ID A0A158NGD7_ATTCE Unreviewed; 792 AA.
AC A0A158NGD7;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Major facilitator superfamily associated domain-containing protein {ECO:0000259|Pfam:PF12832};
GN Name=105619686 {ECO:0000313|EnsemblMetazoa:XP_012056595.1};
OS Atta cephalotes (Leafcutter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=12957 {ECO:0000313|EnsemblMetazoa:XP_012056595.1, ECO:0000313|Proteomes:UP000005205};
RN [1] {ECO:0000313|Proteomes:UP000005205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21347285; DOI=10.1371/journal.pgen.1002007;
RA Suen G., Teiling C., Li L., Holt C., Abouheif E., Bornberg-Bauer E.,
RA Bouffard P., Caldera E.J., Cash E., Cavanaugh A., Denas O., Elhaik E.,
RA Fave M.J., Gadau J., Gibson J.D., Graur D., Grubbs K.J., Hagen D.E.,
RA Harkins T.T., Helmkampf M., Hu H., Johnson B.R., Kim J., Marsh S.E.,
RA Moeller J.A., Munoz-Torres M.C., Murphy M.C., Naughton M.C., Nigam S.,
RA Overson R., Rajakumar R., Reese J.T., Scott J.J., Smith C.R., Tao S.,
RA Tsutsui N.D., Viljakainen L., Wissler L., Yandell M.D., Zimmer F.,
RA Taylor J., Slater S.C., Clifton S.W., Warren W.C., Elsik C.G., Smith C.D.,
RA Weinstock G.M., Gerardo N.M., Currie C.R.;
RT "The genome sequence of the leaf-cutter ant Atta cephalotes reveals
RT insights into its obligate symbiotic lifestyle.";
RL PLoS Genet. 7:e1002007-e1002007(2011).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_012056595.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (APR-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC {ECO:0000256|ARBA:ARBA00005241}.
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DR EMBL; ADTU01014832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012056595.1; XM_012201205.1.
DR AlphaFoldDB; A0A158NGD7; -.
DR EnsemblMetazoa; XM_012201205.1; XP_012056595.1; LOC105619686.
DR GeneID; 105619686; -.
DR KEGG; acep:105619686; -.
DR eggNOG; KOG3762; Eukaryota.
DR InParanoid; A0A158NGD7; -.
DR OrthoDB; 2905618at2759; -.
DR Proteomes; UP000005205; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd17335; MFS_MFSD6; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 3.
DR InterPro; IPR024989; MFS_assoc_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR16172:SF35; MFS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR16172; UNCHARACTERIZED; 1.
DR Pfam; PF12832; MFS_1_like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005205};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 515..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..671
FT /note="Major facilitator superfamily associated"
FT /evidence="ECO:0000259|Pfam:PF12832"
FT REGION 709..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..727
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..760
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 792 AA; 89218 MW; DF2169D8D6E4177C CRC64;
MITTKIFFSR IIKDFKSKEL MPLKLIFFVQ ASTLYVLYPY LTIHMRELGI NVEETAIMSS
ITPLVAMVMP PLAGMLADRI GNFRILLSLF SAFGGLAALL LLLVPIGRVT VHFPQRIIMD
LGCEGRNGSL LHTMSQIHPC ETKLESEEIA VNVESCGFVC HVETNNETDG SQILKSRLYT
IRHLNFQTGV NTSYKYIVTP SDLATSIQQE DMKEHRQLKN NEFFKTSIRQ VSKTHYFFPT
DQLFSFSCMS LSGHIQDIDN FTTDTFKMSR NHTSCVFDNL MKSKDNINRT INYHLYKSKI
KSLKPDEDDL QEEQQRYLSE KISWAGEDFQ KPICDDLESN INNQITIQVR LYDHEAKLEV
TNRVLNINEC RKKCIVTLPR NALCSNMNME VEYNIKLTFW LYLVIRVFIG IIGGTTFAMF
EGAVIAILRE QEADYGLQRI YGSIGGMISS PLSGLLIDYA SKGKGYTDFR PAFYLYAALK
LASGILMLLI NLEFKAPAKN VVRDVFTVLR NIETAVLFLA CFVLGTAWGY IESFLFWLIQ
DLGGSRSLMG ITVAVGGIAG IPLLALSGPI ISKIGHANVL FIGFVFYAIR LCGYSLIYDP
WLTLIFEALE SVTTSLSFTA AVTYAAKLST TSTDSSIQGL LGGVYYGVGK GSGSLIGGYL
MKFFGTRPTY QIFAVVTLLT GIIYFIFNVT YLKKRSQLEG NDIVKKKSKN IDEQDSPKKH
TNDISLDEKS QNHNQINNKS KMMGNDNKGF LKEESHNNKK TNELNSTEIE AIRNAKNIDE
LNEIQLENIR TN
//
