ID A0A158K140_9BURK Unreviewed; 1172 AA.
AC A0A158K140;
DT 27-SEP-2017, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Cell division protein FtsK {ECO:0000313|EMBL:SAL74190.1};
GN ORFNames=AWB68_04549 {ECO:0000313|EMBL:SAL74190.1};
OS Caballeronia choica.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Caballeronia.
OX NCBI_TaxID=326476 {ECO:0000313|EMBL:SAL74190.1, ECO:0000313|Proteomes:UP000054770};
RN [1] {ECO:0000313|Proteomes:UP000054770}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Peeters C.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential cell division protein that coordinates cell
CC division and chromosome segregation. The N-terminus is involved in
CC assembly of the cell-division machinery. The C-terminus functions as a
CC DNA motor that moves dsDNA in an ATP-dependent manner towards the dif
CC recombination site, which is located within the replication terminus
CC region. Translocation stops specifically at Xer-dif sites, where FtsK
CC interacts with the Xer recombinase, allowing activation of chromosome
CC unlinking by recombination. FtsK orienting polar sequences (KOPS) guide
CC the direction of DNA translocation. FtsK can remove proteins from DNA
CC as it translocates, but translocation stops specifically at XerCD-dif
CC site, thereby preventing removal of XerC and XerD from dif.
CC {ECO:0000256|ARBA:ARBA00024784}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
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DR EMBL; FCON02000055; SAL74190.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A158K140; -.
DR OrthoDB; 9807790at2; -.
DR Proteomes; UP000054770; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000313|EMBL:SAL74190.1};
KW Cell division {ECO:0000313|EMBL:SAL74190.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 43..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 817..1026
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 132..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..479
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 834..841
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 1172 AA; 122315 MW; B29E897228D349A6 CRC64;
MHTVVLGWFG GSVVWFVPLL WRLAKSMLPG GDGLRGPGTI RLWLGFVGVL VASMALEGAL
LGSFEAAAGV NRCGHALANA LAGLAGRVGG GSIAAAALLV CLPWLCDFQW RSAIGWANVA
FGLGFNPQWF DAREKTPREK PSRKRRARGE PAHRAGGIPG RIAHDAPMLG MPAATSREGG
RYQRPTVWRP PAIQRGDVKR STAAASPSVD VFADRNANAP RNPAPATGRA IPRDLVEPVA
PIGWLGSGSG MRAGSREGAG SSKVANPGTV RPVTAPAASR GFVRTDAPAA APSAAPRTTV
AASAVHAVQP SRSSVKRPAA SMSRPATGSV AAPSAATSRA PVHSRPAEPP GPLPAPDSIQ
ATLRSIEENA ARWTTLAGAG LASGREPQER QPGLQGGSDH SGATRAAGET PKSANAPPIG
DAVRSNAISA AGSSAPSFAL HAITGDVASG AGNAPTEARV APPPVDSERR RDDEAAPEDA
LKSAPAATAL RETEAMPQRV PGQNTPLVSD TTATSLASAT PEGSARSDGT LTGETTGVEA
LQAAAASGAA LTGTAWAMTT PRPAAALEPT QPLSPPAQSP SDTLPWLAAV VRPEAHRPAP
PLPLQIGNTE AENDDTNPAA HQPASNVVRF PGVAIAPTAS PIGEQSAEEP PEATQPGTPR
APIRGFTPTE FEFHAPAASA VELPGFDLLE RASDDIEPVS EERLAETGQL IEQRLQEFKV
PVTVVGASAG PVITRFEVEP ALGVRGSQIV GLMKDLSRGL GLTSIRVVET IPGKTCMGLE
LPNAKRQMIR LSEILEDDVY RNSKSNLTIA MGKDIVGNPV VTDLARAPHM LVAGTTGSGK
SVAVNAMILS LLYKAKPEDV RLIMIDPKML ELSVYEGIPH LLAPVVTDMK LAANALNWCV
GEMEKRYRLM SAVGVRNLQG FNQKVRNADA AGRKLTNPFS LTPDAPEPLS TLPMIVVIID
ELADLMMVAG KQIEQLIARL AQKARAAGIH LILATQRPSV DVITGLIKAN IPTRVAFQVS
SKIDSRTILD QMGAESLLGA GDMLFLPPGT GYPQRVHGAF VADDEVHRVV EYLKQFGEPE
YEEGILSGPA SEGAAQDLFG EAPDAEADPL YDEAVSFVVR TRRASISSVQ RQLRIGYNRA
ARLVEQMETA GLVSPMGNNG NREVLAPPGP AE
//
