ID A0A158AEQ8_9BURK Unreviewed; 326 AA.
AC A0A158AEQ8;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=2-hydroxyacid dehydrogenase {ECO:0000313|EMBL:SAK56220.1};
GN ORFNames=AWB75_02097 {ECO:0000313|EMBL:SAK56220.1};
OS Caballeronia catudaia.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Caballeronia.
OX NCBI_TaxID=1777136 {ECO:0000313|EMBL:SAK56220.1, ECO:0000313|Proteomes:UP000054870};
RN [1] {ECO:0000313|EMBL:SAK56220.1, ECO:0000313|Proteomes:UP000054870}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 29318 {ECO:0000313|EMBL:SAK56220.1};
RA Oliw E.H.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
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DR EMBL; FCOF02000007; SAK56220.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A158AEQ8; -.
DR OrthoDB; 9805416at2; -.
DR Proteomes; UP000054870; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05301; GDH; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 4..310
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 107..284
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
FT REGION 307..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 326 AA; 35384 MW; D28CFC99590E6875 CRC64;
MKKVLVARPT FPDVIERLKQ YFDVDANPGD VLPQDEFARR LADKDGAFTA GERVGEKELA
GAPNLKVVAN MAVGYNNFDM HAFDAHGVLG TNTPNVLNET TADFGWALMM AAARRVTESE
HYLRAGKWQK WSFDSFLGAD VYGSTLGVIG MGRIGQALAR RAIGFNMRVI YHNRSRVAPE
IEAELNAEYA SKEDLLKRAD HVVLVVPYSK ESHHTIAAAE LALMKPTATL TNIARGGIVD
DAALIVALRE KRIAAAGIDV FEGEPDFDRD FLALDNVVLT PHIASATEGT RRAMANLAAD
NLIAALGEGP RAGNPPNPIN PDVLKK
//
