ID A0A154P1I7_DUFNO Unreviewed; 2907 AA.
AC A0A154P1I7;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Filamin-A {ECO:0000313|EMBL:KZC05098.1};
GN ORFNames=WN55_08705 {ECO:0000313|EMBL:KZC05098.1};
OS Dufourea novaeangliae (Sweat bee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Halictidae; Rophitinae; Dufourea.
OX NCBI_TaxID=178035 {ECO:0000313|EMBL:KZC05098.1, ECO:0000313|Proteomes:UP000076502};
RN [1] {ECO:0000313|EMBL:KZC05098.1, ECO:0000313|Proteomes:UP000076502}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0120121106 {ECO:0000313|EMBL:KZC05098.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KZC05098.1};
RA Pan H., Kapheim K.;
RT "The genome of Dufourea novaeangliae.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KQ434786; KZC05098.1; -; Genomic_DNA.
DR STRING; 178035.A0A154P1I7; -.
DR Proteomes; UP000076502; Unassembled WGS sequence.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd21227; CH_jitterbug-like_rpt1; 1.
DR CDD; cd21229; CH_jitterbug-like_rpt2; 1.
DR CDD; cd21185; CH_jitterbug-like_rpt3; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 23.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 3.
DR Pfam; PF00630; Filamin; 21.
DR SMART; SM00033; CH; 3.
DR SMART; SM00557; IG_FLMN; 21.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 2.
DR SUPFAM; SSF81296; E set domains; 23.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 22.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000076502};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 39..148
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 154..257
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 377..453
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 455..543
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 548..633
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 965..1056
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1066..1143
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1141..1237
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1235..1324
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1322..1415
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1424..1504
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1502..1596
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1610..1683
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1693..1773
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1784..1862
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1860..1952
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1956..2041
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2115..2215
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2216..2310
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2308..2402
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2400..2491
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2589..2682
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2683..2776
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2777..2873
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 630..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 910..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..803
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2907 AA; 313147 MW; 2DFB9D6A6F635EFA CRC64;
