InterPro; IPR037252; Mib_Herc2_sf.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR PANTHER; PTHR22870:SF463; E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED; 1.
DR PANTHER; PTHR22870; REGULATOR OF CHROMOSOME CONDENSATION; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF11515; Cul7; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF06701; MIB_HERC2; 1.
DR Pfam; PF00415; RCC1; 16.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM01337; APC10; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00706; TECPR; 4.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF159034; Mib/herc2 domain-like; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 3.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS51416; MIB_HERC2; 1.
DR PROSITE; PS00626; RCC1_2; 2.
DR PROSITE; PS50012; RCC1_3; 19.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000075809};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 520..571
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 572..623
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 626..677
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 678..729
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 730..781
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 1876..1949
FT /note="MIB/HERC2"
FT /evidence="ECO:0000259|PROSITE:PS51416"
FT DOMAIN 2702..2879
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT REPEAT 2894..2945
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 2946..2999
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3000..3051
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3052..3103
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3106..3157
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3158..3209
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3210..3261
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3876..3927
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3928..3981
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 3982..4033
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4034..4085
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4088..4139
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4140..4191
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 4192..4243
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 4381..4708
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1352..1393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1585..1613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1940..1981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2510..2544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4716..4735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 4676
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 4735 AA; 519333 MW; DE3CFFA34B3F081F CRC64;
MSSQLNITVR PEVRLDAKWL KTDIQRFLYR DGLAELWNEM VRDGEIVGSF SDGLVNAAGI
VAKKGENGHY YCGMRVLSCL CCDGICGPQH GCNCTPCQKL DEEETARTTA IVEKSMSAKR
MMDSWVWGPQ PSLTDLKGCI DLSIKEQRKL CCEVANSTLS ATRLRQRLIV ARRYFTALSR
HKPQEIKDTS NLPKPRPNEK ATLGLARVGS RAALNFSFAY LRRAWRSGED VEFCSELLTE
SLEALQSLPE ATLFDESNVS QVWLEVVERS AKFLRQVVTG EVTTGRSWRP VPLSDQHTAL
CLLLELVAQR ATLSSLLDSV VLLLHLSGKN KNQDNRVTPP GSTAPLVPLL RRLNMIPATK
SRRHLDRNVT PGPCEVLLKY LRLPDDDAVS VDLRKAAVII MCNLSRLAAP LLPPASTEYG
FPRNGNGKQT FQEVLAWGGV KFGNGSTPFY CDAIAELGIK QLCCTERALM ILSLNGNVYN
MYHGSETQYP QRVHGFSDKP ITMIASHADG KHYLTLTQDG CVYSWGNGDG GRLGHGDTVS
YDEPKLIEAL LEKNIVFIAC GSTYSAALSA NGELYTWGRG NYGRLGHGNF DDVMTPILVT
TLKGHTVVHV ACGSGDSQTL CVTASGIVFS WGDGDYGKLG RGGTDGSKTP KIVDKLLDIN
VVKVFCGSQF SAALTAHGEV YTWGKGDAYR LGHGSEEHVR YPKVIESLRD RKVKDLSVGT
THILALTEDQ FVYGWGRNDY GQIDPTLGPI ISEPTLCPTL SSKTVIGLAS GPTQSFAWCM
SAWSGGASRV AFVVDICEET FQLLDTLLSK SCEGLPGIRP PTQDRECLAV ATLNLLRLQL
HTMLTHNIDT KSVGLATSSP LLNSLKQRCV NLASATGILA TIQEAAQVVL QTGWSILLPT
ANERAKTLSS FLPNTSNNVE QSSSANIYIN SGQRFMADLL VSSLMVDGGL ELALKAAIKV
EIADMPDEKD FLDVGTSNAV KVKIETRQGM KDGFNSGKNI TTISLLQLIQ QLIRNGTCIT
QSRLQQGSSQ QVDRNEHLRR FDNSPSLNLL LRFQRLLIAQ VYECITRQSR TEDLHDQEMM
GAESLLKKYI AQICDHATEI LPLAAEIGGR SVKDFISIAG VLKGDIINVL LPELVTCLIL
LQIDYSMLLI DMNWMDVIAP ILDSLDHFVK LAPTMEKNEA DDLSWPGIIA PLHGNKIPIQ
EEPSLIRWAD LENHNRDGGL WVVVNNNVYD VQDIRNDGSW SPYEVLQRYV VGRDETSTVT
QCGVPYSQLS PPRDMMDSCF VGHYCQAEPD ENARVTIEVT DVCSSLLDTE RALGFLLGLH
AYRMRQSLTL QSAEKEAGVW LTTNFLRGGL QVLQPPNPYE EEKDEARSNT STAANSPTEP
PLPVHAKNEQ QKEHEDRTIA FIHALAEAHK IDDGHVRAFL TLVDRYSKTN NLFSHADFCG
DHPVEEISRV LMAVIIKHLG LGQQALALAE QELKIVNSAR LSNQLADMVR AIYQTKWNLV
RIRQQQNRSY KEVCAPAQER CKFLLYEVRS ATSYEVKGLE DLKLLYTVPR FKRAARTVLA
DIHKNKDSSG GGGKPEDILN ASIQNAKTKN KPDGDTTSSS KEGLTATTSS STKLEDMSDI
KNKIMQMTEK IRCRPMQWAT ADYNGLMTNI IEFVINDGIG GDVETLRRAM YCQMQRARIR
EQGISMMREL LKKDYLIPSV KYSLLNGWLG LTYENKSLSD GITHCLYNIQ LTTPYQKSKV
ILAEAEVISW AVQALRTYVV QAELPNKQKV SGKSSLNQGT YTWLRKLPRA RFLLTILGML
TNHECANEIG LLINSGLLSS ILTLLRQIGP SSASFCENGE GQGQGGDGEA LKVKTEITAI
YEDALQKNKP PTVQLSGMEL AALMKVGTRV VRGADWKWGD QDGPPPGVGR VIGELGDDGW
IRVQWDNGAT NSYRMGKEGK YDLKLADPPT PPDDDSDETD SDTSLDGNKT ENSGFRGEDL
HPTTCLKSAS TNLLRIILLS CGVEADKVPA ISIKILTSTL HGIISTANRS SESITHVQLA
RQHHETWATF SLLRAIAKST DLCKSLSSQA WLNLFLGIVV DETKPCLEKQ IMITKLLAAV
LPSWGTETVL SNMMQFLEKS FGILGQVALT CDIAAISELH SNKCRMSLTA SYSSTVVEEL
TWLIRFLHSL PGWNEAVNKF LSTKLALTVD LWNESSLFHI QMNENGGENG LCIQRTVMAT
LVVIGGLDNR IRIGGLVNSD GEVGTVCKFT KHSKIVMQLW NGNGTRKIVS FHAAKRINEK
FQLERMPLTE SLISVWTNLF LGIACMDKRP GGMPVIAGAV NPTILRSQQQ QLAALNAGKA
