ID   A0A158GZA6_9BURK        Unreviewed;       822 AA.
AC   A0A158GZA6;
DT   27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT   27-SEP-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:SAL37396.1};
GN   ORFNames=AWB65_02741 {ECO:0000313|EMBL:SAL37396.1};
OS   Caballeronia humi.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Caballeronia.
OX   NCBI_TaxID=326474 {ECO:0000313|EMBL:SAL37396.1, ECO:0000313|Proteomes:UP000054977};
RN   [1] {ECO:0000313|EMBL:SAL37396.1, ECO:0000313|Proteomes:UP000054977}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 22934 {ECO:0000313|EMBL:SAL37396.1};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; FCNW02000011; SAL37396.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A158GZA6; -.
DR   STRING; 326474.AWB65_02741; -.
DR   OrthoDB; 9761531at2; -.
DR   Proteomes; UP000054977; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR   CDD; cd07731; ComA-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR035681; ComA-like_MBL.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR004797; Competence_ComEC/Rec2.
DR   InterPro; IPR025405; DUF4131.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF13567; DUF4131; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        242..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        285..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        311..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        345..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        428..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        457..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        490..510
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          571..767
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   822 AA;  89193 MW;  EEC5D452B188BCFE CRC64;
     MRGVLLGFAA GVWCLQQQAV LPGWGFFALC ALSCGACGCF RWRRVALIVA AFAFGFAYAA
     LRAEVRLQDQ LPLAYEGRTI EVAGFVRGLP SIDAHGTRFL FEVESNDARL RNFPRIVRLS
     WLVVEGEAPP PELWAGQRWS LGVRLKRAHG NANFGARDAE AALLARNIRA TGYVTRAHRL
     PRDVIGIALA IDRLRAHLRD RIEGVLGDAA HRGIVVALAV GAQDSVSDSD WTLMRATGTS
     HLVAISGLHI GFVAGLAALS IGFAWRRLRW RGTLLPLYVS AQKVAAAGAA AFAAFYAGLA
     GFNVPAQRSL WMLGFVAIAW VTGRRMASSL VLAWALALVL LADPWALTAA GFWLSFCAVA
     AILYAMAAYG RRASKRPDDG EEAFTFEYET QQRAGEALAA ARRGPRPLPF WRRFVYRLRR
     TIASSTRVQY AVTIALAPLT VYWFSQIPLI GPLANAVAIP WVSLLVTPVV LAGVLLPAPL
     DAFAYRLAHH LLTIMCDALT WLAGPAWALW RLPQPGAFAL IAAAVGVAWA LAPRGWPLRF
     AAPLTWLPLL LPAPHAPPPG AFRLTALDIG QGSSIVVETA RHALLFDAGP GPESTHAGER
     IVVPYLFADG LPAIDTLVIS HSDSDHAGGA TAVLQAIDVG QLLASLPPQD ALWQAANERG
     AETLRCAAGQ RWTWDGVEFA ILWPDPKPLE GKPNAQSCVL KVTSAAGRSA LLAADIESDV
     ERTLLKRDAK ALRADVLLVP HHGSKTSSTE PFLDSVEPLV AVFQVGYRNR FHHPHPTVLE
     RYRLRAIELS QSDNDGAVRV DVSSTITLER YRQTHARYWM GR
//