ID A0A158NMQ5_ATTCE Unreviewed; 1607 AA.
AC A0A158NMQ5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=105621992 {ECO:0000313|EnsemblMetazoa:XP_012058813.1};
OS Atta cephalotes (Leafcutter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=12957 {ECO:0000313|EnsemblMetazoa:XP_012058813.1, ECO:0000313|Proteomes:UP000005205};
RN [1] {ECO:0000313|Proteomes:UP000005205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21347285; DOI=10.1371/journal.pgen.1002007;
RA Suen G., Teiling C., Li L., Holt C., Abouheif E., Bornberg-Bauer E.,
RA Bouffard P., Caldera E.J., Cash E., Cavanaugh A., Denas O., Elhaik E.,
RA Fave M.J., Gadau J., Gibson J.D., Graur D., Grubbs K.J., Hagen D.E.,
RA Harkins T.T., Helmkampf M., Hu H., Johnson B.R., Kim J., Marsh S.E.,
RA Moeller J.A., Munoz-Torres M.C., Murphy M.C., Naughton M.C., Nigam S.,
RA Overson R., Rajakumar R., Reese J.T., Scott J.J., Smith C.R., Tao S.,
RA Tsutsui N.D., Viljakainen L., Wissler L., Yandell M.D., Zimmer F.,
RA Taylor J., Slater S.C., Clifton S.W., Warren W.C., Elsik C.G., Smith C.D.,
RA Weinstock G.M., Gerardo N.M., Currie C.R.;
RT "The genome sequence of the leaf-cutter ant Atta cephalotes reveals
RT insights into its obligate symbiotic lifestyle.";
RL PLoS Genet. 7:e1002007-e1002007(2011).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_012058813.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (APR-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ADTU01020670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012058813.1; XM_012203423.1.
DR STRING; 12957.A0A158NMQ5; -.
DR EnsemblMetazoa; XM_012203423.1; XP_012058813.1; LOC105621992.
DR GeneID; 105621992; -.
DR KEGG; acep:105621992; -.
DR eggNOG; KOG0619; Eukaryota.
DR InParanoid; A0A158NMQ5; -.
DR OrthoDB; 2900279at2759; -.
DR Proteomes; UP000005205; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45930; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR PANTHER; PTHR45930:SF4; G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00365; LRR_SD22; 3.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005205};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1607
FT /note="G-protein coupled receptors family 2 profile 2
FT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007629347"
FT TRANSMEM 745..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 780..799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 811..830
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 860..880
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 900..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1016..1039
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 242..350
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 335..425
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 742..1040
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 948..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1182..1216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..975
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1607 AA; 180764 MW; 3E03347F245B83B4 CRC64;
MKVSLLFAIL LPTWANAIVC PQHCLCKSVG AQAEWLRLKC SDGLEEIKDI DVNKVNVELI
QLDLSKNVIY VVEVDAFKNL TNLRRLDLSK NKIISIGEGC FNGLANLERL DLSQNQISII
DSYAFKKLLN LKRLDLSGNK ITALAPSLFH DLLALERLKL NGNSLTTLKE GTFHGLNILK
QLDLSNNLWK CDCDLYWFSN WIYNSSIKLN LTPKCSSPAF AKGQSLKKLK FWDELQCQWM
SPAIEIRPIQ NQVVFAGDSI TLKCRAPSVT VDKSARLNWL WYPNASAEIV DLNSYRDPRN
LPNIKVDNRY LPDSGIVDSA LSIIPIKEEH NGQWNCLLVS VNGNKSKAVS VIVISEHTRY
CPLAVTKNNK GIYTWPKTIV GWKAELPCEV DRLSGLMQAP LKAFYHCNTS GQWERLNTES
CPYISHTTKI LEQFSKVNLS LTKSSLLETA KRFKNYTGNG SVKLTDPVEI HFIVRTIENY
LNFLIDEKEL GIMLVDIVSS MMKLPKEMLK RAEINFKACT RLIKAIEHIT EFTPSIQSHK
KYMALEEFRV KRDSFGGLTC TWYTNIAANA DSDTRFLHCT TINRTTPINT KDKAIEASIQ
LPASLLQHSQ DSAIAQQLMI YMYSDSRFFP KTIANDSMDI STCIAGSKLI GTSVRNLSEP
VYIMLKAPLY HYNGKRPRPV VWDETLNNVG GWTSDGCHLI NLLSNSLIVF HCDRLGYYGL
LQDISYFDMD GNNLHGAKFR YSHPAIYIGS FVTITCLMIT SVTYIISYTS ITMPKKAKHS
IINTWFAMAL LSFLYSIGIQ QTEHIEICQG VGLTLHYLSL CCLLWMAVSA SNMHKKLTKP
GLNVIPDDEL PDQPLPKPLL GLYLVGWGVA LIICGISGAI NLREYAGYSH CFLTSGPALA
ALFIPCGILI AYLLIFLLLI RRAIQNVDMN TQLSEGTQAT ENMDLELLEP NANPSGDRNS
MRSTQTVSSD IEDPEHSQFT QWKGQVIMLV LYLISWSSAA AVTIKPFDSM PFEETVFAVI
YAITTSSLGI FVLFFYGIAR NDVRSQWLKM RCWLEKRKNR CCRTRSVCDA NSVIPTQPLV
QNFVPPLSNS QATQAISDTN SVSSSRNTNQ SQQLYNSSKL ADLANRENVS AVNTKAANLI
VMHRHQYHSN NSVTTYTEPS SACVEMFYNP HQSGVARKFF KKQRRHATAK KNNLGPRKQG
DGGATSDGGS CVSIPRPTAK INNSLERSIL SSSAKVNNTN IHVELNPIND IKNVNILSDS
GGSISEERIP MRFVIGQENL MHSIKKINNS VQQDNPHVNV MMSNTREMLQ PRRMAQDSDA
DVSKTDEEWH LRNVSQQCSL EYSSEMDTVT QMTSERSDHN LSEIYENVEV VQHERFSRKR
CPSVNEMEIT AEERISRDVG RLYLSNSMYC LPLEYEKPLI NNYCNSLNDV TSLTSAKYRG
YSKPSFIDIQ STTSSNLCGQ QVPESQESFD RSERSLFEIN SLTSDNPCTL TPHAETPYAC
SLSNVYYISD KSLEENNSHE KSQLPDVDHN VFNAPESKNF LLEKNFSSLA DIPSISRSSS
RDINNLNLID EMNAFANPAG DIQQFEADEI YLDESVNHLP VKKETSV
//
