ID A0A151XAH9_9HYME Unreviewed; 2325 AA.
AC A0A151XAH9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=ALC60_03810 {ECO:0000313|EMBL:KYQ57288.1};
OS Trachymyrmex zeteki.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Trachymyrmex.
OX NCBI_TaxID=64791 {ECO:0000313|EMBL:KYQ57288.1, ECO:0000313|Proteomes:UP000075809};
RN [1] {ECO:0000313|EMBL:KYQ57288.1, ECO:0000313|Proteomes:UP000075809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tzet28-1 {ECO:0000313|EMBL:KYQ57288.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KYQ57288.1};
RA Nygaard S., Hu H., Boomsma J., Zhang G.;
RT "Trachymyrmex zeteki WGS genome.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; KQ982351; KYQ57288.1; -; Genomic_DNA.
DR STRING; 64791.A0A151XAH9; -.
DR Proteomes; UP000075809; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 3.30.60.190; -; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KYQ57288.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000075809};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1760..1956
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 2030..2309
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 80..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2325 AA; 263820 MW; CEBF2CA74D78707E CRC64;
MHFSSRIRCS KRKRLYTCPR CGIGYCGAEC YKSDAHTDCS ESFYRQCVED ELKSQENDPA
ARQKMMEILK RVHEADMEND ILENNSDEGN TSGEDYPLDS DDEQELLDLE TRLKNVNLED
PNELWSVLSE AERQEFEALI KNGEVEKLLP KWVPWWTCRV EKKLIQLIEE DIKDVYSNLK
YPELIDVPLF NELQKASPCV LFNVTNVIYA YAYVALYYIG DYLNCAEEAT HVFLIICENI
RHNEVFKDVD SAIESVVDNV KNVDWLPQDE QTITALREAG ASISQGPGVE MKTVYTSAAL
SELHRRLKCK MMADERLFFS NAVQQLARCL AAIKPTPWEK VNKLYKLCPQ DSAQGVFRLD
QRSQDATIAL GIYFLESGLQ HRDKILPYLL RLLRGLSKAV WRDEVKCSLA ERVPVAERFS
FCLNTLLSDV AARCEPVREE IISTQVEILA VLTNLIRGYK DQNSNRGLQA KISLCKCLVP
VLIGLARSMG RFACTDPPLL CRIFPRRGTP SPVSSTENRL MPDKKQHSFS NFRPIIPRSL
SGNFNSCMDN AFPGYDSHDY NCGKRPSLQS FLSVPYDPTT YFFSRYGSSF NQFPQMRCNE
SPERRAGMQF TVVHLQSVLA LAKKLLTKEI LIFLDEEAQQ VYNSGQVHIF PYRTFSETMN
LVMVALLREL LQNQRDLPAP FTRDVQEFVK GLFLSGQTEL QSRQHDASER EDIDTNFRTV
NRFKVNVMAN SACVDLLVWA IGDETVSGEY DLSALFADIS SMLIGKGADS LCGRLVEKIN
SNHGPKLVLA HMPLLMVCLE GLGKLAQKFP NIASTSIYYL RDFLIAPSPI LLKLYRQHSE
YSMKEHQFKV LVQGKEISDS KQTSSVHTAF EKLRDAAIGN LCIALEAAHS VNPDCVPALV
ASVSNRLYTA DISDGESDEK LKNEVVSKNI VIMLGHVAVA LKDTPKTMRT IFPFFQQLFC
RTPSDLDFLI VDQLGCMIIA KCESKIYEGI MQMFSMSLGS STATYAASDD RKQYCHVSKA
VTNALANIAA NLQGESELDD LLLHLLELFV QLGLEGKRAS DKMPNSIVAT KTASSAGNLG
VLIPVIAILM RRLPPIRHPQ KRLLKLFKDF WLYCVIMGFA ADHSSRLWPS EWHEGVKEIA
VKSPYLISQT SARLEMRELQ YTSAVRNDSV SLNELQELRS QVLKISTRTN DISAYVTKLQ
FAQCTYLLSV YWSETLRVAN SSEPSLQPIM EYLCDTDLQK DKSGMWQCIC CVADSVFAKF
KDVMQRKPKD EQREKELENH AQFLLVRFNH VHKLIRRVAD KYLSALVDAF PHLLWNCKVL
WSMLDILQIL SYSLQLDPNE ETPSLRIPGT PYSIELMNTL EAREIIVKDF TARCKGIVQE
AMKWAPQATK SHLQEYINQI PSSGMRNHSG LSLAIDSVLE FVDTAIPTIV PANTNSLDKR
PRGPKGASSW LLSMMSTRSW HAGEVAGMLA LARTESPTAE MTLEECRNKV VERLIEAVRR
ACQDRDDTIH RGALWRATAL LISMPGIHRR LLHTVACSQI ELFTTAAMTT AVECWQWILT
VRPDLKLRFL QEMLLAWQYT VDKKMGLFTP NEQEVSPLAV YEGCKLGPNP PYVKPHDIWV
TFIVELVETA KYCCQETVDM IALLLHRSLP MTVGASGEEP GITRHVAAVG VRFKLLSCGL
VLLQGDVLPR TLSKNVLRER VYSNCLDYFC RERQLPTQEI DQLSEDIVTL IRFWQVMHSD
KKYLMMTGAD NEFEIVTSQT YTTAMIPSET IGSLAATLAP TPNDFSRSPS NVWMSTMPMS
TSTNTLSKRS NRSKRIINAN VLVKDYIKKR NLILESLAVE IEMLLVWRNP LVYIRVSPIQ
ALAFFSRQFP HHPISAQYAV HVLDSYPADA VLFYIPQLVQ AVRHDSMGYV IEFIKKIAKR
SQVVAHQLIW NMHTNVYMDE DKQMKDPVLY DILDLLTKNI LNALSGPAKQ FYEREFDFFE
KITNISGEIR PYPKGPERKA ACLDALAKVQ VQPGCYLPSN PEAMVIDIDY QSGTPMQSAA
KAPFLARFKV QKYGINELEN IALAVSTNGK VDSKRETEEQ TWQAAIFKVG DDVRQDMLAL
QVISIFKNVF QKVGLCGVIE CVPYATSRDQ LGRTTDSDMY QYFIAQHGDE TTKEFQNVRR
NFVKSMAAYS VITYLLQIKD RHNGNIMIDT QGHIIHIDFG FMFESSPGGN LGFEPDIKLT
DEMVLVMGGK MEAAPFRWFM ELCVQAFLAV RPYQEAIISL VSLMLDTGLP CFRGQTIKLL
RSRFVPTATD RDAAIFMINV IRNSYLNFRT KTYDMIQYYQ NQIPY
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