ID A0A158NSK1_ATTCE Unreviewed; 1122 AA.
AC A0A158NSK1;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN Name=105623738 {ECO:0000313|EnsemblMetazoa:XP_012060509.1};
OS Atta cephalotes (Leafcutter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Atta.
OX NCBI_TaxID=12957 {ECO:0000313|EnsemblMetazoa:XP_012060509.1, ECO:0000313|Proteomes:UP000005205};
RN [1] {ECO:0000313|Proteomes:UP000005205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21347285; DOI=10.1371/journal.pgen.1002007;
RA Suen G., Teiling C., Li L., Holt C., Abouheif E., Bornberg-Bauer E.,
RA Bouffard P., Caldera E.J., Cash E., Cavanaugh A., Denas O., Elhaik E.,
RA Fave M.J., Gadau J., Gibson J.D., Graur D., Grubbs K.J., Hagen D.E.,
RA Harkins T.T., Helmkampf M., Hu H., Johnson B.R., Kim J., Marsh S.E.,
RA Moeller J.A., Munoz-Torres M.C., Murphy M.C., Naughton M.C., Nigam S.,
RA Overson R., Rajakumar R., Reese J.T., Scott J.J., Smith C.R., Tao S.,
RA Tsutsui N.D., Viljakainen L., Wissler L., Yandell M.D., Zimmer F.,
RA Taylor J., Slater S.C., Clifton S.W., Warren W.C., Elsik C.G., Smith C.D.,
RA Weinstock G.M., Gerardo N.M., Currie C.R.;
RT "The genome sequence of the leaf-cutter ant Atta cephalotes reveals
RT insights into its obligate symbiotic lifestyle.";
RL PLoS Genet. 7:e1002007-e1002007(2011).
RN [2] {ECO:0000313|EnsemblMetazoa:XP_012060509.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (APR-2016) to UniProtKB.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; ADTU01024983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012060509.1; XM_012205119.1.
DR AlphaFoldDB; A0A158NSK1; -.
DR STRING; 12957.A0A158NSK1; -.
DR EnsemblMetazoa; XM_012205119.1; XP_012060509.1; LOC105623738.
DR GeneID; 105623738; -.
DR KEGG; acep:105623738; -.
DR eggNOG; KOG0217; Eukaryota.
DR InParanoid; A0A158NSK1; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000005205; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000005205}.
FT DOMAIN 979..995
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 19..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..116
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1122 AA; 127694 MW; 5E040DB965C2BE17 CRC64;
MPKVNTILNY FTSPKTIKKL ETTKEERDKS QTPKRDLKNK GFIKNGKENQ NTDDKKRSHN
KDTEKEEDES IKPKRRRLII PDIDSDEDSG DEFKPGSESE ESESVSEGDT EQEPSTEEET
PEKKRKTSSV KFKLKQASFR NTKANKKDLK QPSQPVQSQI ISNGLSAAHT WPHLKLDFLH
PEKIRDIHRR MLNDPDYDPK TLYVPTEFLI NQTPAMRQWW ELKSKHFDCV FFFKIGKFYE
LYHMDAVIGV NELSLTYMRG EFAHSGFPEI GYGRYSASLI ERGYKVARVE QTENPEMMAA
RCSKMTKPTK FDKVVKREIC QVSTRGTRVY TPLDVETSTP NSNYLLSLVE KCDLSSTISS
FGVCFIDTTI GEFYLGQFVD DRCNSRLLTL LAHHPPIHVI YERSNLSQKT LQLINNTLPT
ALKESLQREA QFWSATTVLK KLHEGSYFKK EDSNFAWPEG LKPYLDEGDS LGLTPADNKE
LAVHALGGCV CLLKEFLLEQ QLLAQGCFNT YIPPDFSIAN SRTGLNYANT MVIDAVTIKN
LRLFGEGSLI NVLDHCCTAF GKRLLREWVC RPSCRKIVII ERQEAVQELL DRMDVMQSAR
IILSTLPDLE RLLSKIHAQG NAAKMKNHPE GRAIMFEGPT YSKRVIVDFT TTLAKFEEVL
KFIELFEDFK SNLITRYTKY EPNGDFPRLR ETLDYFKTAF NHEEAKKQGY IVPKKGVDAE
YDSVLTELAD IKKDLDKYLE KQKQHFGVKV TFHGTDRKRY QIEIPESQVK KVDPGYELQS
QRKGFKRYYT AEAKELLTRQ MNAEEHKDKV LKDLNRRIFA QFSEKYDMWH AAVYKLATMD
VLISLADYAR NGDDMCIPEI HDGSDGEIFI KIKDGQHPCI VSDNFIPNDT LLATDGTASF
MILTGPNMGG KSTLMRQMGL ITIMAQIGSY VPASSCCMTL VDRIFTRLGA NDDILAGQST
FLVELSETAT ILQHATPYSL VLLDELGRGT STYDGTAIAA AVVDALTKLK CRTLFSTHYH
SLVEDYKTNE EVTLAHMACM VETEEEEEVS QETVTFLYKL SEGACPKSYG FNAARLAGVP
SVITKRAHEI ASRMEQETNH KHIFNALCKA NGVRMRSLIA TI
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