ID   A0A154PRT3_DUFNO        Unreviewed;       847 AA.
AC   A0A154PRT3;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Regulator of nonsense transcripts 1 like protein {ECO:0000313|EMBL:KZC14447.1};
GN   ORFNames=WN55_06907 {ECO:0000313|EMBL:KZC14447.1};
OS   Dufourea novaeangliae (Sweat bee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC   Anthophila; Halictidae; Rophitinae; Dufourea.
OX   NCBI_TaxID=178035 {ECO:0000313|EMBL:KZC14447.1, ECO:0000313|Proteomes:UP000076502};
RN   [1] {ECO:0000313|EMBL:KZC14447.1, ECO:0000313|Proteomes:UP000076502}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=0120121106 {ECO:0000313|EMBL:KZC14447.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KZC14447.1};
RA   Pan H., Kapheim K.;
RT   "The genome of Dufourea novaeangliae.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC       {ECO:0000256|ARBA:ARBA00007913}.
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DR   EMBL; KQ435078; KZC14447.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A154PRT3; -.
DR   STRING; 178035.A0A154PRT3; -.
DR   EnsemblMetazoa; XM_015581923.1; XP_015437409.1; LOC107192619.
DR   Proteomes; UP000076502; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR   CDD; cd21407; 1B_UPF1-like; 1.
DR   CDD; cd18039; DEXXQc_UPF1; 1.
DR   CDD; cd21400; ZBD_UPF1-like; 1.
DR   Gene3D; 2.40.30.230; -; 1.
DR   Gene3D; 6.10.140.1240; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR040812; UPF1_1B_dom.
DR   InterPro; IPR018999; UPF1_CH/ZBD.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF18141; UPF1_1B_dom; 1.
DR   Pfam; PF09416; UPF1_Zn_bind; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51997; UPF1_CH_RICH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000076502};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT   DOMAIN          99..256
FT                   /note="Upf1"
FT                   /evidence="ECO:0000259|PROSITE:PS51997"
FT   REGION          39..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          107..139
FT                   /note="C3H"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          121..149
FT                   /note="CC/SHH/C"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          167..197
FT                   /note="C4"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          728..847
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   847 AA;  94652 MW;  F32198E1A07451F5 CRC64;
     MSVDAYGPSS QTLTFLDPEE ADLIGADTQG SEFDFTDFTL PSPSQTQASQ HDVVQSQPSQ
     PVQVNGTSGG SSLELKISGA AQSLAELQFE EEEEEAYYNR DLPEHACKYC GIHEASCVVM
     CNVCRKWFCN GRGNTSGSHI INHLVRAKHK EVTLHRDGPL GETILECYSC AVRNVFVLGF
     IPAKADSVVV LLCRQPCAAQ SSLKDMNWDQ EQWKPLIEDR SFLAWLVKIP SEQEQLRARQ
     ISAQQINKLE ELWRDNVDAT FQDLEKPGVD EEPQQVLLRY EDGYQYQNIF GPLVKLEADY
     DKRLKESQTQ ENIEVRWDVG LNKKTIAYFM LAKTDGDMKL MHGDELRLRY LGELHKPWSG
     IGHVIKIPDN YGEEVGIELK NNSGAPTECI SNFVVDFIWK STSFDRMQLA LRKFAVDDSS
     VSAYIYHRLL GHEVEEVLFR CHLPKHFSAP NLPDLNRSQV YAVKHAVQRP LSLIQGPPGT
     GKTVTSATIV YQLVKQNGGP VLVCAPSNTA VDQLTEKIHK SNLKVVRLCA KSREAIDSPV
     SFLALHNQIK NMETNTELQK LQQLKDETGE LSSVDEKRYR LLKKAAEKEL LEAADVICCT
     CVGAEQKVLV EGPLNNLKES MIQFAKPKKL VNAANPGSHF MSTSMYDARE ALIPGSVYDR
     SGTQVNGTQN HNPYYQRNVP LDIFSRTHDT ISYISPERAQ AAMNNVPVPV GMFMNMAHVP
     PRFYNQHQQA LQARQNQRNR RGTALSKNKQ GPRMGKLSQT EQNNTQPYSQ PGLPLTQGTT
     QGMSQPGFSL SQPGLSQAEL SQDSFAVGEF QSQMDGLLSQ DSTYQGDRSG FYQSGQSQAG
     GQFSQPY
//