ID A0A158NDX0_ATTCE Unreviewed; 1196 AA.
AC A0A158NDX0;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=105618808 {ECO:0000313|EnsemblMetazoa:XP_012055728.1};
OS Atta cephalotes (Leafcutter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=12957 {ECO:0000313|EnsemblMetazoa:XP_012055728.1, ECO:0000313|Proteomes:UP000005205};
RN [1] {ECO:0000313|Proteomes:UP000005205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21347285; DOI=10.1371/journal.pgen.1002007;
RA Suen G., Teiling C., Li L., Holt C., Abouheif E., Bornberg-Bauer E.,
RA Bouffard P., Caldera E.J., Cash E., Cavanaugh A., Denas O., Elhaik E.,
RA Fave M.J., Gadau J., Gibson J.D., Graur D., Grubbs K.J., Hagen D.E.,
RA Harkins T.T., Helmkampf M., Hu H., Johnson B.R., Kim J., Marsh S.E.,
RA Moeller J.A., Munoz-Torres M.C., Murphy M.C., Naughton M.C., Nigam S.,
RA Overson R., Rajakumar R., Reese J.T., Scott J.J., Smith C.R., Tao S.,
RA Tsutsui N.D., Viljakainen L., Wissler L., Yandell M.D., Zimmer F.,
RA Taylor J., Slater S.C., Clifton S.W., Warren W.C., Elsik C.G., Smith C.D.,
RA Weinstock G.M., Gerardo N.M., Currie C.R.;
RT "The genome sequence of the leaf-cutter ant Atta cephalotes reveals
RT insights into its obligate symbiotic lifestyle.";
RL PLoS Genet. 7:e1002007-e1002007(2011).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_012055728.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (APR-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; ADTU01013059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012055728.1; XM_012200338.1.
DR AlphaFoldDB; A0A158NDX0; -.
DR STRING; 12957.A0A158NDX0; -.
DR EnsemblMetazoa; XM_012200338.1; XP_012055728.1; LOC105618808.
DR GeneID; 105618808; -.
DR KEGG; acep:105618808; -.
DR eggNOG; KOG0922; Eukaryota.
DR InParanoid; A0A158NDX0; -.
DR OMA; DPMVAPE; -.
DR OrthoDB; 5488182at2759; -.
DR Proteomes; UP000005205; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd17971; DEXHc_DHX8; 1.
DR CDD; cd21691; GH2-like_DHX8; 1.
DR CDD; cd05684; S1_DHX8_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR044762; DHX8/Prp22_DEXHc.
DR InterPro; IPR049588; DHX8_GH2-like.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049621; S1_DHX8_helicase.
DR InterPro; IPR003029; S1_domain.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF85; ATP-DEPENDENT RNA HELICASE DHX8; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50126; S1; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Reference proteome {ECO:0000313|Proteomes:UP000005205}.
FT DOMAIN 243..314
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 550..713
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 731..911
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 126..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..217
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1196 AA; 136444 MW; B2739580C91CC010 CRC64;
MEEVNQLEHL SLVSKICTEL ENHLGLNDKD LAEFIIHLAE NNKTFLSFKK VLIENGAEFS
DSFIANLLRI IQHMKPVKSS TEKPSKNKQD ELAIKFPALA LPNDDPRSET NDEDIVNDVM
ASLEAFAPSN KKHSANIEKS NGKIDNGEKK NKRERKSRSR SRDKRRHRSL NQKERRRRSR
TRSRSRTRYR SRDRARRRRS GSRERKRSSS RNHKDTRHSR RRDADRSRSR SVEETLSVEP
EVGKIYAGKV ANIVPFGCFV QLEGLRRRWE GLVHISQLRR EGRVANASDV VSRGQKVLVK
VLSVGGQKVS LSMKDVDQET GRDLNPVVPI AKADEDEKHL RNPDRPTSLL ELQGNYDEDE
TYSRKRVQRL SSPEKWEIKQ MLAASCIDRS ELPEFDTETG ILPREDDEEE DVEIELVEEE
PPFLHGHGRA LGDLSPVRIV KNPDGSLAQA AMMQSALAKE RREQKMLQRE QEMDSVPTGL
NKNWIDPLPE AESRTLAANM RGIGLQTQDL PEWKKHVIGG KKSSFGKKTN LTLLEQRQSL
PIYKLRDDLV KAVTDNQILI VIGETGSGKT TQITQYLAET GFTARGKIGC TQPRRVATMS
VAKRVAEEFG CCLGQEVGYT IRFEDCTGPE TSIKYMTDGM LLRECLMDLD LKTYSVIMLD
EAHERTIHTD VLFGLLKQAV GRRPDLKLIV TSATLDAVKF SQYFFEAPIF TIPGRTFEVE
VMYTKEPETD YLDAALITVM QIHLREPPGD ILLFLTGQEE IDTACEILYE RMKSLGPDVP
ELIILPVYSA LPSEMQTRIF EPAPPGSRKV VIATNIAETS LTIDGIYYVV DPGFVKQKVY
NSKTGMDSLI VTPISQAAAK QRSGRAGRTG PGKCYRLYTE RAYRDEMLPT PVPEIQRTNL
ATTVLQLKTM GINDLLHFDF MDAPPVESLI MALESLHSLS ALDNEGLLTR LGRRMAEFPL
EPNLSKMLIM SVHLQCSDEI LTIVSMLSVQ NVFYRPKDKQ ALADQKKAKF NQPEGDHLTL
LAVYNSWKNN KLSNAWCYEN FVQIRTLKRA QDVRKQLLGI MDRHKLDVVS AGKNTVRIQK
AVCSGFFRNA AKKDPQEGYR TLVDSQVVYI HPSSALFNRQ PEWVIYHELV QTTKEYMREV
TTIDPKWLVE FAPAFFKFSD PTKLSKFKKN QRLEPLYNKY EEPNAWRISR VRRRRN
//
