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Database: UniProt
Entry: A0A151ZRV5_9MYCE
LinkDB: A0A151ZRV5_9MYCE
Original site: A0A151ZRV5_9MYCE 
ID   A0A151ZRV5_9MYCE        Unreviewed;      1143 AA.
AC   A0A151ZRV5;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   05-JUN-2019, entry version 17.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=DLAC_03951 {ECO:0000313|EMBL:KYQ96665.1};
OS   Tieghemostelium lacteum.
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Dictyosteliales;
OC   Raperosteliaceae; Tieghemostelium.
OX   NCBI_TaxID=361077 {ECO:0000313|EMBL:KYQ96665.1, ECO:0000313|Proteomes:UP000076078};
RN   [1] {ECO:0000313|EMBL:KYQ96665.1, ECO:0000313|Proteomes:UP000076078}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TK {ECO:0000313|EMBL:KYQ96665.1,
RC   ECO:0000313|Proteomes:UP000076078};
RA   Gloeckner G., Schaap P.;
RT   "Dictyostelia acquired genes for synthesis and detection of signals
RT   that induce cell-type specialization by lateral gene transfer from
RT   prokaryotes.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYQ96665.1}.
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DR   EMBL; LODT01000021; KYQ96665.1; -; Genomic_DNA.
DR   EnsemblProtists; KYQ96665; KYQ96665; DLAC_03951.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000076078; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000076078};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076078};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      171    521       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      585   1013       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1051   1122       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1    101       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A151ZRV5}.
FT   COMPBIAS      1     22       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A151ZRV5}.
FT   COMPBIAS     35     64       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A151ZRV5}.
FT   COMPBIAS     69    101       Acidic. {ECO:0000256|MobiDB-lite:
FT                                A0A151ZRV5}.
SQ   SEQUENCE   1143 AA;  129766 MW;  011ECAE4DCADCA74 CRC64;
     MKRNLQLNLN NNSNNSNGGG TADKKLKLQP IVKPNSSIPK PSTSQTYQQP TSSTGGSSNT
     NRYRGGGGDD EEEEEEEDDD DEDDDDEEEE EEEGDVDEYE DIDIMDEDLS QDSSQQLQFW
     SRKAAAELTP HKKSFIFQQL EVDYAELKEP VPGMPGPKKG PLPVIRMFGI TKEGNSVLCK
     VHGFLPYFFI QCPPGFTSQH CKSMKDTLNE QMIGYYQRDK DFEIGDIVIS IDIIQKKSIM
     FYNNDPLSDF IMITLIMPKY VTRCRETLEN MSSRYIIPGQ PLRSYVTYES NIPFALRFLI
     DKNIAGCSWI ELPATTYQES ATKVSTCQYE IDTSIHTLIT HSPDSEGWSD TAPFRILSFD
     IECAGRKGFF PEPEKDPVIQ IANVVKHQGE QTPFIKNIFT LKSCSSIVGA HVLSYETERE
     LLREWRKFIV KLDPDIIIGY NIANFDLPYL INRARTLKVN DFALLGRIKT TISKIKTANF
     SSKNLGSRES KEISMPGRTQ LDMIQAIQRD HKLSSYSLNN VSAHFLKEQK EDVHFSIISD
     LQNGTDDDRR RLAVYCLKDA MLPLKLLDKL MILINYVEMS RVTGVPLSYL LGRGESVKVL
     SQLYRKAMKE DYVLPTYKVN TKGEKFQGAV VIEPKSGFYN VPIATLDFTS LYPSIMMAHN
     LCYSTLIPPD QAKTMSPDEY THTPSGDYFA LPSLKKGLLP RILEELLGAR KKAKDDLKNE
     SDPFKKAVLD GRQLALKISA NSVYGFTGAR VGKLPCIEIS RSVTSFGRVM LNKTQEIVEG
     RYTVANGYSH NATIIYGDTD SVMVKFGVET VEEAMQLGRE ASKEVTKHFI RPINLDFEKV
     YYPYLLMSKK KYAGLFWTKP NTWDKMDVKG LEMIRRDTCP LVRNVVGNVL KKLLIERNVQ
     AAEDYVKSVV SDLLQGRLDI SMLVITKALS KSEYKSRTVH NELAQRMRAR NPATAPNLGD
     RVPYVVIQAT KGTPIYEKAE DPLYVLEHNK LLDTQYYCDK QLKGPIDRIF KPIKNSTTSL
     FVGEHTRVVA QSSMSSTNKG FFGTLEKKRV CMNCPNELLP NEQTVCKNCR HKESDLYLTT
     LENVGHLETK FANAWTHCQR CSGSLMQPVL CSNRDCPIFY MRTKVQKDLI EAKNQLARFD
     VDW
//
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