ID A0A158GZ41_9BURK Unreviewed; 718 AA.
AC A0A158GZ41;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase {ECO:0000313|EMBL:SAL36859.1};
GN ORFNames=AWB64_03764 {ECO:0000313|EMBL:SAL36859.1};
OS Caballeronia sordidicola.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Caballeronia.
OX NCBI_TaxID=196367 {ECO:0000313|EMBL:SAL36859.1, ECO:0000313|Proteomes:UP000054893};
RN [1] {ECO:0000313|EMBL:SAL36859.1, ECO:0000313|Proteomes:UP000054893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 22029 {ECO:0000313|EMBL:SAL36859.1};
RA Oliw E.H.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FCOC02000011; SAL36859.1; -; Genomic_DNA.
DR RefSeq; WP_060856875.1; NZ_FCOC02000011.1.
DR AlphaFoldDB; A0A158GZ41; -.
DR OrthoDB; 9787650at2; -.
DR Proteomes; UP000054893; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR007470; HemX.
DR PANTHER; PTHR38043; PROTEIN HEMX; 1.
DR PANTHER; PTHR38043:SF1; PROTEIN HEMX; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF04375; HemX; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Methyltransferase {ECO:0000313|EMBL:SAL36859.1};
KW Transferase {ECO:0000313|EMBL:SAL36859.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..262
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 284..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 450..477
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 294..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 718 AA; 75952 MW; E70553A08786188B CRC64;
MRQSTVVITR PSGQSIALIA MLERAGFAPF EFPLIDIGPA ADTAPLQAAL GELYAPAELG
FALVVFVSPN AIQHAFAALS APWPTHVALG VVGPGSVAAL ARQGIAAPAY TVISPGADAT
ITETPTDPRY DSEALYAAIM SHFGPDGLKN KRVLIVRGDG GREWLADTLV DAGANVEKVA
AYTRIVPEPS MRDWERIHEL LSGEPHAWLL TSSEGVRNLE ELAREYLTAD ETLTLKHVPL
VTPHPRIAEA ARQAGFDRIT VSGAGDERIV QAFSALLNPA SVPDAKVSER QEQGYAASAA
TPPGQSGQKI NPESAPTDSR PASAPAHQPA QSRMTDSIDS SKAASKPDPK SDPKSAASAA
PSNPPNTPFT PYESQPPKQR RGGAGTALLW LVLVIIVVVA GVGGFMLNRK FDQRDAQLAQ
RMQANDAQTA ALRAQADQAA SSVNAINTQI IQFQGKLTDA QAQSQALQQQ YQDLASNRDD
WTLAEVEQIL SSASQQLQLT GNVQLALFAL QSADTRLAAT TGPQIVTIRK AIAQDMDKLH
ATPSTDLTGL AIKLDTAIDQ IDRLPLAGEA AIVPATAHAD TPGDSAAIAA ATNQPRWKVW
LQQLAGGIGQ QLSSLVSVRR IDNADAMLAS PDQGYFVREN VKLRLLSARL SLLSRSEPAL
KSDLNAADTA LGRYFDASSG KVKSVRDLIK QVNDASTAVA VPDLNASLAA VHQFKRGG
//
