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Database: UniProt
Entry: A0A158GVU9_9BURK
LinkDB: A0A158GVU9_9BURK
Original site: A0A158GVU9_9BURK 
ID   A0A158GVU9_9BURK        Unreviewed;       463 AA.
AC   A0A158GVU9;
DT   06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT   06-JUL-2016, sequence version 1.
DT   05-DEC-2018, entry version 14.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   ORFNames=AWB64_03658 {ECO:0000313|EMBL:SAL36304.1};
OS   Caballeronia sordidicola.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Caballeronia.
OX   NCBI_TaxID=196367 {ECO:0000313|EMBL:SAL36304.1, ECO:0000313|Proteomes:UP000054893};
RN   [1] {ECO:0000313|EMBL:SAL36304.1, ECO:0000313|Proteomes:UP000054893}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 22029 {ECO:0000313|EMBL:SAL36304.1};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR   EMBL; FCOC02000011; SAL36304.1; -; Genomic_DNA.
DR   RefSeq; WP_060856796.1; NZ_FCOC02000011.1.
DR   EnsemblBacteria; SAL36304; SAL36304; AWB64_03658.
DR   GeneID; 34119074; -.
DR   Proteomes; UP000054893; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000054893};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124}.
FT   DOMAIN      324    436       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    270    270       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      86     86       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     121    121       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     158    158       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     273    273       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     338    338       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   463 AA;  50737 MW;  2B682C80D2052DB9 CRC64;
     MKLTIIGSGY VGLVTGACLA DIGNDVFCLD LDERKIAILN GGGVPIHEPG LQEVIARNRA
     AGRLTFSTDV KAAVEHGEVL FIAVGTPSDE DGSADLKYVL AAARDIGRYM NNFKVIVDKS
     TVPVGTARRV KAAIDQELAE RGESHMFSVV SNPEFLKEGA AIDDFTRPDR IVLGCDDDVP
     GERARERMKR LYSPFNRNHE RTLYMDVRSA EFTKYAANAM LATRISFMNE LANFADRVGA
     DIEAVRRGIG SDPRIGYDFL YAGCGYGGSC FPKDVRSLIQ TAGEYDEQME ILKAVTSVNE
     AQKQTLANKI VARLGNDLSG KKFALWGLAF KPNTDDMRDA PSRILIAALL ERGATISAYD
     PVATDEAQRV IALDLRDTPE QLSRLSYAKD HAETLDGADA LIIVTEWKAF KSPDFDGMKR
     RLKTPLIFDG RNLYEPETMA EIGIEYHAIG RGVRQAAKSP VTA
//
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