ID A0A158NN36_ATTCE Unreviewed; 1329 AA.
AC A0A158NN36;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000256|ARBA:ARBA00019541};
GN Name=105622120 {ECO:0000313|EnsemblMetazoa:XP_012058944.1};
OS Atta cephalotes (Leafcutter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=12957 {ECO:0000313|EnsemblMetazoa:XP_012058944.1, ECO:0000313|Proteomes:UP000005205};
RN [1] {ECO:0000313|Proteomes:UP000005205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21347285; DOI=10.1371/journal.pgen.1002007;
RA Suen G., Teiling C., Li L., Holt C., Abouheif E., Bornberg-Bauer E.,
RA Bouffard P., Caldera E.J., Cash E., Cavanaugh A., Denas O., Elhaik E.,
RA Fave M.J., Gadau J., Gibson J.D., Graur D., Grubbs K.J., Hagen D.E.,
RA Harkins T.T., Helmkampf M., Hu H., Johnson B.R., Kim J., Marsh S.E.,
RA Moeller J.A., Munoz-Torres M.C., Murphy M.C., Naughton M.C., Nigam S.,
RA Overson R., Rajakumar R., Reese J.T., Scott J.J., Smith C.R., Tao S.,
RA Tsutsui N.D., Viljakainen L., Wissler L., Yandell M.D., Zimmer F.,
RA Taylor J., Slater S.C., Clifton S.W., Warren W.C., Elsik C.G., Smith C.D.,
RA Weinstock G.M., Gerardo N.M., Currie C.R.;
RT "The genome sequence of the leaf-cutter ant Atta cephalotes reveals
RT insights into its obligate symbiotic lifestyle.";
RL PLoS Genet. 7:e1002007-e1002007(2011).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_012058944.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (APR-2016) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004557}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004557}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WD repeat SCAP family.
CC {ECO:0000256|ARBA:ARBA00007410}.
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DR EMBL; ADTU01020975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012058944.1; XM_012203554.1.
DR STRING; 12957.A0A158NN36; -.
DR EnsemblMetazoa; XM_012203554.1; XP_012058944.1; LOC105622120.
DR GeneID; 105622120; -.
DR KEGG; acep:105622120; -.
DR eggNOG; KOG1933; Eukaryota.
DR InParanoid; A0A158NN36; -.
DR OMA; IMKQYNV; -.
DR OrthoDB; 2875749at2759; -.
DR Proteomes; UP000005205; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032934; F:sterol binding; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032933; P:SREBP signaling pathway; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR030225; SCAP.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46378; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR46378:SF1; STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50156; SSD; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005205};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT TRANSMEM 12..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 271..429
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REPEAT 768..807
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 817..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1329 AA; 149537 MW; B9965116DBE9F442 CRC64;
MSRSLPDRVA GLYYAHGLFC SSHPVIVLSL AISVLLLCCC PLVNLPMPGN APKILINDTV
LPVINDTETS VLYVQQVVLR IGVMPWSEDL TLMDAFRGPL YEVFNLLEII QNYQHPETLK
TLGQVCLHIE AVKKRNGKKA EVLPEYNCLV LSPANLWQQS IELFSQDTNL INTIFSYQNL
QRGKISLAEV MFGMSLKETG VKRYPARVRQ RILQYAVTIY LKKYDQEFIK GLQHRLRTYY
QLHQTVDNST DVDTHNEVLN IFYPGEFNYS EFFPLMMTSL ALFFYEYFQV RKIELVKSKI
GIAFSASVTV MGSLSMTVGV CFFFGLTLSM SAKEVFPYLV IIFGLENIQV LTKSVVSTPA
QLDVKIRVAQ ALSKEGWSIT KNLLTEVTIL TIGLFTFVPA IQEFCIFAIV GLLNDFFLQM
VFFSTILAID IRRTELSSEN SKFHLSHIQT SRRQQFTTTI TNRKPHIFRS KSHPRLNGLS
TGPTNVIAPN TQNTHTLTKI PKRLRLVYLW ARTRIFQRAF MVGMVVWISM AINNSGIIEH
IIHLSETLKP ETDMDGYTVD KPPSLNDYVK LNTVTPISIS PATVAPNKLN EQNLTNNTTE
ELNKLRPMDF PPWNSLSLYH WSSILSMYNV SIAGGRVTIL PTIKLSYAVS PQLAKQISNP
NDVQHFQWQS LATAALDPLD FSDMEVPSRS EGRVFNTDTP FVPSSPMEIF LAALLCLISV
IVVAYTMVVL YRCICTRNYA EWRASWHQQE KTHDYVTQLV LEAVPLVLEG HTQEVECIAT
DGNTVASTCL AGHIRIWDST SGEQLAHIDR RQFFSGPQKT LSQASPDADE LMSDYESGSP
PSRGEMEVAQ SMGLYSPASA MCQGKLSPAY NMRRVNSNNN NDHKRRSIGN MLDYDYQLNE
LNSDNKQKLL RRSLGSAYDL PDLKPAINIK FSTIKYTPSQ KNYDQGYDFG ERYKILFDEH
NKSIEEMQKS KIREQLGVFP ARSNNLVGST SSINTDRTIQ SSPIIAAIWC MDYQENLVVV
GCANGSLEFW EGTTGRFKCL FDDGSGLGIS AVRLVGSRVV AAKLNGVVDF LQLESYSEGQ
QIDWGFTSYR RTHVRTGSAG SPMDLNNYMQ TEEDLRCMKI GSHRAHQQAI TVLDSEGGRV
LTGSQDHTLK VYRLEDQLPL YTLHGHCGPI SCLFIDRISP MTSGSGSQDG LLCVWDLLTG
ACMYSIQAHD GAVAAITCSV SYVISIGTDE RLCVWERFQG HLLHTLPAHK AAYSLQLVML
THHLLITSNQ GSLVVWDVRT GEPVREVRLG HKDSCIFVKQ MLALRDSVVC DYGRQLRIVR
FPLVSDKLD
//