MLAYQSKLRK ILKYSLINEI NDDERRTSTL LQEILLRATK PQPLKPIFKR RELEEAALAV
SQYLVSELRH TPIQRTGMTS DPTTPTSDCS LVSLTSSQRR HCKGNITAKK SSTAAPVSPL
VAVVVEMGFH KKSVELAIKS ISVADQGSVT AESVVGWLLE NPDAALSDTE TLSSLDGLTD
GSDDSISEDL DDSPSGQEGA INSGALPTYM KRSDFLSVDE YAIYVRDNVV PGMLVRCCKS
YEEVEYSDVG QVVKIDAENL HDLNAQVAWQ RKGGTYWVRF IHIELLGYPP SLPGPPPALK
VGDKVRVKAS VTLPKYNWGS VSHHSVGVVT AITNNGKNVS VDFPQQHGWT GCVAEMEKVP
SCHHFVTCHS CYLTPISESY LIDDWSKCIR TLSVSSRENW ATRLVDGSGK YWQSCGSQGK
HWIRLEMLSG ILIHSLKIIV NPQDSSYMPS VIAVNVGDSF TNLVELRTIT IRYSDTNVTL
LQDMKEYYPC IEIAIKQCRN GGIDCKIHGL RIMGRQNMFE NQLTTSVSFL ASDWEVLQEQ
VAIQRSVDTP PQQSAVYVWG LNDKDQLGGL KGSKIKLPVY SEILSKLKPI HIAGGSKTLF
IVSQEGKLYA CGEGTNGRLG LGDDNNMCEP KAIPFLSQFV IKKVAVHSGG KHALALTQDG
KVFSWGEGED GKLGHGNCIS LDKPKLIEAL KSKRIRDIAC GSGHSAAIAS NGELYTWGLG
EYGRLGHGDT IMQTRPKLIQ ALVGHRVVQV ACGSRDAQTM ALTTEGYVYS WGDGDFGKLG
RGGSDGCYTP LLVDRLNNLG VIQVECGAQF SLALTKYGEV WTWGKGDYFR LGHGNDHHVR
KPTLVEGLRG KKIIHVAVGA LHCLAVTDTG QVYAWGDNDH GQQGNGTTSV NRKPSLVHDL
EDARVNRVSC GSSHSIAWVL VDQPSNGNQD PVTFPTVRDP LGQMCLGLNN APEQNGTVTA
TNDTVATRPS LASIILSLES NVAKQQALQH VINALLIMQA RVAIVTALQS HSMLNGCAST
KHAPIVAATD VIPPSEGAMT SSTEHAVYQN VGDIAQGGGE APANVAEAVN VPTSPKLTPE
TEDYPLAMLA MSMSSSASLS SRASKMSTSA MSVIAATLTS NAQVVGEDGA TTSGLDEFTS
ALTEDDARVL VDLLKLAVAN RVCASAKETI SSVLIALGKV NGSIGSMLLE LCVTELEDTA
ANSNCVNNTP QPVVQETPHP YIDDTTLTGH VKIPGAEALR VEFDRLCSTE KRHDPLTIMD
GSGRVVAVRS GRDWIEWGPE IKIQGDELRW RFCSDGSVNG WGWKFTVYPI LAKTAPYELG
SDRAVLSQPT IALAEHLLMD NSLINSDKNV ASRLATALSQ CSQLSTLSAQ QRMWALRKLQ
VVYTNGPGIK PEVTLSSLLG SLPQALLRQY AYEDPMVRGG KQLMHSDFFK VLVALACDLE
LDGMQFCSEM HKWSWFRRYC LAARVAKSLV DRTPLPKAFC YEVTKQLNEM DAMDGNADCT
KDHESHNMFK QGHDEQLLQW LNRRPEDWTL SWDGSGAIYG WGHNHRGQLG GLEGPKVKLP
APCESLSALR PIQLAGGEQT LFAVTADGKI YSTGYGAAGR LGIGGTDSVM IPTLLESIQH
VFIKKVAVSS GGKHCIALSS EGHVYSWGEG DDGKLGHGNK VSYDRPKLIE DLLGVEIIDI
ACGGHHSAAI TSAGWLYTWG KGRYGRLGHG DSDDQLRPKV VEALQDYKVI DVACGSGDAQ
TLCVTDDDNV WSWGDGDYGK LGRGGSDGCK VPLKIDSLAG LGVVKVECGS QFSVALTRSG
AVYTWGKGDY HRLGHGTDDH VRRPRKVAAL QGKKIISIAT GSLHCVACSD KGEVFTWGDN
DEGQLGDGTT SALHRPRLVH ALQGKKITRV ACGSAHTLAW STAKATQSRM PASTPMEYDL
VKDLSYSVLR NRLVLLHHFA ELLCPALAMF PTTGHIGLSK LAPMLVYSIK EATFRKVIQA
TMVRDRQHGP VIELNRIQVK RARAKGGLAG PDGIKSVFGQ MVSKMSLLTQ DVLFLPHRVW
KVKFVGESVD DCGGGYSESI AEMCDELQNG SLPLFIPTPN GREDNGTNRD CFLLNPMADS
QLHMNMFQFL GILMGIAIRT GSPLSLNLAE PVWKQLAGIS LTPADLTEVD RDYVPGLLCI
RDMDPDEKVF QTLEMPFSTP SAAGHDMALS NRYLKITPEN RHEYVRLALD YRLHEFDTQV
AAVREGLSKV VPVPLLALFS GAELETMVCG SPDIPLNLLK SVATYKGIEA MAPLVQWFWE
VMDEFSNPER SLFLRFVWGR TRLPRTIADF RGRDFVLQVM DKYNPPDQFL PESYTCFFLL
KMPRYSCKAV LRQKLKYAIH FCKSIDTDEY ARVQAATNSD TEDTDSLTSE EHTSL
//