MERTEQLRPE QLVGLVARSA EGTAAKGMPI KGHEDLWVEI QANTFRNWVN EHLKHAADVA
DGPVIDLAED FRDGTRLCAL VEVLTNRRLP RWNPRPANQH HHLENVSTAL QAIEADGVKL
VNIGNVDIVN GNLKLILGLI WSLIVRYQIG KSKFPPRKLM LAWLKAVLPE CRVNNFTTDW
NSGVYLSALL NYCQPGLFSH WRQLDPNDSV YNCRKAMEIS KREFDIPMVL EPEYLASPYL
DELSGMTYLS YFMKEGSPGF HATLRWVNTQ LPHHTVQNFK TDWNDGRVLC GIVRNLGGSA
PAYEKIDTDP SAWEHNNQMG IDGGKKLGVE PILKAKDMAD QNVEHLGVMA YAAYFQWVKP
RPQACKQIVV HIDSTSARVQ QPAHFKLEML TKEVNTREVR GEVISPSGRI ECRLAWNGVH
GKGTFIPTEI GMHKLMVYND GELVDGCPYY FRVLPSLTKI KASGMDPCAI GSIVEVLVNS
YGTSHDGIDV TAWSPTGRSL SCPVKENDGV HTATFQPDET GEWSIAITHK GNHIQGGPFT
CFVFDPNGIK LMDTDGAVPG QPFSFIVDAT GTGGLGDVII DLVHDKQSVP FRMEDYGHMR
YRVSFVPSES GKYRVYVYFN GSDVRGSPFS IRVGSQKGSR RSKESTSSLE RSKLSSLERR
MNGLNVSVGA DRSSPVQKTY SSSAYKSSIS RNLHSPSMIK ETKEMNSSTV YNQVRSSPTV
QSPNLLKESK DIYVSNTVSS SRSPNPSPTT HAPRLASPII KETREIYNSG SLKRSRSPNR
SPMAYRSPTQ SPVNRSFSPR NNDRENGFNR RGSMDNGAID TSSNVRVSSM VGGTSRRDSW
DAIEKTKSLL SYGSLESLAN LTNNSPTAES TNNHSYLNNN YKNTQAYGTR NATHTNNSFS
NFTSSQKLTS ADYSPSQKYN NENPNARTQT HGILKNKNNN YYKSMDTTDG VHDHRYLNNG
VSGYAATQSK NSVLVTGSAL EMLPLHRPTV FTVDPSVDPN NVTVNVSGPN GKVIPVQKST
LRGLTYAVTA EEVGEYTIQI LVNGQHVPGS PFRSQAYNAR AIQIGNIPNG VVNQPVEFEI
DGSRAGSGNL EILVNGGHVT SFVRALGSQR FLASFVPHEA VVHLVEMTFN GELVPGSPWR
VGIMPAPKMS VIGDSVRLVP AGSPALFELS ALGFTSSEID VQIITPSKRH LPARIEEEPG
RPGEFRVQFT PTDVGSHLVE VSIAGQKLPA GPLVAKVYNS SLIQVTDVPS AVVGHACQFR
VDASAAGEGQ LEISINEGEV PNHVQVVGGG RCLVSFTPEI AKPHYIDIKF NGEAVKGCPF
ICNVSDTSRV TLSLNHLELI PVDQPASFHM GVDGSGSAEL AVSVRGPNSE LPVKVTGDIK
SGFTAEFIPR DVGVHSISVE YNGHPVNGTP FLAKAFNADK VLIGPVARGS VGQPTHFTVD
ASQAGEGNLE ITISARNQNI PTQVTPQGNA RFSVSFVPFE ACEHVINIAF NKRTVPGCPI
VTRVGGDSHV TVSGQALNSA GLGRQSYLTV SNVAGSLEDL EVNVEGPNGQ AVPAQVTDNK
DTTCSVAFTP RVVGEHRISV SHRNVPVVGS PFSCKVYDVT AIKVKDAKHG VIGMPVTFLV
ETSQAGPGNL EVTVNGGRVP TSAQAQGPHT YAISFTPREP LVHTVDLRFN GEDVPGSPFS
CQVSDTAKVV ITEGLEKVSV NRLTTFTIEA DASLGTPIVE VLSPTRDSLP IHVKQNGHGC
YTAGFTPKDV GDHSVEVKLS GSHVEGSPFL VKAYNADKVK VTDINSGVVG KPVFFSINAS
QAGAGNLEII VAVNGKNVPN YVQSEGNAKF RVNFKPQEAA VHSLSVRFNG EPVPGSPFSC
KVVGAGQAII AGHNLKMGAV KQLMSFAVDP QAASTNCDVI VTPPSGISLP ITIEPVDGKY
NISFAPMEVG RHNISVLVDN EHVKGSPFAC NIYDVTKVHV SGLTEALLGQ ATTFTVDAAE
AGEGTLELVV STENNTVKAE VVACARGLYD VTFVPQTTST HYVNISFNDD NVPGSPFKCP
VVSTMIDGPS MIRVGNIAYM DLEMPGLEGP VSAEVTGPDG IIIPCTLTKL SSHLYRVEIR
TRQVGTYSVI FSDGHKIISS QTLQAFDPGK VTIKEVSDVV CHRPGTIIVV ASKEAGPGKL
SVNVRSAGTD VDSVVREGDN NVYEIVFHPT RAAPHRVHIK YNEVHIAGSP LDISVRSPTG
GREVTATGLG LYQSCVGKVT SFTIETLGRP GKEFDVVISG PQGNAVPVRC YQHRDGNLLA
EFTTNTVGTY KIDVLQGAKP VLGSPFFCQA FDVSKVKLQE LGPMTVSVHD HIAFKIMKTD
AGIADLDVAA TSPLGHELPL QVTPLNDGAE MVEFSPSVPG SYMINITYGG CPIPGSPLVC
AVDAAGQARA KGEGLLSGHV DKPAHFIVTG TRSPPAVQVD GPDSVSKAVV EAGANPGTWN
VSYVPTEVGV FDIRVVSAGQ QLPGSPWHPK IIDTRNLRVI GGWSAVCDEL GRLKLHSSNK
ISFDTAEAGP GELTGKIGDQ MLSFEMSSNN RLKLIAPQLN GGEHRLEILF NGIPFPGAPK
LAIVQDLEPP VQDTSRVLLR GRGLTSAKCG EEVSFTIDGS QAGNGTPKVQ LFSPTNELNV
MLQHLGDSVY RASYIPLTPD PLLMTVSWNG RQLKGCPLQI NVTSAADASR VICSGDGLKN
GIVGQEIRSF IDTRRAGPGE LTAHCVGPHK VAYCELYDHG DATFTLNVKP QEAGRHALTI
KYAGEHVPGS PFTLRVSGAP DASKVRVYGP GIEHGVLATF QSRFICDTRG AGAGQLTVRV
RGPKGAFRVE MQRETQKDRI ILCRYDPTEP GDYRVEVRWA GVLVPGSPFP VKIVDTQDEL
LMLTQGGDNY STGHHTIASW RGSQAIL
//
