ID A0A154NZX7_DUFNO Unreviewed; 667 AA.
AC A0A154NZX7;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 13-SEP-2023, entry version 29.
DE RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
DE Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
DE Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
DE AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
DE Flags: Fragment;
GN ORFNames=WN55_00720 {ECO:0000313|EMBL:KZC04644.1};
OS Dufourea novaeangliae (Sweat bee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Halictidae; Rophitinae; Dufourea.
OX NCBI_TaxID=178035 {ECO:0000313|EMBL:KZC04644.1, ECO:0000313|Proteomes:UP000076502};
RN [1] {ECO:0000313|EMBL:KZC04644.1, ECO:0000313|Proteomes:UP000076502}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0120121106 {ECO:0000313|EMBL:KZC04644.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KZC04644.1};
RA Pan H., Kapheim K.;
RT "The genome of Dufourea novaeangliae.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
CC Nucleus {ECO:0000256|RuleBase:RU361195}.
CC -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
CC {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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DR EMBL; KQ434782; KZC04644.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A154NZX7; -.
DR STRING; 178035.A0A154NZX7; -.
DR EnsemblMetazoa; XM_015578822.1; XP_015434308.1; LOC107190085.
DR Proteomes; UP000076502; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009791; P:post-embryonic development; IEA:UniProt.
DR GO; GO:0050793; P:regulation of developmental process; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051239; P:regulation of multicellular organismal process; IEA:UniProt.
DR CDD; cd10492; MH1_SMAD_4; 1.
DR CDD; cd10498; MH2_SMAD_4; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 3.90.520.10; SMAD MH1 domain; 1.
DR InterPro; IPR013790; Dwarfin.
DR InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR InterPro; IPR013019; MAD_homology_MH1.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036578; SMAD_MH1_sf.
DR PANTHER; PTHR13703:SF45; MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG; 1.
DR PANTHER; PTHR13703; SMAD; 1.
DR Pfam; PF03165; MH1; 1.
DR Pfam; PF03166; MH2; 1.
DR SMART; SM00523; DWA; 1.
DR SMART; SM00524; DWB; 1.
DR SUPFAM; SSF56366; SMAD MH1 domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS51075; MH1; 1.
DR PROSITE; PS51076; MH2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|RuleBase:RU361195};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
KW Reference proteome {ECO:0000313|Proteomes:UP000076502};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361195};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 41..165
FT /note="MH1"
FT /evidence="ECO:0000259|PROSITE:PS51075"
FT DOMAIN 443..667
FT /note="MH2"
FT /evidence="ECO:0000259|PROSITE:PS51076"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 60..87
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KZC04644.1"
SQ SEQUENCE 667 AA; 71678 MW; 05651206465E6422 CRC64;
VGLAGRGGHL YPSPPMQPNP EVREMTGMAP TAPTSADACL SIVHSLMCHR QGGESEGFSK
RAIESLVKKL KEKRDELDSL ITAITTNGAH PSKCVTIQRT LDGRLQVAGR KGFPHVIYAR
IWRWPDLHKN ELKHVKYCQF AFDLKCDSVC VNPYHYERVV SPGIDPFFTD LSGLTLQSGV
GVGPGGRLVK DEYSVGGGGT TAAGAVGTTM DVDEEMNQTI QHHPPAQSNS SNNTQSSQQT
FIPGLAPSNP TSGEGIFGSN VGENNGGNPH NKLDDSNCPR QTWIPTPHRP TTRNIHHSVV
HPMSHTVGSQ QQSSTTSSGG NGTQMLNPSQ GQSTEAFYGT NTPPQDLNQS PSVDALAVTL
GNGQNSPVSS VHIHHPNGFP IGTTAYNSGA PQWTGANTLT YTQSMQPPDH RHLHPTSYWV
GHSGDVGGNI GGLLSTQPAP EYWCSVGYFE LDTQVGETFK VSSGCPTVTV DGYVDPSGGN
RFCLGALSNV HRTEQSEKAR LHIGKGVVLD LRGEGDVWLR CQSEHSVFVQ SYYLDREAGR
APGDAVHKIY PSACIKVFDL RQCHKQMRGQ AATAQAAAAA QAAAVAGHLT HGAPITKSLS
AAAGIGVDDL RRLCILRLSF VKGWGPDYPR QSIKETPCWI EVHLHRALQL LDEVLHTMPI
DGPRGIE
//
