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Database: UniProt
Entry: A0A158J918_9BURK
LinkDB: A0A158J918_9BURK
Original site: A0A158J918_9BURK 
ID   A0A158J918_9BURK        Unreviewed;       438 AA.
AC   A0A158J918;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   31-JUL-2019, entry version 17.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=AWB69_07385 {ECO:0000313|EMBL:SAL65358.1};
OS   Caballeronia udeis.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Caballeronia.
OX   NCBI_TaxID=1232866 {ECO:0000313|EMBL:SAL65358.1, ECO:0000313|Proteomes:UP000054683};
RN   [1] {ECO:0000313|EMBL:SAL65358.1, ECO:0000313|Proteomes:UP000054683}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 27134 {ECO:0000313|EMBL:SAL65358.1};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; FCOK02000076; SAL65358.1; -; Genomic_DNA.
DR   RefSeq; WP_062091558.1; NZ_SNYX01000001.1.
DR   EnsemblBacteria; SAL65358; SAL65358; AWB69_07385.
DR   GeneID; 33103335; -.
DR   OrthoDB; 1464088at2; -.
DR   BioCyc; GCF_001544555:G1EQ2-7303-MONOMER; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000054683; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054683};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
SQ   SEQUENCE   438 AA;  46835 MW;  283D095C8C2705F5 CRC64;
     MEPIKVGLLG FGTVGSGTFT VLRRNQEEIK RRAGRGIEIT RIAVRTPSKV QGAAGIDVTT
     DFNAVVDDPS IDIVAEMIGG TGVARELVLR AIANGKHVVT ANKALLAVHG SEIFEAASKK
     GVMVAFEAAV AGGIPIIKAL REGLTANRIQ YIAGIINGTT NYILSEMRDR GLDFATALKA
     AQELGYAEAD PTFDIEGVDA AHKVTIMSAI AFGVPVQFDR AYVEGISKLD AIDIRYAEDL
     GYRIKLLGIA RRTEKGIELR THPTLIPEKR LLANVEGAMN AVVVHGDAVG TTLYYGKGAG
     AEPTASAVVA DLVDVTRLHT ADPEHRVPHL AFQPDSLANT PILPIEEVTS GYYLRLRVAD
     VTGVLANITR ILADKAISID ALLQKESEHV DGEDKGETDI ILITHVTVEK QVNAAIEQIE
     ALSTVVSKVT KLRMEALN
//
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