ID A0A154NBM6_9SPHN Unreviewed; 515 AA.
AC A0A154NBM6;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:KZB96981.1};
GN ORFNames=AVM11_02210 {ECO:0000313|EMBL:KZB96981.1};
OS Sphingomonas melonis TY.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=621456 {ECO:0000313|EMBL:KZB96981.1, ECO:0000313|Proteomes:UP000078460};
RN [1] {ECO:0000313|EMBL:KZB96981.1, ECO:0000313|Proteomes:UP000078460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TY {ECO:0000313|EMBL:KZB96981.1,
RC ECO:0000313|Proteomes:UP000078460};
RA Wang H., Zhu P.;
RT "Sphingomonas melonis TY, whole genome shotgun sequencing.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KZB96981.1}.
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DR EMBL; LQCK02000001; KZB96981.1; -; Genomic_DNA.
DR RefSeq; WP_018250743.1; NZ_LQCK02000001.1.
DR AlphaFoldDB; A0A154NBM6; -.
DR STRING; 621456.BJP26_08655; -.
DR OrthoDB; 462203at2; -.
DR Proteomes; UP000078460; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2}.
FT ACT_SITE 84
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 18..21
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 84
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 341
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 350
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 354
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 515 AA; 57931 MW; 322B25CEEE0F6A66 CRC64;
MTLPVPDHAI RSIVIVGGGT AGWMAAAAFS RLLNTGYTRV TLIESEEIGT VGVGEATIPP
LLNFNRMLGI DENEFLAATA GTFKLGIEFR DWGAIGDRYI HPFGTFGQDL QGISFHQLWL
RERSRRAIPD ITAWSMSAQA AARGRFGRAR EDARSPVREL FYAYHFDASL YARYLRGYAE
RGGVTRIEGR IADVRLRGED GYVEALTLVD GRQVAGDLFI DCSGFRGLLI EEALHTGYES
YAQWLPCDRA VAVPCALPSA REPDPYTRAT ARAAGWQWRI PLQHRMGNGY VYCSEFLSDE
AAEFDLLASL EGEPLGDPRR LRFTAGRRRQ SWNRNVIALG LSSGFIEPLE STSIHLVQAG
IQRIVAMFPD TRFDPAERDE FNRQLHDLYE DIRDFIILHY AQTRRTDTPF WDRVRTMPLP
DSLTRKLELW RGKGRLFREG YDLFSVPSWV AVCLGQGLVP STWEPAADAL DETLVAEAME
TMRRGYADTA ERLPTHGDFL RMVAPSPLAN WGQTR
//
