ID   A0A158F8Q5_9BURK        Unreviewed;       570 AA.
AC   A0A158F8Q5;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Na+:H+ antiporter {ECO:0000313|EMBL:SAL16164.1};
GN   ORFNames=AWB64_00946 {ECO:0000313|EMBL:SAL16164.1};
OS   Caballeronia sordidicola.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Caballeronia.
OX   NCBI_TaxID=196367 {ECO:0000313|EMBL:SAL16164.1, ECO:0000313|Proteomes:UP000054893};
RN   [1] {ECO:0000313|EMBL:SAL16164.1, ECO:0000313|Proteomes:UP000054893}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 22029 {ECO:0000313|EMBL:SAL16164.1};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC       external protons. {ECO:0000256|RuleBase:RU366002}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU366002}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU366002}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU366002}.
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DR   EMBL; FCOC02000002; SAL16164.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A158F8Q5; -.
DR   Proteomes; UP000054893; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   Gene3D; 6.10.140.1330; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR   NCBIfam; TIGR00831; a_cpa1; 1.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU366002};
KW   Cell inner membrane {ECO:0000256|RuleBase:RU366002};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU366002};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU366002};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU366002};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU366002};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        43..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        100..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        172..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        197..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        233..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        295..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        330..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        411..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   DOMAIN          20..434
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
SQ   SEQUENCE   570 AA;  61212 MW;  3DEBCC5E6760CECE CRC64;
     MKYPRAYCSE PMDIVFTVLI LMLAVALSGY ITSALASKLP FTLPLPLIQI AIGACLAWPG
     FSLHVTFDPE LFMMLFIPPL LFADGWRIPK REFFMQRRAI LLLALGLVFM TVGALGWFLH
     VMIPVMPLPV AFALAAVLSP TDAVALSGIA GKGRIPANLM HILEGEALMN DASGLVALKF
     AIAAALTGVF SLRAASISFV VIAVGGLVIG AAISWLATTI PRRIVKMSED DDPAAGVILT
     LLIPFAAYLI AEKLGCSGIL AAVSAGMMMN FQSLREIVPT ASRIRMTSTW TMIEFVFNGM
     VFILLGLQFP HIIGRALIEA HHDGLYQVGL LLGYVAAVVI ALYGLRFAWV WVLRWVASRG
     AAKHGVANAV PGARTLAMTT IGGVRGAVTL AGVLSLPEVL PNGTALPGRD LAIFIASGTI
     LMSLLIGVIG LPLLINGLKR RGDPHAAEER IARRHAAQAA IRAIDAAQEN LTGQMDETGA
     AHCADSTARV MSLYRRRLEG LGDEEESRRA ARQSEMVETK LKMAALRAER AELLKLRTRQ
     AINDETLNKL MREIDLSETA IVTRKKGAGA
//