ID A0A158NKC7_ATTCE Unreviewed; 685 AA.
AC A0A158NKC7;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Acyl-CoA synthetase short-chain family member 3, mitochondrial {ECO:0000256|ARBA:ARBA00040004};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
DE AltName: Full=Acetate--CoA ligase 3 {ECO:0000256|ARBA:ARBA00042755};
GN Name=105621125 {ECO:0000313|EnsemblMetazoa:XP_012057985.1};
OS Atta cephalotes (Leafcutter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=12957 {ECO:0000313|EnsemblMetazoa:XP_012057985.1, ECO:0000313|Proteomes:UP000005205};
RN [1] {ECO:0000313|Proteomes:UP000005205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21347285; DOI=10.1371/journal.pgen.1002007;
RA Suen G., Teiling C., Li L., Holt C., Abouheif E., Bornberg-Bauer E.,
RA Bouffard P., Caldera E.J., Cash E., Cavanaugh A., Denas O., Elhaik E.,
RA Fave M.J., Gadau J., Gibson J.D., Graur D., Grubbs K.J., Hagen D.E.,
RA Harkins T.T., Helmkampf M., Hu H., Johnson B.R., Kim J., Marsh S.E.,
RA Moeller J.A., Munoz-Torres M.C., Murphy M.C., Naughton M.C., Nigam S.,
RA Overson R., Rajakumar R., Reese J.T., Scott J.J., Smith C.R., Tao S.,
RA Tsutsui N.D., Viljakainen L., Wissler L., Yandell M.D., Zimmer F.,
RA Taylor J., Slater S.C., Clifton S.W., Warren W.C., Elsik C.G., Smith C.D.,
RA Weinstock G.M., Gerardo N.M., Currie C.R.;
RT "The genome sequence of the leaf-cutter ant Atta cephalotes reveals
RT insights into its obligate symbiotic lifestyle.";
RL PLoS Genet. 7:e1002007-e1002007(2011).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_012057985.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (APR-2016) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate;
CC Xref=Rhea:RHEA:46172, ChEBI:CHEBI:17968, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371,
CC ChEBI:CHEBI:456215; Evidence={ECO:0000256|ARBA:ARBA00036650};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46173;
CC Evidence={ECO:0000256|ARBA:ARBA00036650};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; ADTU01018779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADTU01018780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012057985.1; XM_012202595.1.
DR AlphaFoldDB; A0A158NKC7; -.
DR STRING; 12957.A0A158NKC7; -.
DR EnsemblMetazoa; XM_012202595.1; XP_012057985.1; LOC105621125.
DR GeneID; 105621125; -.
DR KEGG; acep:105621125; -.
DR eggNOG; KOG1175; Eukaryota.
DR InParanoid; A0A158NKC7; -.
DR OrthoDB; 144557at2759; -.
DR Proteomes; UP000005205; Unassembled WGS sequence.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005205}.
FT DOMAIN 52..106
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 113..495
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 560..638
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 685 AA; 76721 MW; C6EC566E93E11486 CRC64;
MLHRMKPDFL DAESESSRKT CLESCIVRPR ISRKGDSNDY IMNPHCNDCP TYEEAYRKSL
ESPEEFWGEI AGCLDWNKPW HKVLDNSNEP FTKWFIGGEL NACYNAVDRH VHAGYGEKTA
LIHDSPQTSS IRKVTYNELL EKTSVLAGAL ADLGIRKGDR VIIYMPLIPE TIIAILATAR
LGAIHSVVFG GFAANELASR IDHAKSKVII AASCGLEPSK VIKYTTMLNN ALDMIIVPKP
KCIVFQRRNV WEAPLFESQF DWDDIMKRSK PHPCVMVEAN DPLYILYTSG TTGEPKGILR
PIGGHLVSLC WSMQTIYGLN KNSIWWVASD MGWVVGHSYI CYGPLVKGAT SIMYEGKPDR
TPDAGQYFRL IEQHSINGIF CVPTALRVIK RADPETLLGK KYSLKSLKTI FVAGEFCDYE
TKAWAEKTFK VPILNHWWQS ETGHPITALC LGYGHYANLP KFSTGLPIPG YEIHVLREDG
SKAPQHELGR IAIKLPLPPG FMLTLYQASE RFKQVYFSTF PGYYDTMDAG YIDEFGYVYV
TARDDDIINV AGHRISTSAL EDIILGHANV VDAAVIGVPD HMKGEVPLCL YVRREDATSN
EEEINQELIA RVRKMLGPIA SFRTVAAITA LPRTRSGKII RKAIATLARS KQVKISSTIE
DPTVFREIKK VLQKLGYAKL APDPQ
//
