ID   A0A154PNI8_DUFNO        Unreviewed;       797 AA.
AC   A0A154PNI8;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Carnitine O-palmitoyltransferase 1, liver isoform {ECO:0000313|EMBL:KZC13402.1};
GN   ORFNames=WN55_05991 {ECO:0000313|EMBL:KZC13402.1};
OS   Dufourea novaeangliae (Sweat bee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC   Anthophila; Halictidae; Rophitinae; Dufourea.
OX   NCBI_TaxID=178035 {ECO:0000313|EMBL:KZC13402.1, ECO:0000313|Proteomes:UP000076502};
RN   [1] {ECO:0000313|EMBL:KZC13402.1, ECO:0000313|Proteomes:UP000076502}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=0120121106 {ECO:0000313|EMBL:KZC13402.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KZC13402.1};
RA   Pan H., Kapheim K.;
RT   "The genome of Dufourea novaeangliae.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232}.
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DR   EMBL; KQ435005; KZC13402.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A154PNI8; -.
DR   STRING; 178035.A0A154PNI8; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000076502; Unassembled WGS sequence.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 6.10.250.1760; -; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   InterPro; IPR032476; CPT_N.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR22589:SF31; CARNITINE O-PALMITOYLTRANSFERASE; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   Pfam; PF16484; CPT_N; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076502};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KZC13402.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        61..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        100..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..46
FT                   /note="Carnitine O-palmitoyltransferase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16484"
FT   DOMAIN          174..774
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        471
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   797 AA;  91705 MW;  DFAF6F001CF45FA2 CRC64;
     MAEAHAAVAF SFSITHEGWD VNLDREVLHL VWQSGVRSWK KRFFRFLNNL KSGVYPASLR
     SLWFTIALVT VIHFAGYRIP YDLVGKTVPY LSGSSILTHL AGSFVVGLLL WLVVIYVLRY
     TLKLLLIYKG WMYESREKGY KISKTTRIWT LLVKLLIGWR KPMLYSFQGS LPRLSLPSVE
     ETMKRYLRSV RPLLDDENYA RMETLATEFQ NGIGVKLQRY LILKSWWATN YVSDWWEEYV
     YLRGRSPIMV NSNFYGIDAI LMHPTTVQAA RAANVVYSCL QYRRLIEWQE LEPILVQGLV
     PLCSWQYERL FNTTRIPGRE TDRIVHYQDS KHVVVYHKGR YFKVPIYYKN RILQPSELEL
     QMHQILHDQS EPSVGEEKLA ALTAGERPTW ARAREEFFVK GVNKASLDLI EKAAFVVVLD
     NIPYIYDPAN PEKLDQYGRI LLHGKGYDRW FDKSFTLCIG NNGRIGFNAE HSWADAAVMS
     HLWEYVMSQE ASNRQADAPI MGSLWEFVIG NEVKMGYTED GHNKGEPEFT PPPPTRLQWD
     LTQGCIDAIE ESAQIAEKLL NDVDLRIYVH DDYGKGFMKI NSMSPDAYIQ MALQLAYFRD
     SNKFNLTYEA SMTRLFREGR TETVRPCTIE STEWVKAMHD NDATVEHKYK LLTAAAKQHQ
     KGYQNAMSGK GIDRHLFCLY VVSKYLEVDS PFLKEVLSEP WKLSTSQTPH GQTSLINLKK
     YPNCISAGGG FGPVADDGYG VSYIIAGENL IFFHISCKVS SPETNANRFA KHIQRALADM
     KNLFNERQKL QKKNGSA
//