ID A0A154PF18_DUFNO Unreviewed; 980 AA.
AC A0A154PF18;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Insulin-degrading enzyme {ECO:0000313|EMBL:KZC10034.1};
GN ORFNames=WN55_01785 {ECO:0000313|EMBL:KZC10034.1};
OS Dufourea novaeangliae (Sweat bee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Halictidae; Rophitinae; Dufourea.
OX NCBI_TaxID=178035 {ECO:0000313|EMBL:KZC10034.1, ECO:0000313|Proteomes:UP000076502};
RN [1] {ECO:0000313|EMBL:KZC10034.1, ECO:0000313|Proteomes:UP000076502}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0120121106 {ECO:0000313|EMBL:KZC10034.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KZC10034.1};
RA Pan H., Kapheim K.;
RT "The genome of Dufourea novaeangliae.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; KQ434885; KZC10034.1; -; Genomic_DNA.
DR RefSeq; XP_015431903.1; XM_015576417.1.
DR AlphaFoldDB; A0A154PF18; -.
DR STRING; 178035.A0A154PF18; -.
DR EnsemblMetazoa; XM_015576417.1; XP_015431903.1; LOC107188169.
DR GeneID; 107188169; -.
DR OrthoDB; 129328at2759; -.
DR Proteomes; UP000076502; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000076502};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 35..171
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 198..375
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 382..662
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 666..849
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 980 AA; 114107 MW; 4A1B40C410FCF81A CRC64;
MLLHDYIEKR YDNITKSPND KREYRGLLLT NKMKILLISD ETTDKSAAAL DVNIGFFSDP
YDLPGLAHFC EHMLFLGTKK YPKENEYNMY LSQNGGSSNA TTYFDHTTYF FNVHPEKLEG
ALDRFSQFFI APLFTEALTE LELNAINSEH EKNKANDTWR IDQLEKSSAN PNHPFSKFGT
GNRETLDVIP KQKNINVREK LFQFHQNFYS ANIMALCVLG KESLDELEKI TVELFSQIRN
KKVEVPVWSK HPFNEEHFQH KWYIVPIKDT RSLNITFGIP DTRAYYKSAP SYYISYLLGH
EGKGSLLSSL KAKGWCNSLV SGKRAAAKGF NFFNVLVDLT EEGIQHVDDI ILLTFQYINM
LKTHGPIQWI YNEYRDIADM NFKFKEKSSA YQYVVGLIHT IQEYPMEEVL VAGHLFPTWQ
PDLINWIMEY LVPTKVRILV IGKLFESITD ESEKWYGTKF KKEKISQDII DIWLNAGYCS
DFKLPLKNEF IPKKFDIKQA ENITKFPTII EDTPLLRLWF KQDDEFLVPK ATISLQFVSP
LAYIDPLSYN LTYMYVQLLH DALNEYAYAA DIAGIKWEVS SSKYGITVGI SGYDDKQQIL
LERILDKMLN FEVDPKRFDI LKENCIRDLK NFETEQPYQH AVHYLAVLLS EQVWMKDELL
RATSQLTVER TQQFIPQFLS KVHMECLIHG NITLSEAIET ANFIESKLKN AIPQIIPLLP
RQLILYREIR LEDGCHFLFE VQNKLHSSSC TQVYYQIGLQ STESNMLLEL LVQLISEPCF
STLRTKEQLG YIVFSGVRRG NGAQGFRIIV QSDRHPKYVE QRIDTFLKSM LEYISEMSDE
EFKRHKEALS VLRLEKPKML TTLSAVFWHE ILNQQYNFDR TNIEVAHLKT IKQEEIVQFY
KNVLQRNIQH KLSVHVIPMV TNEESMKKDA DENIEFSDAT DTTEYRKIDD ITAFKINQPL
HQLLKPFTNV PRKGGHASKL
//